FIG 5.

MX1 is not directly targeted by the miRNA-pool. IPA was performed to investigate the connection between the miRNA pool (miR-125b, miR-221, and miR-579) and the MX1 protein. Filters were set to only include experimentally observed or high-confidence-predicted miRNA-mRNA interaction partners. Output was limited to 13 total candidates. The newly found miRNA targets were interconnected using all available data sources in IPA with restriction to experimentally validated or high-confidence-predicted interactions. Direct or indirect relationships between molecules are indicated by solid or dashed lines, respectively. Blue lines depict positive regulations, while red lines indicate negative regulations. Molecule classes (cytokine, enzyme, ion channel, ligand-dependent nuclease, phosphatase, transcription factor, other, or mature miRNAs) are indicated by distinct symbols.