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. 2016 Feb 17;14(2):4375. doi: 10.2903/j.efsa.2016.4375

Collection and review of updated scientific epidemiological data on porcine epidemic diarrhoea

European Food Safety Authority (EFSA)
PMCID: PMC7163754  PMID: 32313572

Abstract

Porcine epidemic diarrhoea (PED) is a non‐zoonotic viral disease of pigs caused by a coronavirus and characterised by watery diarrhoea and weight loss. PED is not notifiable to the EU or World Organisation for Animal Health listed but it is notifiable at the national level in Finland, France, Ireland and Sweden. PED case reports from seven countries and PED surveillance and monitoring activities in thirteen countries were reported. This information was combined with an extensive literature review to provide an update on global PED occurrence, circulating strains and impact in 2014–2015. PED confirmed cases have been reported in North America, South America, Asia and Europe. PED virus (PEDV) sequences originating from EU pig herds indicate that the strains currently in circulation share nearly 100% sequence identity and have greater than 99% sequence identity with the reference INDEL (insertion/deletion) strain USA/OH851/2014. In 2014–2015, greater genetic variability has been reported in strains circulating in Asia compared with EU Member States and a non‐INDEL strain has been detected in the Ukraine in 2014. Data on impact confirms that mortality is higher in suckling piglets and diarrhoea is observed in all age groups. The reported impact is in agreement with that reported in EFSA AHAW Panel (2014) indicating that the impact of recently reported PED outbreaks in Asia and the USA seems to be more severe than that described in EU countries, although the impact of different PEDV strains is difficult to compare between one country and another, as impact is dependent not only on pathogenicity but also on factors such as biosecurity, herd size, farm management, sanitary status or herd immune status.

Keywords: porcine epidemic diarrhoea, PED, pig herds, impact

Suggested citation: EFSA (European Food Safety Authority) , 2016. Scientific Report on the collection and review of updated epidemiological data on porcine epidemic diarrhoea. EFSA Journal 2016;14(2):4375. 52 pp. doi: 10.2903/j.efsa.2016.4375

Correspondence: AMU@efsa.europa.eu

Acknowledgement: EFSA wishes to thank the members of the EFSA Network on PED: Adolf Steinrigl, Brigitte Cay, Hans Nauwynck, Lowiese Desmarets, Isaura Christiaens, Sebastiaan Theuns, Yves Van der Stede, Anette Bøtner, Bertel Strandbygaard, Dragan Brnic, Imbi Nurmoja, Triin Tedersoo, Taina Laine, Laura London, Beatrice Grasland, Nicolas Rose, Loic Evain, Clara Marce, Sandra Blome, Bernd‐Andreas Schwarz, Spyridon Kritas, Paschalis Fortomaris, Adam Balint, Adam Dan, John Moriarty, Eoin Ryan, Antonio Lavazza, Giovanni Alborali, Beatrice Boniotti, Monica Cerioli, Marius Masiulis, Patrıcia Isabel Vilhena Clemente, Yolanda Vaz, Maria Jorge Correia, Wim van der Poel, Peter van der Wolf, Carl Andreas Grøntvedt, Berit Tafjord Heier, Anna Ondrejkova, Miroslav Mojzis, Dalibor Polak, Luis Romero, Beatriz Gonzalo Martınez, Cecilia Hulten, Falko Steinbach, Helen Roberts, Susanna Williamson, Paul Franssen, German Caseres Garrido for the preparatory work on this scientific output, the peerreviewer: Klaus Depner and EFSA staff members: Jane Richardson, Marios Georgiadis, Andrea Gervelmeyer, Frank Verdonck, Franck Berthe, Andrea Baù, Jose Cortiñas Abrahantes, Diana Tashkova and Roberta Palumbo for the support provided to this scientific output.

