Table 2. Best fit parameters of all models.

Models presented in main figures
	Single-sensor model (Figure 4)	Dual fusion-sensor model, cooperativity 2 (Figure 6)	Unpriming model, cooperativity 5 (Figure 7)
Qmax	8.42 fC	4.51 fC	13.77 fC
krep	165.53 s−1	159.30 s−1	134.85 s−1
nsites	216	211	180
k2		4.10e7 M−1s−1
s		510.26
u			236.82 s−1
kM,prim			55.21 nM−1
Cost value (see Materials and methods)	9.689	4.129	0.340
Models presented in figure supplements
	Dual fusion-sensor model, cooperativity 5 (Figure 6—figure supplement 1)	Unpriming model, cooperativity 2 (Figure 7—figure supplement 1)	Site activation model (Figure 7—figure supplement 3)
Qmax	8.10 fC	13.49 fC	12.59 fC
krep	492.56 s−1	106.59 s−1	141.20 s−1
nsites	112	203	189
k2	5.41e6 M−1s−1
s	261.07
u		5207.70 s−1
kM,prim		7.61 nM−1
β			0.09 s−1
γ			194.77 s−1
δ			10.70 s−1
Cost value (see Materials and methods)	2.941	0.642	1.57