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. 2020 Mar 15;12(3):268. doi: 10.3390/pharmaceutics12030268

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Dixon plot for the inhibitory effect of (A) DWP16001, (B) dapagliflozin, and (C) ipragliflozin on the uptake of [¹⁴C]methyl-a-D-glucopyranoside (AMG) in CHO-SGLT2 cells. Each symbol represents the concentration of [¹⁴C]AMG: ●, 1 μM; ○, 2.5 μM; ▼, 5 μM; △, 50 μM. Replot of the slopes of Dixon plot (slopes vs 1/[S]) was shown for (D) DWP16001, (E) dapagliflozin, and (F) ipragliflozin. V indicates the SGLT2-mediated uptake rate of [¹⁴C]AMG and S indicates the concentration of [¹⁴C]AMG. The data are the means±standard deviations of triplicate measurements.