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. 2007 Oct 5;54(Suppl 57):146–159. doi: 10.1111/j.1398-9995.1999.tb04418.x

The common cold and asthma

N Mygind 1,✉, J M Gwaltney Jr 2, B Winther 2, J Owen Hendley 2
PMCID: PMC7159479  PMID: 10565492

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References

  • 1. Corne JM, Holgate ST. Mechanisms of virus induced exacerbations of asthma. Thorax 1997; 52: 380–389. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2. Johnston S. Viruses and asthma. Eur J Allergy Clin Immunol 1997; 53: 922–932. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3. Folkert G., Busse WW, Nijkamp FP, Sorkness R., Gern JE. Virus‐induced airway hyperresponsiveness and asthma. Am Rev Respir Crit Care Med 1998; 157: 1708–1720. [DOI] [PubMed] [Google Scholar]
  • 4. Gwaltney JM Jr, Ruckert RR. Rhinovirus In: Richman DD, Whitley RJ, Hayden FG, editors. Clinical virology. New York : Churchill Livingstone, 1997: 1025–1047. [Google Scholar]
  • 5. Rossman MG, Palmenberg AC. Conservation of the putative receptor attachment site in picornaviruses. Virology 1988; 164: 373–382. [DOI] [PubMed] [Google Scholar]
  • 6. Hendley JO, Gwaltney JM Jr. Mechanisms of transmission of rhinovirus infection. Epidemiol Rev 1988; 10: 242–258. [PubMed] [Google Scholar]
  • 7. Dingle JH, Badger GF, Jordan WS Jr. Illness in the home. A study of 25,000 illnesses in a group of Cleveland families. Cleveland : The Press of Western Reserve University, 1964. [Google Scholar]
  • 8. Hendley JO, Gwaltney JM Jr, Jordan WS Jr. Rhinovirus infections in an industrial population. IV. Infections within families of employees during two fall peaks of respiratory illness. Am J Epidemiol 1969; 89: 184–196. [DOI] [PubMed] [Google Scholar]
  • 9. Gwaltney JM Jr, Moskalski PB, Hendley JO. Hand‐to‐hand transmission of colds. Ann Intern Med 1978; 88: 463. [DOI] [PubMed] [Google Scholar]
  • 10. Gwaltney JM Jr, Moskalski PB, Hendley JO. Interruption of experimental rhinovirus transmission. J Infect Dis 1980; 142: 811. [DOI] [PubMed] [Google Scholar]
  • 11. Gwaltney JM Jr, Hendley JO. Transmission of experimental rhinovirus infection by contaminated surfaces. Am J Epidemiol 1982; 116: 828. [DOI] [PubMed] [Google Scholar]
  • 12. Hayden GF, Hendley OJ, Gwaltney JM Jr. The effect of placebo and virucidal paper handkerchiefs on viral contamination of the hand and transmission of experimental rhinoviral infection. J Infect Dis 1985; 152: 403. [DOI] [PubMed] [Google Scholar]
  • 13. Gem JE, Galagan DM, Jarjour NN, Dick EC, Busse WW. Detection of rhinovirus RNA in lower airway cells during experimentally induced infection. Am J Respir Crit Care Med 1997; 155: 1159–1161. [DOI] [PubMed] [Google Scholar]
  • 14. Østberg B., Winther B., Mygind N. Cold air‐induced rhinorrhea and high‐dose ipratropium. Arch Otorhinolaryngol 1987; 113: 160–162. [DOI] [PubMed] [Google Scholar]
  • 15. Winther B., Gwaltney JM Jr, Mygind N., Turner RB, Hendley JO. Sites of rhinovirus recovery after point‐inoculation of the upper airways. JAMA 1986; 256: 1763–1767. [PubMed] [Google Scholar]
  • 16. Arruda E., Mifflin TE, Gwaltney JM, Winther B., Hayden FG. Localization of rhinovirus replication in vitro with in situ hybridization. J Med Virol 1991; 34: 38–44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17. Arruda E., Boyle TR, Winther B., Pevear DC, Gwaltney JM Jr, Hayden FG. Localization of human rhinovirus replication in the upper respiratory tract by in situ hybridization. J Infect Dis 1995; 171: 1329–1333. [DOI] [PubMed] [Google Scholar]