Adoption date: 18 December 2015

Published date: 17 February 2016

Question number: EFSA‐Q‐2015‐00125, EFSA‐Q‐2015‐00160

On request from: European Commission

References

  1. ANPROGAPOR – Dirección General de Sanidad de la Producción Agraria , 2014. Impact of PEDV outbreaks on pork production. Unpublished report.
  2. Alvarez J, Sarradell J, Morrison R and Perez A, 2015. Impact of porcine epidemic diarrhea on performance of growing pigs. PLoS ONE, 10, e0120532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boniotti BM, Papetti A, Lavazza A, Alborali G, Sozzi E, Chiapponi C, Faccini S, Bonilauri P, Cordioli P and Marthaler D, 2016. Porcine epidemic diarrhea virus and discovery of a recombinant swine enteric coronaviruses, Italy. Emerging Infectious Diseases, 22, 10.3201/eid2201.150544. [DOI] [PMC free article] [PubMed]
  4. Bowman AS, Krogwold RA, Price T, Davis M and Moeller SJ, 2015. Investigating the introduction of porcine epidemic diarrhea virus into an Ohio swine operation. BMC Veterinary Research, 11, 38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cheney T, Powell L, Steinbach F and Williamson S, 2014. Study of Porcine Epidemic Diarrhoea Virus in UK Pigs at Slaughter in 2013. Animal Health and Veterinary Laboratories Agency, http://development.bpex.org.uk/?R-and-D/Pig-Health/pedv.aspx [Google Scholar]
  6. Cheun‐Arom T, Temeeyasen G, Srijangwad A, Tripipat T, Sangmalee S, Vui DT, Chuanasa T, Tantituvanont A and Nilubol D, 2015. Complete genome sequences of two genetically distinct variants of porcine epidemic diarrhea virus in the Eastern Region of Thailand. Genome Announcements, 3. [DOI] [PMC free article] [PubMed]
  7. Chiou HY, Huang YL, Deng MC, Chang CY, Jeng CR, Tsai PS, Yang C, Pang VF and Chang HW, 2015. Phylogenetic analysis of the spike (s) gene of the new variants of porcine epidemic diarrhoea virus in Taiwan. Transboundary and Emerging Diseases. doi: 10.1111/tbed.12357 [DOI] [PubMed]
  8. Collin EA, Anbalagan S, Okda F, Batman R, Nelson E and Hause BM, 2015. An inactivated vaccine made from a U.S. field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose‐titration. BMC Veterinary Research, 11, 62. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Dastjerdi A, Carr J, Ellis RJ, Steinbach F and Williamson S, 2015. Porcine epidemic diarrhea virus among farmed pigs, Ukraine. Emerging Infectious Diseases, 21, 2235–2237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. EFSA AHAW Panel (EFSA Panel on Animal Health and Welfare) , 2014. Scientific Opinion on porcine epidemic diarrhoea and emerging pig deltacoronavirus. EFSA Journal 2014; 12(10): 3877, 68 pp. doi:10.2903/j.efsa.2014.3877 [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. EUROSTAT , 2014. Pig farming in the European Union: considerable variations from one Member State to another. Statistics in Focus, ISSN 2314–9647.
  12. Grasland B, Bigault L, Bernard C, Quenault H, Toulouse O, Fablet C, Rose N, Touzain F and Blanchard Y, 2015. Complete genome sequence of a porcine epidemic diarrhea S gene Indel strain isolated in France in December 2014. Genome Announcements, 3, e00535–15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hanke D, Jenckel M, Petrov A, Ritzmann M, Stadler J, Akimkin V, Blome S, Pohlmann A, Schirrmeier H, Beer M and Höper D, 2015. Comparison of porcine epidemic diarrhea viruses from Germany and the United States, 2014. Emerging Infectious Diseases, 21, 493–496. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kim S‐H, Kim I‐J, Pyo H‐M, Tark D‐S, Song J‐Y and Hyun B‐H, 2007. Multiplex real‐time RT‐PCR for the simultaneous detection and quantification of transmissible gastroenteritis virus and porcine epidemic diarrhea virus. Journal of Virological Methods, 146, 172–177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kim YK, Lim SI, Lim JA, Cho IS, Park EH, Le VP, Hien NB, Thach PN, Quynh do H, Vui TQ, Tien NT and An DJ, 2015a. A novel strain of porcine epidemic diarrhea virus in Vietnamese pigs. Archives of Virology, 160, 1573–1577. [DOI] [PubMed] [Google Scholar]
