To the editor,
Dear Editor, we found that the article on Bioactive Lipids Inactivate Coronavirus (COVID-19)? is very interesting (1). Das noted that “Oral or intravenous administration of AA and other unsaturated fatty acids may aid in enhancing resistance and recovery from SARS-CoV-2, SARS and MERS infections (1).” Das UN, et al. discussed on complex inflammatory process in new disease and possible role of bioactive lipids. In fact, if bioactive lipid is useful, there must be a pathway showing interrelationship between bioactive lipids pharmacological actions and virus pathogenesis process. Possible unwanted adverse effect of bioactive lipids should be mentioned. The effects on platelet and thromohemotasis system might occur (2) and this might superimpose the thrombohmostatic disorder in COVID-19 (3). This topic is the interesting issue for further research.
Conflict of Interest
None.
(ARCMED_2020_397)
References
- 1.Das U.N. Can Bioactive Lipids Inactivate Coronavirus (COVID-19)? Arch Med Res. 2020 doi: 10.1016/j.arcmed.2020.03.004. (Epub ahead of print) [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Goodnight S.H., Jr. Effects of dietary fish oil and omega-3 fatty acids on platelets and blood vessels. Semin Thromb Hemost. 1988;14:285–289. doi: 10.1055/s-2007-1002790. [DOI] [PubMed] [Google Scholar]
- 3.Lippi G., Plebani M., Henry B.M. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. Clin Chim Acta. 2020;506:145–148. doi: 10.1016/j.cca.2020.03.022. [DOI] [PMC free article] [PubMed] [Google Scholar]