  • 18. Turner RB, Hendley JO, Gwaltney JM Jr. Shedding of infected ciliated epithelial cells in rhinovirus colds. J Infect Dis 1982; 145: 849. [DOI] [PubMed] [Google Scholar]
  • 19. Bardin PG, Johnston SL, Sanderson G., et al. Detection of rhinovirus infection of the nasal mucosa by oligonucleotide in situ hybridization. Am J Respir Cell Mol Biol 1994; 10: 207–213. [DOI] [PubMed] [Google Scholar]
  • 20. Turner RB, Winther B., Hendley JO, Mygind N., Gwaltney JM Jr. Sites of virus recovery and antigen detection in epithelial cells during experimental rhinovirus infection. Acta Otolaryngol (Stockh) 1984; Suppl. 413: 9–14. [DOI] [PubMed] [Google Scholar]
  • 21. Greve JM, Davis G., Mayer AM. The major human rhinovirus receptor is ICAM‐1. Cell 1989; 56: 839. [DOI] [PubMed] [Google Scholar]
  • 22. Ciprandi G., Pronzato C., Ricca V., Bagnasco M., Canonica GW. Evidence of intracellular adhesion molecule‐1 expression on nasal epithelial cells in acute rhinoconjunctivitis caused by pollen exposure. J Allergy Clin Immunol 1994; 99: 738–746. [DOI] [PubMed] [Google Scholar]
  • 23. Winther B., Greve JM, Gwaltney JM Jr, et al. Surface expression of ICAM‐1 on epithelial cells in the human adenoid. J Infect Dis 1997; 176: 523–525. [DOI] [PubMed] [Google Scholar]
  • 24. Campell AM, Vignola AM, Chanez P. HLA‐DR and ICAM‐1 expression on bronchial epithelial cells in asthma and chronic bronchitis. Am Rev Respir Dis 1993; 148: 689–694. [DOI] [PubMed] [Google Scholar]
  • 25. Winther B., Gwaltney JM Jr, Hendley JO. Respiratory virus infection of monolayer cultures of human nasal epithelial cells. Am Rev Respir Dis 1990; 141: 839–845. [DOI] [PubMed] [Google Scholar]
  • 26. Hoorn B., Tyrrell DA. Effects of some viruses on ciliated cells. Am Rev Respir Dis 1966; 93: 156–161. [DOI] [PubMed] [Google Scholar]
  • 27. Becker S., Soukup J., Yankaskas JR. Respiratory syncytial virus infection of human primary nasal and bronchial epithelial cell cultures and bronchoalveolar macrophages. Am J Respir Cell Mol Biol 1992; 6: 369–374. [DOI] [PubMed] [Google Scholar]
  • 28. Hilding A. The common cold. Arch Otolaryngol 1930; 12: 133–150. [Google Scholar]
  • 29. Winther B., Brofeldt S., Christensen B., Mygind N. Light and scanning electron microscopy of nasal biopsy material from patients with naturally acquired common colds. Acta Otolaryngol (Stockh) 1984; 97: 309–318. [DOI] [PubMed] [Google Scholar]
  • 30. Winther B., Brofeldt S., Grønborg H., Mygind N., Pedersen M., Vejlsgaard R. Study of bacteria in the nasal cavity and nasopharynx during naturally ascuired common colds. Acta Otolaryngol (Stockh) 1984; 98: 315–320. [DOI] [PubMed] [Google Scholar]
  • 31. Carson JL, Collier AM, Hu SS. Acquired ciliary defects in nasal epithelium of children with acute viral upper respiratory infections. N Engl J Med 1985; 312: 463–468. [DOI] [PubMed] [Google Scholar]
  • 32. Persson CGA. Asthma the important questions: epithelial cells, barrier functions and shedding‐restitution mechanisms. Am J Respir Crit Care Med 1999. (In press). [DOI] [PubMed] [Google Scholar]
  • 33. Pedersen M., Sakakura Y., Winther B., Brofeldt S., Mygind N. Nasal mucociliary transport, number of ciliated cells, and beating pattern in naturally acquired common colds. Eur Respir J 1983; 64 (Suppl. 128): 355–364. [PubMed] [Google Scholar]
  • 34. Bryan WTK, Bryan MP, Smith CA. Human ciliated epithelial cells in nasal secretions. Ann Otol Rhinol Laryngol 1964; 73: 474. [DOI] [PubMed] [Google Scholar]
