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. 2010 May 21;1:150–165. doi: 10.1007/978-0-387-72430-0_15

Tissue Culture Models

Roger A Vertrees 10, Thomas Goodwin 11, Jeffrey M Jordan 12, Joseph B Zwischenberger 10
Editors: Dani S Zander3, Helmut H Popper4, Jaishree Jagirdar5, Abida K Haque6,7, Philip T Cagle8,9, Roberto Barrios8,9
PMCID: PMC7147448

Abstract

The use of tissue cultures as a research tool to investigate the pathophysiologic bases of diseases has become essential in the current age of molecular biomedical research. Although it will always be necessary to translate and validate the observations seen in vitro to the patient or animal, the ability to investigate the role(s) of individual variables free from confounders is paramount toward increasing our understanding of the physiology of the lung and the role of its cellular components in disease. Additionally, it is not feasible to conduct certain research in humans because of ethical constraints, yet investigators may still be interested in the physiologic response in human tissues; in vitro characterization of human tissue is an acceptable choice.

Keywords: Airway Smooth Muscle, Lung Cancer Cell Line, Small Cell Lung Carcinoma, Airway Smooth Muscle Cell, Severe Acute Respiratory Syndrome

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