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Revised model for the early, prereplication events in flavivirus infection (modified from Fig. 1A). After fusion, the nucleocapsid is exposed to the cytosol, where capsid protein (green circles) is presumably ubiquitinated (red hexagons), leading to VCP/p97-dependent nucleocapsid disassembly and release of the viral genome prior to translation. Inhibitors used in this study are indicated. The dotted line indicates the range where VCP/p97 functions in flavivirus entry.