  • 35. Afzelius B. Ultrastructure of human nasal epithelium during an episode of coronavirus infection. Virch Arch 1994; 424: 295–300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 36. Winther B., Farr B., Turner RB, Hendley JO, Gwaltney JM Jr, Mygind N. Histopathologic examination and enumeration of polymorphonuclear leukocytes in the nasal mucosa during experimental rhinovirus colds. Acta Otolaryngol (Stockh) 1984; Suppl. 413: 19–24. [DOI] [PubMed] [Google Scholar]
  • 37. Fraenkel DJ, Bardin PG, Sanderson G., Lampe F., Johnston SL, Holgate ST. Immunohistochemical analysis of nasal biopsies during rhinovirus experimental colds. Am J Respir Crit Care Med 1994; 150: 1130–1136. [DOI] [PubMed] [Google Scholar]
  • 38. Naclerio RM, Proud D., Lichtenstein LM, et al. Kinins are generated during experimental rhinovirus colds. J Infect Dis 1988; 157: 133–142. [DOI] [PubMed] [Google Scholar]
  • 39. Levandowski RA, Ou DW, Jackson GG. Acute‐phase decrease of T‐lymphocyte subsets in rhinovirus infection. J Infect Dis 1986; 153: 743–748. [DOI] [PubMed] [Google Scholar]
  • 40. Cheung D., Dick EC, Timmers MC, de Klerk EPA, Spaan WJM, Sterk PJ. Rhinovirus inhalation causes long‐lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo. Am J Respir Crit Care Med 1995; 152: 1490–1496. [DOI] [PubMed] [Google Scholar]
  • 41. Fraenkel DJ, Bardin PG, Sanderson G., Lampe F., Johnston SL, Holgate ST. Lower airways inflammation during rhinovirus colds in normal and asthmatic subjects. Am J Respir Crit Care Med 1995; 151: 879–886. [DOI] [PubMed] [Google Scholar]
  • 42. Winther B., Innes DF, Bratsch J., Hayden FG. Lymphocyte subsets in the nasal nasal mucosa and peripheral blood during experimental rhinovirus infection. Am J Rhinol 1992; 6: 149–156. [Google Scholar]
  • 43. Skoner DP, Whiteside TL, Wilson JW, Doyle WJ, Herberman RB, Fireman P. Effect of rhinovirus 39 infection on cellular immune parameters in allergic and nonallergic subjects. J Allergy Clin Immunol 1993; 92: 732–743. [DOI] [PubMed] [Google Scholar]
  • 44. Vianna EO, Westcott J., Martin RJ. The effects of upper respiratory infection on T‐cell proliferation and steroid sensitivity in asthmatics. J Allergy Clin Immunol 1998; 102: 592–597. [DOI] [PubMed] [Google Scholar]
  • 45. Gwaltney Jr JM, Hendley JO, Turner RB, et al. Symposium on rhinovirus pathogenesis. Acta Otolaryngol (Stockh) 1984; Suppl. 413: 5–45. [DOI] [PubMed] [Google Scholar]
  • 46. Winther B. The effect on the nasal mucosa of respiratory viruses (common cold). Dan Med Bull 1994; 41: 193–204. [PubMed] [Google Scholar]
  • 47. Subauste MC, Jacoby DB, Richards SM, Proud D. Infection of a human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure. J Clin Invest 1995; 96: 549–557. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 48. Zhu Z., Tang W., Gwaltney JM Jr, Elias JA. Rhinovirus stimulation of interleukin‐8 in vivo and in vitro: role of NF‐kappaB. Am J Physiol 1997; 273: L814–L824. [DOI] [PubMed] [Google Scholar]
  • 49. Turner RB. Rhinovirus infection of human embryonic lung fibroblast induces the production of a chemoattractant for polymorphonuclear leukocytes. J Infect Dis 1988; 157: 346–350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 50. Röseler S., Holtappels G., Wagenmann M., Bachert C. Elevated levels of interleukins IL‐Ibeta, IL‐6 and IL‐8 in naturally acquired viral rhinitis. Eur Arch Otorhinolaryngol 1995; 252: (Suppl. 1) S61–S63. [DOI] [PubMed] [Google Scholar]
