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. 2010 Apr 21;85(7):541–544. doi: 10.1002/ajh.21742

Analysis of the REL, BCL11A, and MYCN proto‐oncogenes belonging to the 2p amplicon in chronic lymphocytic leukemia

Clara Deambrogi 1, Lorenzo De Paoli 1, Marco Fangazio 1, Stefania Cresta 1, Silvia Rasi 1, Valeria Spina 1, Valter Gattei 2, Gianluca Gaidano 1, Davide Rossi 1,
PMCID: PMC7159449  PMID: 20575024

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Conflict of interest: Nothing to report

References

  • 1. Döhner H,Stilgenbauer S,Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1919–1916. [DOI] [PubMed] [Google Scholar]
  • 2. Schwaenen C,Nessling M,Wessendorf S, et al. Automated array‐based genomic profiling in chronic lymphocytic leukemia: Development of a clinical tool and discovery of recurrent genomic alterations. Proc Natl Acad Sci USA 2004; 101: 1039–1044. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3. Pfeifer D,Pantic M,Skatulla I, et al. Genome‐wide analysis of DNA copy number changes and LOH in CLL using high‐density SNP arrays. Blood 2007; 109: 1202–1210. [DOI] [PubMed] [Google Scholar]
  • 4. Forconi F,Rinaldi A,Kwee I, et al. Genome‐wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion. Br J Haematol 2008; 143: 532–536. [DOI] [PubMed] [Google Scholar]
  • 5. Chapiro E,Leporrier N,Radford‐Weiss I, et al. Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages. Leuk Res 2010; 34: 63–68. [DOI] [PubMed] [Google Scholar]
  • 6. Haferlach C,Dicker F,Schnittger S, et al. Comprehensive genetic characterization of CLL: A study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotyping. Leukemia 2007; 21: 2442–2451. [DOI] [PubMed] [Google Scholar]
  • 7. Cheson BD,Bennett JM,Grever M, et al. National Cancer Institute‐ Sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment. Blood 1996; 87: 4990–4997. [PubMed] [Google Scholar]
  • 8. Matutes E,Owusu‐Ankomah K,Morilla R, et al. The immunological profile of B‐cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia 1994; 8: 1640–1645. [PubMed] [Google Scholar]
  • 9. Rossi D,Spina V,Cerri M,Rasi S, et al. Stereotyped B‐cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome. Clin Cancer Res 2009; 15: 4415–4422. [DOI] [PubMed] [Google Scholar]
  • 10. Rossi D,Cerri M,Deambrogi C, et al. The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: Implications for overall survival and chemorefractoriness. Clin Cancer Res 2009; 15: 995–1004. [DOI] [PubMed] [Google Scholar]
  • 11. Gattei V,Bulian P,Del Principe MI, et al. Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia. Blood 2008; 111: 865–873. [DOI] [PubMed] [Google Scholar]

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