Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins

Nucleic Acids Research, 2019, 47(13): 7130–7142, https://doi.org/10.1093/nar/gkz551

The Authors wish to correct an error in Figure 5, panel D.

Figure 5.

Plot (A) (2’OMeRNA) and plot (B) (HNA) showing the overlay between the ‘open’ WT-dsXNA (gray) and closed 189insG–dsXNA complexes (green with orange insert). Position of the latch domain is indicated by an arrow. The evolutionary conserved clamp-closing in green complexes is highlighted in a dashed circle. RMSF plots in panel (C) (2’OMeRNA) and panel (D) (HNA), different domains are depicted below the graph. Red asterisk indicates the insert position.

The RMSF plots in panel D are for HNA not 2’OMeRNA. The colour legend of panel D should be:

• ChVlig – dsDNA (orange)

• ChVling – dsHNA (black)

• 189insG – dsHNA (green)

The figure caption is correct. A new Figure 5 is provided below and the published article has been corrected.