  • 51. Noah TL, Henderson FW, Wortman IA, et al. Nasal cytokine production in viral acute upper respiratory infection of childhood. J Infect Dis 1995; 171: 584–792. [DOI] [PubMed] [Google Scholar]
  • 52. Turner RB, Weingand KW, Yeh CH, Leedy DW. Association between interleukin‐8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds. Clin Infect Dis 1998; 26: 840–846. [DOI] [PubMed] [Google Scholar]
  • 53. Choi AMK, Jacoby DB. Influenza virus A infection induces interleukin‐8 gene expression in human airway epithelial cells. FEBS Lett 1992; 309: 327–329. [DOI] [PubMed] [Google Scholar]
  • 54. Kenney JS, Baker C., Welch MR, Altman LC. Synthesis of interleukin‐1 alpha, interleukin‐6, and interleukin‐8 by cultured human nasal epithelial cells. J Allergy Clin Immunol 1994; 93: 1060–1067. [DOI] [PubMed] [Google Scholar]
  • 55. Proud D., Gwaltney JM Jr, Hendley JO, Dinarello CA, Gillis S., Schleimer RP. Increased levels of interleukin‐1 are detected in nasal secretions of volunteers during experimental rhinovius colds. J Infect Dis 1994; 169: 1007–1013. [DOI] [PubMed] [Google Scholar]
  • 56. Zhu Z., Tang W., Ray A., et al. Rhinovirus stimulation of interleukin‐6 in vivo and in vitro: evidence for NFKB‐dependent transcriptional activation. J Clin Invest 1996; 97: 421–430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 57. Cheung D., Hiemstra PS, Dick EC, de Klerk EPA, Sterk PJ. Effects of experimental rhinovirus infection on IL‐8 in nasal washings in asthmatic subjects in vivo. Eur Respir J 1994; 7: 481s. [Google Scholar]
  • 58. Teran L., Johnston S., Shute J., Church M., Holgate S. Increased levels of interleukin‐8 in nasal aspirates of children with viral associated asthma. J Allergy Clin Immunol 1994; 93: 272. [Google Scholar]
  • 59. Lau L., Corne J., Scott S., Davies R., Friend E., Howarth P. Nasal cytology in the common cold. Am J Respir Crit Care Med 1996; 153: A697. [Google Scholar]
  • 60. Muraguchi A., Hirano T., Tang B., et al. The essential role of B cell stimulatory factor 2 (BSF‐2/IL‐6) for the terminal differentiation of B cells. J Exp Med 1988; 167: 332–344. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 61. Linden M., Greiff L., Andersson M., et al. Nasal cytokines in common cold and allergic rhinitis. Clin Exp Allergy 1995; 25: 166–172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 62. Proud D., Naclerio RM, Gwaltney JM Jr, Hendley JO. Kinins are generated in nasal secretions during natural rhinovirus colds. J Infect Dis 1990; 161: 120–123. [DOI] [PubMed] [Google Scholar]
  • 63. Proud D., Reynolds CJ, Lacapra S., Kagey‐Sobotka A., Lichtenstein LM, Naclerio RM. Nasal provocation with bradyldnin induces symptoms of rhinitis and a sore throat. Am Rev Respir Dis 1988; 137: 613–616. [DOI] [PubMed] [Google Scholar]
  • 64. Eggleston PA, Hendley JO, Gwaltney JM Jr, Eggleston AW, Leavell BS Jr. Histamine in nasal secretions. Arch Allergy Appl Immunol 1978; 57: 193–200. [DOI] [PubMed] [Google Scholar]
  • 65. Naclerio RM, Proud D., Kagey‐Sobotka A., Lichtenstein LM, Hendley JO, Gwaltney JM Jr. Is histamine responsible for the symptoms of rhinovirus colds? A look at the inflammatory mediators following infection. Pediatr Infect Dis J 1988; 7: 218–222. [DOI] [PubMed] [Google Scholar]
  • 66. Igarashi Y., Skoner DP, Fireman P., Kaliner MA. Analysis of nasal secretions during experimental rhinovirus upper respiratory infections. J Allergy Clin Immunol 1993; 92: 722–731. [DOI] [PubMed] [Google Scholar]
