Figure 5.

PepO enhanced unspecific phagocytosis and bactericidal activity of macrophage. Murine primary macrophages were treated with PepO and then infected with S. pneumoniae (MOI = 100), S. aureus (MOI = 100), and P. aeruginosa, respectively (MOI = 50). (a, c and e) PepO enhanced macrophage phagocytosis against S. pneumoniae, S. aureus, and P. aeruginosa, respectively, in a dose-dependent manner. (b, d, and f) PepO enhanced macrophage bactericidal activity against the three species referred above. Data were shown as mean with SEM (n = 3) and are representative of three independent experiments. ns: not significant; *p < 0.05; **p < 0.01. Statistically significant differences were carried out by Student’s t-test.