To the Editor: We read with great interest the Commentary by Lebwohl et al1 recently published in the Journal of the American Academy of Dermatology. The authors provided a pertinent overview of infection risk associated with commonly used biologics to treat psoriasis in light of the current coronavirus disease 2019 (COVID-19) outbreak. We agree that this time has been particularly concerning for patients taking immunomodulators/immunosuppressants who are unsure of their risk for severe disease.
In response to the previous commentary, the goal of this letter is to expand and provide the latest information about COVID-19 along with considerations for addressing patient concerns surrounding dermatology-related immunomodulator/immunosuppressant use.
Theoretical data from previous coronavirus outbreaks has suggested a strong role for type I interferon, B-cell–released antibodies, tumor necrosis factor-α, and other cytokines in the viral immune response (Fig 1 ).2, 3, 4 Interleukin (IL) 17 cytokines are important for immune cell recruitment to infection sites to promote clearance, while also activating downstream cascades of cytokines and chemokines.4 IL-1 promotes fever and the differentiation of T-helper cells to IL-17–producing T cells. Tumor necrosis factor-α promotes dendritic cell differentiation, leukocyte recruitment, and mediates fever.4 Antibodies produced by plasma cells help to neutralize the virus, limit infection, and prevent future infections. Disruption of B-cell differentiation into plasma cells could limit antibody production.3
Broad immunosuppression across multiple cytokine axes with immunosuppressants has the potential to increase susceptibility, persistence, and reactivation of viral infections. Immunosuppressants decrease cytokines that recruit and differentiate immune cells needed to clear the infection. In addition, inflammatory mediators can become hyperactivated, resulting in a “cytokine storm,” which is the primary cause of death in severe disease.3
Whether withdrawal of broadly immunosuppressive therapies may increase the risk of precipitating cytokine storm is unknown. Therefore, classic immunosuppressants may present the most concerning risk for those affected by COVID-19 (Table I ). Immunomodulators, such as biologics, that do not target vital domains within the viral immune response may dampen, but not significantly affect viral clearance.
Table I.
Drug class | Mechanism of action | Drug name | Risk | Comments/considerations∗ |
---|---|---|---|---|
Classic immunosuppressants | ||||
Inhibits NF-κB | Corticosteroids | Likely concerning risk | Consider stopping when viral symptoms present especially with known or potential exposure | |
Calcineurin inhibitor | Tacrolimus | |||
Cyclosporine | ||||
Antimetabolites | Inhibits DNA replication | Mycophenolate mofetil | ||
Azathioprine | ||||
Methotrexate | ||||
Immunomodulators | ||||
Monoclonal antibodies | TNF-α inhibition | Infliximab | Likely moderate risk | Continue if viral symptoms are mild, consider stopping if viral symptoms worsen or high fever develops |
Receptor fusion protein | Etanercept | |||
Monoclonal antibodies | Certolizumab | |||
Monoclonal antibodies | Adalimumab | |||
IL receptor modulators | IL inhibition | Anakinra (IL-1) | ||
Monoclonal antibodies | Dupilumab (IL-4) | Likely low risk | Continue unless severe symptoms present | |
Monoclonal antibodies | Brodalumab (IL-17) | Likely moderate risk | Continue if viral symptoms are mild, consider stopping if viral symptoms worsen or high fever develops | |
Monoclonal antibodies | Secukinumab (IL-17a) | |||
Monoclonal antibodies | Ixekizumab (IL-17a) | |||
Monoclonal antibodies | Ustekinumab (IL-12/23) | |||
Monoclonal antibodies | Guselkumab (IL-23) | |||
Monoclonal antibodies | Anti-CD20 antibody | Rituximab | Likely concerning risk | Consider stopping when viral symptoms present especially with known or potential exposure. |
PDE4 inhibition | Apremilast | Likely low risk | Continue unless severe symptoms present |
IL, Interleukin; NF-κB, nuclear factor κB; PDE4, phosphodiesterase 4.
General considerations only, medication use should be considered based on each individual patient's risk and disease profile.
Currently, there are no data describing the benefits or risks of stopping immunomodulators/immunosuppressants during the COVID-19 outbreak. However, each medication's mechanism of action, administration method/frequency, and pharmacokinetics/pharmacodynamics are important to consider. Nonbiologic medications, including small molecule inhibitors and immunosuppressants, are typically easier to stop and restart within days to weeks due to shorter half-life. Meanwhile, biologics generally have a longer half-life and include a risk of antidrug antibody formation with treatment cessation and subsequent continuation. However, biologics also tend to be more targeted and less involved in the previously mentioned components of the viral immune response. General medication considerations are included in Table I. Although patient dependent, clinicians may consider weaning patients with stable disease off of immunosuppressants.
Shared decision making is needed when deciding on a treatment plan that includes immunomodulators/immunosuppressants during the COVID-19 outbreak. Patients with existing comorbidities may require more conservative measures.5 Physicians should continue to consult with the Centers for Disease Control and Prevention Information for Healthcare Providers, which is updated daily (https://www.cdc.gov/coronavirus/2019-nCoV/hcp/index.html). Once again, we thank the authors for raising awareness of patient concerns during this evolving outbreak.
Footnotes
Funding sources: None.
Conflicts of interest: Dr Shi is a stock shareholder of Learn Health and has served as an advisory board member, investigator, and/or received research funding from Sanofi Genzyme, Regeneron, AbbVie, Eli Lilly,Novartis, Sun Pharma, LEO Pharma, Pfizer, Menlo Therapeutics, Burt’s Bees, GpSkin, Altus Labs, and Skin Actives Scientific. There were no incentives or transactions, financial or otherwise, relevant to this manuscript. Kyla N. Price and Drs Frew and Hsiao have no conflicts of interest to declare.
IRB approval status: Not applicable.
Accepted for publication March 20, 2020.
Reprints not available from the authors.
References
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