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. 2009 Jan 29;80(1):46–50. doi: 10.1111/j.1600-0404.1989.tb03841.x

Risk factors in multiple sclerosis: a population‐based case‐control study in Hautes‐Pyrénées, France

C Berr 1,, J Puel 2, M Clanet 3, J B Ruidavets 3, J L Mas 1, A Alperovitch 1
PMCID: PMC7159688  PMID: 2782041

Abstract

ABSTRACT‐ A population‐based study of the prevalence and risk factors of multiple sclerosis (MS) was conducted in the Hautes‐Pyrénées, the southwestern region of France. The prevalence rate per 100,000 was equal to 40. Data on the past medical history of 63 MS patients and matched controls were collected. The frequency and age at occurrence of common childhood infections were similar for both the MS cases and controls. There was no difference between the frequency of vaccination for MS patients and for controls. However, the age at which MS patients were immunized against poliomyelitis was significantly higher than the corresponding age for controls (15.8 years versus 8.9 years, P < 0.01). Antibody titers for various viruses were measured. The mumps antibody titer was significantly higher in the MS patients than in the controls. Also, MS patients tended to have higher titers for measles antibodies.

Keywords: multiple sclerosis, epidemiology, viral antibodies

REFERENCES

  • 1. Alpérovitch A, Bouvier MH. Geographical pattern of death rates from multiple sclerosis in France. Acta Neurol Scand 1982:66:454–461. [DOI] [PubMed] [Google Scholar]
  • 2. Poser CM, Paty DW, Scheinberg L et al. New diagnostic criteria for multiple sclerosis. Guidelines for research protocols. Ann Neurol 1983:13:227–231. [DOI] [PubMed] [Google Scholar]
  • 3. Fleiss JL. Statistical methods for rates and proportions. New York : John Wiley, 1981:212–236. [Google Scholar]
  • 4. Kurtzke JF. On the evaluation of disability in multiple sclerosis. Neurology 1961:11:686–694. [DOI] [PubMed] [Google Scholar]
  • 5. Kurtzke JF. The geographic distribution of multiple sclerosis: an up‐date with special reference to Europe and the Mediterranean region. Acta Neurol Scand 1980:62:65–80. [DOI] [PubMed] [Google Scholar]
  • 6. Nelson LM, Franklin GM, Hamman RF, Boteler DL, Baum HM, Burks JS. Referral bias in multiple sclerosis research. J Clin Epidemiol 1988:41:187–192. [DOI] [PubMed] [Google Scholar]
  • 7. Shepherd DI. Clinical features of multiple sclerosis in north east Scotland. Acta Neurol Scand 1979:60:218–230. [DOI] [PubMed] [Google Scholar]
  • 8. Confavreux C, Aimard G, Devic M. Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients. Brain 1980:103:281–300. [DOI] [PubMed] [Google Scholar]
  • 9. Poskanser DC, Sheridan JL, Prenney LB, Walker AM. Multiple sclerosis in the Orkney and Shetland Islands. II - The search for an exogenous aetiology. J Epid Commun Health 1980:34:240–252. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10. Alpérovitch A, Le Canuet P, Marteau R. Birth order and risk of multiple sclerosis: Are they associated and how? Acta Neurol Scand 1981:63:136–138. [DOI] [PubMed] [Google Scholar]
  • 11. Russel WR. Multiple sclerosis: occupation and social group at onset. Lancet 1971:2:832–834. [DOI] [PubMed] [Google Scholar]
  • 12. Lauer K, Firnhaber W. Epidemiological investigation into multiple sclerosis in Southern Hesse. III - The possible influence of occupation on the risk of disease. Acta Neurol Scand 1985:72:397–402. [PubMed] [Google Scholar]
  • 13. Antonovsky A, Leibovitz U, Medalie JM, Smith HA, Halpern L, Alter M. Epidemiological study of multiple sclerosis in Israel. II. Multiple-sclerosis and socio-economic status. J Neurol Neurosurg Psychiat 1967:30:1–6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14. Alter M, Yamsor M, Harshe M. Multiple sclerosis and nutrition. Arch Neurol 1974:31:267–272. [DOI] [PubMed] [Google Scholar]
  • 15. Agranoff BW, Goldberg D. Diet and the geographical distribution of multiple sclerosis. Lancet 1974:2:1061–1066. [DOI] [PubMed] [Google Scholar]
  • 16. Cook SD, Dowling PC. A possible association between house pets and multiple sclerosis. Lancet 1977 May: 7:980–982. [DOI] [PubMed] [Google Scholar]
  • 17. Alter M, Berman M, Kahana E. The year of the dog. Neurology 1979:29:1023–1026. [DOI] [PubMed] [Google Scholar]
  • 18. Norman JE, Cook SD, Dowling PC. Household pets among veterans with multiple sclerosis and age‐matched controls. Arch Neurol 1983:40:213–214. [DOI] [PubMed] [Google Scholar]
  • 19. Visscher BR, Bunnell DH, Detels R. Multiple sclerosis and multiple moves: an etiologic hypothesis. Am J Epidemiol 1981:113:140–143. [DOI] [PubMed] [Google Scholar]
  • 20. Sibley WA, Bamford CR, Clark K. Clinical viral infections and multiple sclerosis. Lancet 1985 June: 8:1313–1315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21. Andersen E, Isager H, Hyllested K. Risk factors in multiple sclerosis: tuberculin reactivity, age at measles infection, tonsillectomy and appendicectomy. Acta Neurol Scand 1981:63:131–139. [DOI] [PubMed] [Google Scholar]
  • 22. Poser S, Raun NE, Wikström J, Poser W. Pregnancy, oral contraceptives and multiple sclerosis. Acta Neurol Scand 1979:59:108–118. [DOI] [PubMed] [Google Scholar]
  • 23. Poser S, Poser W. Multiple sclerosis and gestation. Neurology 1983:33:1422–1427. [DOI] [PubMed] [Google Scholar]
  • 24. Talal N, Dauphinee MJ, Ahmed SA, Christados P. Sex factors in immunity and autoimmunity. In: Yamamura Y, Toda D, eds. 5th Int Cong Immunol. New York : Academic Press, 1983:1589–1600. [Google Scholar]
  • 25. Van Lambalgen R, Sanders EACM, D'Amaro J. Sex distribution, age of onset and HLA profiles in two types of multiple sclerosis. J Neurol Sci 1986:76:13–21. [DOI] [PubMed] [Google Scholar]
  • 26. Alter M. Is multiple sclerosis an age‐dependent host response to measles? Lancet 1976:1:456–457. [DOI] [PubMed] [Google Scholar]
  • 27. Fewster ME, Myers LW, Ellison GW, Walford RL. Histocompatibility types and measles antibodies in multiple sclerosis. J Neurol Sci 1977:34:287–296. [DOI] [PubMed] [Google Scholar]
  • 28. Compston DAS, Vakarelis BN, Paul E, Mc Donald WI, Batchelor JR, Mims CA. Viral infection in patients with multiple sclerosis and HLA‐DR matched controls. Brain 1986:109:325–344. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29. Alter M, Cendrowski W. Multiple sclerosis and childhood infections. Neurology 1976:26:201–204. [DOI] [PubMed] [Google Scholar]
  • 30. Poskanser DC, Sever JL, Sheridan JL, Prenney LB. Multiple sclerosis in the Orkney and Shetland Islands. IV: viral antibody titres and viral infections. J Epid Commun Health 1980:34:258–264. [DOI] [PMC free article] [PubMed] [Google Scholar]

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