  • 67. Smith MB, Feldman W. Over‐the‐counter cold medications. A critical review of clinical trial between 1950 and 1991. JAMA 1993; 269: 2258–2263. [DOI] [PubMed] [Google Scholar]
  • 68. Eccles R., van Cauwenberge P., Tetzloff W., Borum P. A clinical study to evaluate the efficacy of the antihistamine doxylamine succinate in the relief of runny nose and sneezing associated with upper respiratory tract infection. J Pharm Pharmacol 1995; 47: 990–993. [DOI] [PubMed] [Google Scholar]
  • 69. Gwaltney JM Jr, Park J., Paul RA, Edelman DA, O'Connor RR, Turner RB. Randomized controlled trial of clemastine fumarate for treatment of experimental rhinovirus colds. Clin Infect Dis 1996; 22: 656–662. [DOI] [PubMed] [Google Scholar]
  • 70. Gwaltney JM Jr, Druce HM. Efficacy of brompheniramine maleate treatment for rhinovirus colds. Clin Infect Dis 1997; 25: 1188–1194. [DOI] [PubMed] [Google Scholar]
  • 71. Bisgaard H., Olsson P., Bende M. Effect of leukotriene D4 on nasal mucosal blood flow, nasal airway resistance and nasal secretion in humans. Clin Allergy 1986; 16: 289–298. [DOI] [PubMed] [Google Scholar]
  • 72. Lundgren JD, Shelhammer JH, Pathogenesis of airway mucus hypersecretion. J Allergy Clin Immunol 1990; 85: 399–417. [DOI] [PubMed] [Google Scholar]
  • 73. Doyle WJ, Boehm S., Skoner DP. Physiologic response to intranasal dose‐response challenge with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy. J Allergy Clin Immunol 1990; 86: 924–935. [DOI] [PubMed] [Google Scholar]
  • 74. Sperber SJ, Hendley JO, Hayden FG, Riker DK, Sorrentino JV, Gwaltney GM Jr. Effects of naproxen on experimental rhinovirus colds. Ann Intern Med 1992; 117: 37. [DOI] [PubMed] [Google Scholar]
  • 75. Winther B., Mygind N. Placebo‐controlled trial of the effect of ibuprofen on the symptoms of naturally acquired common cold. 1999. (in preparation).
  • 76. Grønborg H., Borum P., Winther B., Mygind N. Nasal methacholine and histamine reactivity during a common cold. Eur J Respir Dis 1983; 64 (Suppl. 128): 406–408. [PubMed] [Google Scholar]
  • 77. Doyle WJ, Skoner DP, Seroky JT, Fireman P., Gwaltney JM. Effect of experimental rhinovirus 39 infection on the nasal response to histamine and cold air challenges in allergic and nonallergic subjects. J Allergy Clin Immunol 1994; 93: 534–542. [DOI] [PubMed] [Google Scholar]
  • 78. Greiff L., Andersson M., Åkerlund A., et al. Microvascular exudative hyperresponsiveness in human coronavirus‐induced common cold. Thorax 1994; 49: 121–127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 79. Gwaltney JM Jr, Phillips CD, Miller RD, Riker DK. Computed tomographic study of the common cold. N Engl J Med 1994; 330: 25–30. [DOI] [PubMed] [Google Scholar]
  • 80. Hayden FG, Albrecht JK, Kaiser DL, Gwaltney JM Jr. Prevention of natural colds by contact prophylaxis with intranasal alpha2‐interferon. N Engl J Med 1986; 314: 71. [DOI] [PubMed] [Google Scholar]
  • 81. Hayden FG, Gwaltney JM Jr. Intranasal interferon‐alpha2 treatment of experimental rhinoviral colds. J Infect Dis 1984; 150: 174–180. [DOI] [PubMed] [Google Scholar]
  • 82. Farr BM, Gwaltney JM Jr, Hendley JO, et al. A randomized controlled trial of glucocorticoid prophylaxis against experimental rhinovirus infection. J Infect Dis 1990; 162: 1173–1177. [DOI] [PubMed] [Google Scholar]
  • 83. Puhakka T., Makela MJ, Malmström K., et al. The common cold: effect of intranasal fluticasone propionate treatment. J Allergy Clin Immunol 1998; 101: 726–731. [DOI] [PubMed] [Google Scholar]
