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. 2020 Mar 31;104(4):744–753. doi: 10.1097/TP.0000000000003060

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 3. — Renal prednisolone accumulation after LP treatment. A, Prednisolone concentration in the allograft and contralateral kidney was determined using HPLC. At d 7 post-Tx, prednisolone was detected in higher quantities in allografts of mice treated with LP, but not in allografts of mice treated with P alone. The contralateral native kidney of the recipient treated with LP contained also lower levels of prednisolone. Data points represent individual mice. * P < 0.05, unpaired Students t-test, N = 4 per group. B, Messenger RNA expression of the glucocorticoid responsive gene Fkbp5 in the allografts is plotted as copies per actin. Expression is upregulated in LP-treated allografts, compared with P and NA treated (mean ± SD. **P < 0.01, one-way analysis of variance with a Tukey multiple comparisons test. NA = no additional treatment; N = 8, P = prednisolone; N = 10, LP = liposomal prednisolone; N = 8. HPLC, high performance liquid chromatography.