  16. Kim SH, Lee JM, Jung J, Kim IJ, Hyun BH, Kim HI, Park CK, Oem JK, Kim YH, Lee MH and Lee KK, 2015b. Genetic characterization of porcine epidemic diarrhea virus in Korea from 1998 to 2013. Archives of Virology, 160, 1055–1064. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Knuchel M, Ackermann M, Müller HK and Kihm U, 1992. An ELISA for detection of antibodies against porcine epidemic diarrhoea virus (PEDV) based on the specific solubility of the viral surface glycoprotein. Veterinary Microbiology, 32, 117–134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Lavazza A, Tittarelli C and Cerioli M, 2015. The use of convalescent sera in immune‐electron microscopy to detect non‐suspected/new viral agents. Viruses, 7, 2683–2703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Laranjo M, Allepuz A, Pleguezuelos P, López S, Casal J, Segalés J, Martín M and Pujols J, 2015. Estudio epidemiologico prospectivo en granjas con brotes recientes de diarrea epidemica porcina, 95 pp. Unpublished report.
  20. Lee S, Park GS, Shin JH and Lee C, 2014. Full‐genome sequence analysis of a variant strain of porcine epidemic diarrhea virus in South Korea. Genome Announcements, 2. [DOI] [PMC free article] [PubMed]
  21. Makita K, Toyomaki H, Sekiguchi S, Sasaki Y and Sueyoshi M, 2015. Spatio‐temporal analysis of spread of porcine epidemic diarrhea (PED) in Kagoshima and Miyazaki Prefecture. Japan Journal of Veterinary Epidemiology, 19, 24–25. [Google Scholar]
  22. McCarty M, Petznick T, Kuster C, Bower L, Zhang J, Yoon K‐J and Madson D, 2015. Case report describing the clinical course of porcine epidemic diarrhea in a commercial boar stud and return of the stud to service after whole‐herd inoculation with porcine epidemic diarrhea virus. Journal of Swine Health and Production, 23, 264–271. [Google Scholar]
  23. Marthaler D, Bruner L, Collins J and Rossow K, 2014. Third strain of porcine epidemic diarrhea virus, United States. Emerging Infectious Diseases, 20, 2162–2163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Masuda T, Murakami S, Takahashi O, Miyazaki A, Ohashi S, Yamasato H and Suzuki T, 2015. New porcine epidemic diarrhoea virus variant with a large deletion in the spike gene identified in domestic pigs. Archives of Virology, 160, 2565–2568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Mesquita JR, Hakze‐van der Honing R, Almeida A, Lourenço M, van der Poel WHM and Nascimento MSJ, 2015. Outbreak of porcine epidemic diarrhea virus in Portugal, 2015. Transboundary and Emerging Diseases, 62, 586–588, doi:10.1111/tbed.12409 [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Misener M, 2015. Technologies to meet market demands. Proceedings of the London Swine Conference Production, 5–10.
  27. Murakami S, Miyazaki A, Takahashi O, Hashizume W, Hase Y, Ohashi S and Suzuki T, 2015. Complete genome sequence of the porcine epidemic diarrhea virus variant Tottori2/JPN/2014. Genome Announcements, 3. [DOI] [PMC free article] [PubMed]