  • 84. Gustafson LM, Proud D., Hendley JO, Hayden FG, Gwaltney JM Jr. Oral prednisone therapy in experimental rhinovirus infections. J Allergy Clin Immunol 1996; 97: 1009–1014. [DOI] [PubMed] [Google Scholar]
  • 85. Grønborg H., Winther B., Brofeldt S., Mygind N. Effects of oral norephedrine on common cold symptoms. Rhinology 1983; 21: 3–12. [PubMed] [Google Scholar]
  • 86. Åkerlund A., Klint T., Olén L., Runderantz H. Nasal decongestant effect of oxymethazoline in the common cold: an objective dose‐response study in 106 patients. J Laryngol Otol 1989; 103: 743–746. [DOI] [PubMed] [Google Scholar]
  • 87. Sperber SJ, Sorrentino JV, Riker DK, Hayden FG. Evaluation of an alpha agonist alone and in combination with a nonsteroidal antiinflammatory agent in the treatment of experimental rhinovirus colds. Bull NY Acad Med 1989; 65: 145–160. [PMC free article] [PubMed] [Google Scholar]
  • 88. Borum P., Olsen L., Winther B., Mygind N. Ipratropium nasal spray: a new treatment for rhinorrhea in the common cold. Am Rev Respir Dis 1981; 123: 418–420. [DOI] [PubMed] [Google Scholar]
  • 89. Gwaltney JM Jr. Combined antiviral and antimediator treatment of rhinovirus colds. J Infect Dis 1992; 166: 776–782. [DOI] [PubMed] [Google Scholar]
  • 90. Pattemore PK, Johnston SL, Bardin PG. Viruses as precipitants of asthma symptoms. I. Epidemiology. Clin Exp Allergy 1992; 22: 325–336. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 91. Minor TE, Dick EC, Baker JW, Ouellette JJ, Cohen M., Reed CE. Rhinovirus and influenza type A infections as precipitants of asthma. Am Rev Respir Dis 1976; 113: 149–153. [DOI] [PubMed] [Google Scholar]
  • 92. Johnston S., Pattemore PK, Sanderson G., et al. Community study of role of viral infections in exacerbations of asthma in 9–11‐year‐old children. Br Med J 1995; 310: 1225–1229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 93. Nicholson KG, Kent J., Ireland DC. Respiratory viruses and exacerbations of asthma in adults. Br Med J 1993; 307: 982–986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 94. Trigg CJ, Nicholson KG, Wang JH, et al. Bronchial inflammation and the common cold: a comparison of atopic and non‐atopic individuals. Clin Exp Allergy 1996; 26: 665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 95. Lemanske RF, Dick EC, Swenson CA, Vrtis RF, Busse WW. Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions. J Clin Invest 1989; 83: 1–10. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 96. Gern JE, Calhoun W., Swenson C., Shen G., Busse WW. Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects. Am J Respir Crit Care 1997; 155: 1872–1876. [DOI] [PubMed] [Google Scholar]
  • 97. Grünberg K., Timmers MC, Smits HH, et al. Effect of experimental rhinovirus 16 on airway hyperresponsiveness to histamine and interleukin‐8 in nasal lavage in asthmatic subjects in vivo. Clin Exp Allergy 1997; 27: 36–45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 98. Skoner DP, Doyle WJ, Seroky J., Van Deusen MA, Fireman P. Lower airway responses to rhinovirus 39 in healthy allergic and nonallergic subjects. Eur Respir J 1996; 9: 1402–1406. [DOI] [PubMed] [Google Scholar]
  • 99. Grünberg K., Smits HH, Timmers MC, et al. Experimental rhinovirus 16 infection. Effects on cell differentials and soluble markers in sputum in asthmatic subjects. Am J Respir Crit Care Med 1997; 156: 609–616. [DOI] [PubMed] [Google Scholar]
