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. 2020 Mar 31;104(4):744–753. doi: 10.1097/TP.0000000000003060

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 4. — CD45 and proinflammatory cytokine expression after LP treatment. A, First, proinflammatory cytokine mRNA expression in allografts vs contralateral kidneys after NA treatment was investigated and showed significant upregulation of Ccl2 and TNF-α, expression in the allografts at d 7. The other investigated cytokines IL-6, CXCL2, IL1-β, and IL10 did not differ compared with the healthy control kidney. B, Cd45 messenger RNA expression in the allograft was significantly reduced by LP treatment compared with NA or P. Surprisingly, the expression of Ccl2 and TNF-a was similar in the allografts (mean ± SD. One-way analysis of variance with a Tukey multiple comparisons test. NA = no additional treatment; N = 8, P = prednisolone; N = 10, LP = liposomal prednisolone; N = 8). IL, interleukin; TNF, tumor necrosis factor.