  28. van Nieuwstadt AP and Zetstra T, 1991. Use of two enzyme‐linked immunosorbent assays to monitor antibody responses in swine with experimentally induced infection with porcine epidemic diarrhea virus. American Journal of Veterinary Research, 52, 1044–1050. [PubMed] [Google Scholar]
  29. Ojkic D, Hazlett M, Fairles J, Marom A, Slavic D, Maxie G, Alexandersen S, Pasick J, Alsop J and Burlatschenko S, 2015. The first case of porcine epidemic diarrhea in Canada. Canadian Veterinary Journal, 56, 149–152. [PMC free article] [PubMed] [Google Scholar]
  30. Oka T, Saif LJ, Marthaler D, Esseili MA, Meulia T, Lin CM, Vlasova AN, Jung K, Zhang Y and Wang Q, 2014. Cell culture isolation and sequence analysis of genetically diverse US porcine epidemic diarrhea virus strains including a novel strain with a large deletion in the spike gene. Veterinary Microbiology, 173, 258–269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Park S, Kim S, Song D and Park B, 2014. Novel porcine epidemic diarrhea virus variant with large genomic deletion, South Korea. Emerging Infectious Diseases, 20, 2089–2092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Pensaert M and de Bouck P, 1978. A new coronavirus‐like particle associated with diarrhea in swine. Archives of Virology, 58, 243–247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Piñeros R and Mogollón Galvis JD, 2015. Coronavirus in pigs: significance and presentation of swine epidemic diarrhea virus (PEDV) in Colombia. Revista de Medicina Veterinaria, 29, 73–89. [Google Scholar]
  34. Song D, Chen Y, Peng Q, Huang D, Zhang T, Huang T, Zhang F, Zhou X and Tang Y, 2014. Full‐length genome sequence of a variant porcine epidemic diarrhea virus strain, CH/GDZQ/2014, responsible for a severe outbreak of diarrhea in piglets in Guangdong, China, 2014. Genome Announcements, 2. [DOI] [PMC free article] [PubMed]
  35. Song D, Zhou X, Peng Q, Chen Y, Zhang F, Huang T, Zhang T, Li A, Huang D, Wu Q, He H and Tang Y, 2015a. Newly emerged porcine deltacoronavirus associated with diarrhoea in Swine in China: identification, prevalence and full‐length genome sequence analysis. Transboundary and Emerging Diseases, 62, 575–580. doi:10.1111/tbed.12399 [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Song D, Huang D, Peng Q, Huang T, Chen Y, Zhang T, Nie X, He H, Wang P, Liu Q and Tang Y, 2015b. Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea viruses associated with outbreaks of severe diarrhea in piglets in Jiangxi, China 2013. PLoS ONE, 10, e0120310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Sozzi E, Alborali L, Luppi A, Lelli D, Moreno A, Cordioli P and Brocchi E, 2007. ELISA con anticorpi monoclonali per la diagnostica sierologica della diarrea epidemica suina (PED). Atti Convegno SIPAS, 33, 415–420. [Google Scholar]
  38. Sozzi E, Luppi A, Lelli D, Moreno Martin A, Canelli E, Brocchi E, Lavazza A and Cordioli P, 2010. Comparison of enzyme‐linked immunosorbent assay and RT‐PCR for the detection of porcine epidemic diarrhoea virus. Research in Veterinary Science, 88, 166–168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Stadler J, Zoels S, Fux R, Hanke D, Pohlmann A, Blome S, Weissenböck H, Weissenbacher‐Lang C, Ritzmann M and Ladining A, 2015. Emergence of porcine epidemic diarrhea virus in southern Germany. BMC Veterinary Research, 11, 142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Steinrigl A, Revilla Fernández S, Stoiber F, Pikalo J, Sattler T and Schmoll F, 2015. First detection, clinical presentation and phylogenetic characterization of Porcine epidemic diarrhea virus in Austria. BMC Veterinary Research, 11:310. doi:10.1186/s12917‐015‐0624‐1 [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Sun M, Ma J, Wang Y, Wang M, Song W, Zhang W, Lu C and Yao H, 2015. Genomic and epidemiological characteristics provide new insights into the phylogeographical and spatiotemporal spread of porcine epidemic diarrhea virus in Asia. Journal of Clinical Microbiology, 53, 1484–1492. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Sung MH, Deng MC, Chung YH, Huang YL, Chang CY, Lan YC, Chou HL and Chao DY, 2015. Evolutionary characterization of the emerging porcine epidemic diarrhea virus worldwide and 2014 epidemic in Taiwan. Infection, Genetics and Evolution, 36, 108–115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Suzuki T, Murakami S, Takahashi O, Kodera A, Masuda T, Itoh S, Miyazaki A, Ohashi S and Tsutsui T, 2015. Molecular characterization of pig epidemic diarrhoea viruses isolated in Japan from 2013 to 2014. Infection, Genetics and Evolution. [DOI] [PubMed]
  44. Theuns S, Conceicão‐Neto N, Christiaens I, Zeller M, Desmarets LMB, Roukaerts IDM, Acar DD, Heylen E, Matthijnssens J and Nauwynck HJ, 2015. Complete genome sequence of a porcine epidemic diarrhea virus from a novel outbreak in Belgium, January 2015. Genome Announcements, 3, e00506–15. doi:10.1128/genomeA.00506‐15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Tian PF, Jin YL, Xing G, Qv LL, Huang YW and Zhou JY, 2014. Evidence of recombinant strains of porcine epidemic diarrhea virus, United States, 2013. Emerging Infectious Diseases, 20, 1735–1738. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Toplak I, Stukelj M, Rihtaric D, Hostnik P and Grom J, 2015. First detection of porcine diarrhea virus in Slovenia, 2015.
  47. USDA, Animal and Plant Health Inspection Service , 2015. Swine Enteric Coronavirus Disease (SECD) Situation Report – Nov 26, 2015.
  48. Vlasova AN, Marthaler D, Wang Q, Culhane MR, Rossow KD, Rovira A, Collins J and Jung K, 2014. Distinct characteristics and complex evolution of PEDV strains, North America, May 2013‐February 2014. Emerging Infectious Diseases, 20, 1620–1628. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Vui DT, Thanh TL, Tung N, Srijangwad A, Tripipat T, Chuanasa T and Nilubol D, 2015. Complete genome characterization of porcine epidemic diarrhea virus in Vietnam. Archives of Virology, 160, 1931–1938. [DOI] [PubMed] [Google Scholar]
  50. Wang L, Byrum B and Zhang Y, 2014. New variant of porcine epidemic diarrhoea virus, United States. Emerging Infectious Diseases, 20, 917–919. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Wang Y, Gao X, Yao Y, Zhang Y, Lv C, Sun Z, Wang Y, Jia X, Zhuang J, Xiao Y, Li X and Tian K, 2015. The dynamics of Chinese variant porcine epidemic diarrhea virus production in Vero cells and intestines of 2‐day old piglets. Virus Research, 208, 82–88. [DOI] [PubMed] [Google Scholar]
  52. Yamakawa DVMM, 2014. 2014 Porcine Epidemic Diarrhea (PED) Joint FAO/OIE Workshop on Swine Disease Control in Asia.
  53. Yang DQ, Ge FF, Ju HB, Wang J, Liu J, Ning K, Liu PH, Zhou JP and Sun QY, 2014. Whole‐genome analysis of porcine epidemic diarrhea virus (PEDV) from eastern China. Archives of Virology, 159, 2777–2785. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Zhang X, Pan Y, Wang D, Tian X, Song Y and Cao Y, 2015. Identification and pathogenicity of a variant porcine epidemic diarrhea virus field strain with reduced virulence. Virology Journal, 12, 88. [DOI] [PMC free article] [PubMed] [Google Scholar]

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