  • 100. Handzel ZT, Busse WW, Sedgwick JB, et al. Eosinophils bind rhinovirus and activate virus‐specific T cells. J Immunol 1998; 160: 1279–1284. [PubMed] [Google Scholar]
  • 101. Busse WW, Calboun WJ, Dick EC. Effect of an experimental rhinovirus 16 infection on airway mediator response to antigen. Int Arch Allergy Immunol 1992; 99: 422–424. [DOI] [PubMed] [Google Scholar]
  • 102. Calhoun WJ, Dick EC, Schwartx LB, Busse WW. A common cold, rhinovirus 16, potentiates airway inflammation after segmental antigen bronchoprovocation in allergic subjects. J Clin Invest 1994; 94: 2200–2208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 103. Calhoun WJ, Swenson CA, Dick EC, Schwartz LB, Lemanske RF, Busse WW. Experimental rhinovirus 16 infections potentiates histamine release after antigen bronchoprovocation in allergic subjects. Am Rev Respir Dis 1991; 144: 1267–1273. [DOI] [PubMed] [Google Scholar]
  • 104. Halperin SA, Eggleston PA, Hendley JO, et al. Pathogenesis of lower respiratory tract symptoms in experimental rhinovirus infection. Am Rev Respir Dis 1983; 128: 806. [DOI] [PubMed] [Google Scholar]
  • 105. Gern JE, Lemanske Jr RF, Busse WW. The role of rhinoviruses in virus‐induced asthma In: Marone G., Austen KF, Holgate ST, Kay AB, Lichtenstein LM, editors. Asthma and allergic diseases. San Diego : Academic Press, 1998: 293–307. [Google Scholar]
  • 106. Einarsson O., Geba GP, Zhu Z., Landry M., Elias JA. Interleukin‐11: stimulation in vivo and in vitro by respiratory virusus and induction of airways hyperresponsiveness. J Clin Invest 1996; 97: 915–924. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 107. Balfour‐Lynn L., Valman H., Wellings R., et al. Tumour necrosis factor‐α and leukotriene E4 production in wheezy infants. Clin Exp Allergy 1994; 24: 121–126. [DOI] [PubMed] [Google Scholar]
  • 108. Shannon V., Chanez P., Bousquet J., et al. Histochemical evidence for induction of arachidonate 15‐lipoxygenase in airways disease. Am Rev Respir Dis 1993; 147: 1024–1028. [DOI] [PubMed] [Google Scholar]
  • 109. Butler GB, Adler KB, Evans JN. Modulation of rabbit airway smooth muscle responsiveness by respiratory epithelium. Am Rev Respir Dis 1987; 135: 1099–1097. [DOI] [PubMed] [Google Scholar]
  • 110. Hinriksdottir I., Melen I. Allergic rhinitis and upper respiratory tract infections. Acta Otolaryngol (Stockh) 1994; Suppl. 515: 30–32. [DOI] [PubMed] [Google Scholar]
  • 111. Corley DL. Prevention of postinfectious asthma in children by reducing self‐inoculatory behavior. J Pediatr Psychol 1987; 12: 519–531. [DOI] [PubMed] [Google Scholar]
  • 112. McFadden Jr ER. Dosages of corticosteroids in asthma. Am Rev Respir Dis 1993; 147: 1306–1310. [DOI] [PubMed] [Google Scholar]
  • 113. Engel T., Heinig JH. Glucocorticoid therapy in acute severe asthma ‐ a critical review. Eur Respir J 1991; 4: 881–889. [PubMed] [Google Scholar]
  • 114. Brunette MG, Lands L., Thibodeau LP. Childhood asthma: prevention of attacks with short‐term corticosteroid treatment of upper airway respiratory tract infection. Pediatrics 1988; 81: 624–629. [PubMed] [Google Scholar]
  • 115. Doull IJM, Lampe FC, Smith S., Schreiber J., Freezer NJ, Holgate ST. Effect of inhaled corticosteroids on episodes of wheezing associated with viral infection in school age children: randomized double blind placebo controlled trial. Br Med J 1997; 315: 858–862. [DOI] [PMC free article] [PubMed] [Google Scholar]

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