Title {1}	Impact of nationwide enhanced implementation of best practices in pancreatic cancer care (PACAP-1): a multicenter stepped-wedge cluster randomized controlled trial
Trial registration {2a and 2b}.	Trial open for accrual 22th May 2018. ClinicalTrials.gov - NCT03513705.
Protocol version {3}	Protocol version 6.4 – May 2018
Funding {4}	This research was funded by a grant from the Dutch Cancer Society (grant number UVA2013-5842).
Author details {5a}	TM Mackay: Department of surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam FJ Smits: Department of surgery, University Medical Center Utrecht, Utrecht AEJ Latenstein: Department of surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam A Bogte: Department of gastroenterology, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht & St. Antonius Hospital Nieuwegein BA Bonsing: Department of surgery, Leiden University Medical Center, Leiden H Bos: Department of medical oncology, Tjongerschans Hospital, Heerenveen K Bosscha: Department of surgery, Jeroen Bosch Hospital, Den Bosch LAA Brosens: Department of pathology, University Medical Center Utrecht, Utrecht; and Department of pathology, Radboud University, Nijmegen L Hol: Department of gastroenterology, Maasstad Hospital, Rotterdam ORC Busch: Department of surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam GJ Creemers: Department of medical oncology, Catharina Hospital, Eindhoven WL Curvers: Department of gastroenterology, Catharina Hospital, Eindhoven M den Dulk: Department of surgery, Maastricht UMC+, Maastricht S van Dieren: Department of surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam LMJW van Driel: Department of gastroenterology, Erasmus Medical Center, Rotterdam S Festen: Department of surgery, OLVG, Amsterdam EJM van Geenen: Department of gastroenterology, Radboud UMC, Nijmegen LG van der Geest: Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht DJA de Groot: Department of medical oncology, University Medical Center Groningen JWB de Groot: Department of medical oncology, Oncology Center Isala, Zwolle N Haj Mohammad: Department of medical oncology, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht & St. Antonius Hospital Nieuwegein BCM Haberkorn: Department of medical oncology, Maasstad Hospital, Rotterdam JT Haver: Department of nutrition and dietetics, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam E van der Harst: Department of surgery, Maasstad Hospital, Rotterdam GJM Hemmink: Department of gastroenterology, Oncology Center Isala, Zwolle IH de Hingh: Department of surgery, Catharina Hospital, Eindhoven C Hoge: Department of gastroenterology, Maastricht UMC+, Maastricht MYV Homs: Department of medical oncology, Erasmus Medical Center, Rotterdam NC van Huijgevoort: Department of gastroenterology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam MAJM Jacobs: Department of gastroenterology, Cancer Center Amsterdam, Amsterdam UMC, VU Medical Center ED Kerver: Department of medical oncology, OLVG, Amsterdam MSL Liem: Department of surgery, Medisch Spectrum Twente, Enschede M Los: Department of medical oncology, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht & St. Antonius Hospital Nieuwegein H Lubbinge: Department of gastroenterology, Tjongerschans Hospital, Heerenveen SAC Luelmo: Department of medical oncology, Leiden University Medical Center, Leiden VE de Meijer: Department of surgery, University Medical Center Groningen, Groningen L Mekenkamp: Department of medical oncology, Medisch Spectrum Twente, Enschede IQ Molenaar: Department of surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht & St. Antonius Hospital Nieuwegein MGH van Oijen: Department of medical oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam GA Patijn: Department of surgery, Oncology Center Isala, Zwolle R Quispel: Department of gastroenterology, Reinier de Graaf Hospital, Delft LB van Rijssen: Department of surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam TEH Römkens: Department of gastroenterology, Jeroen Bosch Hospital, Den Bosch HC van Santvoort: Department of surgery, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht & St. Antonius Hospital Nieuwegein JMJ Schreinemakers: Department of surgery, Amphia Hospital, Breda H Schut: Department of medical oncology, Jeroen Bosch Hospital, Den Bosch T Seerden: Department of gastroenterology, Amphia Hospital, Breda MWJ Stommel: Department of surgery, Radboud UMC, Nijmegen AJ ten Tije: Department of medical oncology, Amphia Hospital, Breda NG Venneman: Department of gastroenterology and hepatology, Medisch Spectrum Twente, Enschede RC Verdonk: Department of gastroenterology, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht & St. Antonius Hospital Nieuwegein J Verheij: Department of pathology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam FGI van Vilsteren: Department of gastroenterology, University Medical Center Groningen, Groningen J de Vos-Geelen: Department of medical oncology, Maastricht UMC+, Maastricht A Vulink: Department of medical oncology, Reinier de Graaf Hospital, Delft C Wientjes: Department of gastroenterology, OLVG, Amsterdam F Wit: Department of surgery, Tjongerschans Hospital, Heerenveen FJ Wessels: Department of radiology, Regional Academic Cancer Center Utrecht, University Medical Center Utrecht & St. Antonius Hospital Nieuwegein B Zonderhuis: Department of surgery, Cancer Center Amsterdam, Amsterdam UMC, VU Medical Center CH van Werkhoven: Julius Center for Health Sciences and primary care, University Medical Center Utrecht, Utrecht University JE van Hooft: Department of gastroenterology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam CHJ van Eijck: Department of surgery, Erasmus Medical Center, Rotterdam JW Wilmink: Department of medical oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam HWM van Laarhoven: Department of medical oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam MG Besselink: Department of surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam
Name and contact information for the trial sponsor {5b}	Dutch Cancer Society (https://www.kwf.nl/node/20)
Role of sponsor {5c}	The Dutch Cancer Society played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.