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. 2006 Jul 28;1(2):43–64. doi: 10.1111/j.1741-2358.1982.tb00336.x

Age‐Associated Lesions in Barrier‐Reared Male Sprague‐Dawley Rats: A Comparison Between Hap: (SD) and Crl:COBS[R]CD[R] (SD)Stocks 1, , 6

Miriam R Anver 1, Bennett J Cohen 2, Charles P Lattuada 3, Sumner J Foster 4
PMCID: PMC7165504

Abstract

Age‐associated lesions were characterized in two outbred stocks of barrier‐reared male Sprague‐Dawley rats. Seventy‐two virgin Hap:(SD) between 6–29 months of age and 113 retired breeder Crl:COBS[R]CD[R](SD) between 12–38 months of age were evaluated for the presence of lesions in all major organ systems. Rats of both stocks developed a spectrum of neoplastic, inflammatory and degenerative diseases with highest prevalence in the oldest age groups. In general, the shorter‐lived Hap:(SD) rats had greater incidences and severity of lesions when compared to Crl:COBS[R]CD[R]SD of similar ages. Many of these differences were not apparent when the two stocks were compared over their respective life spans. The study provides baseline pathology data relevant to the use of these rats in gerontologic research.

1

Supported in part by National Institutes of Health grants RR 00200 and AG‐00368, and by contract NO‐1‐AG 6‐2136. The authors gratefully acknowledge the technical assistance of Gail Renard, Lois Craig, and Jane Haack; and the advice of Dr. D.H. Ringler, Dr. G.D. Abrams, and Dr. R.C. Adelman.

6

Reprinted from Experimental Aging Research, Volume 8, Number 1, 1982 with permission of the authors and the publisher.

REFERENCES

  • 1. Altman, N.H. , & Goodman, D.G. Neoplastic diseases Chpt. 13. In Baker H.J., Lindsey J.R. & Weisbroth S.H., (Eds.), The laboratory rat. Vol I. Biology and diseases. New York : Academic Press, 1979. [Google Scholar]
  • 2. Andrew, W. Senile changes in the pancreas of Wistar Institute rats and of man with special regard to the similarity of locule and cavity formation. American Journal of Anatomy, 1944, 74, 97–125. [Google Scholar]
  • 3. Andrew, W. , & Andrew, N.V. Age changes in the deep cervical lymph nodes of 100 Wistar Institute rats. American Journal of Anatomy, 1948, 82, 105–165. [DOI] [PubMed] [Google Scholar]
  • 4. Anver, M.R. , & Cohen, B.J. Lesions associated with aging Chpt. 14. In Baker H.J., Lindsey J.R. & Weisbroth S.H., (Eds.), The laboratory rat. Vol. I. Biology and diseases. New York : Academic Press, 1979. [Google Scholar]
  • 5. Baker, H.J. , Lindsey, J.R. , & Weisbroth, S.H. Housing to control research variables In Baker H.J., Lindsey J.R. & Weisbroth S.H.(Eds.), The laboratory rat. Vol. I. Biology and diseases. New York : Academic Press, 1979. [Google Scholar]
  • 6. Bannasch, P. Cytology and cytogenesis of neoplastic (hyperplastic) hepatic nodules. Cancer Research, 1976, 36, 2555–2562. [PubMed] [Google Scholar]
  • 7. Berg, B.N. Longevity studies in rats. II. Pathology of aging In Cotchin E. & Roe F.J.C., (Eds.), Pathology of laboratory rats and mice. Philadelphia : Davis, 1967. [Google Scholar]
  • 8. Berg, B.N. , Wolf, A. , & Simms, H.S. Degenerative lesions of spinal roots and peripheral nerves in aging rats. Gerontologia, 1962, 6, 72–80. [DOI] [PubMed] [Google Scholar]
  • 9. Bilder, G.E. Studies on immune competence in the rat: Changes with age, sex and strains. Journal of Gerontology, 1975, 30, 641–646. [DOI] [PubMed] [Google Scholar]
  • 10. Boorman, G.A. , Zurcher, C. , & Hollander, C.F. Naturally occurring endocardial disease in the rat. Archives of Pathology, 1973, 96, 39–45. [PubMed] [Google Scholar]
  • 11. Boorman, G.A. , & Hollander, C.F. High incidence of spontaneous urinary bladder and ureter tumors in the Brown Norway rat. Journal of the National Cancer Institute, 1974, 52, 1005–1008. [DOI] [PubMed] [Google Scholar]
  • 12. Burek, J.D. Pathology of aging in rats. West Palm Beach , FL : CRC Press, Inc., 1978. [Google Scholar]
  • 13. Burek, J.D. , & Hollander, C.F. Experimental gerontology Chpt. 7. In Baker H.J., Lindsey J.R. & Weisbroth S.H., (Eds.), The laboratory rat. Vol. II. Research applications. New York : Academic Press, 1980. [Google Scholar]
  • 14. Burek, J.D. , van DerKogel, A.J. , & Hollander, C.F. Degenerative myelopathy in three strains of aging rats. Veterinary Pathology, 1976, 13, 321–331. [DOI] [PubMed] [Google Scholar]
  • 15. Cameron, T.P. , Lattuada, C.P. , Harlan, H.P. , & Tarone, R.E. Survival and reproductive comparisons for male ACI and–Sprague‐Dawley aging colonies. Abstract 36. In Publication 79‐4. Joliet : American Association for Laboratory Animal Science, 1979. [PubMed] [Google Scholar]
  • 16. Cohen, B.J. Housing and long‐term care of rats for gerontologic research and age‐related lesions and diseases In Gibson D.C., Adelman R.C. & Finch C., (Eds.), Development of the rodent as a model system of aging. Book II. US Dept. Health, Education and Welfare; PHS. DHEW Pub. No. (NIH) 79–161, 1979. [Google Scholar]
  • 17. Cohen, B.J. Letter to the editor. Journal of Gerontology, 1980, 35, 443. [Google Scholar]
  • 18. Cohen, B.J. , Anver, M.R. , Ringler, D.H. , & Adelman, R.C. Age‐associated pathological changes in male rats. Federation Proceedings, 1978, 37, 2848–2850. [PubMed] [Google Scholar]
  • 19. Coleman, G.L. , Barthold, S. , Osbaldiston, G. , Foster, S. , & Jonas, A.M. Pathological changes during aging in barrier reared Fischer 344 male rats. Journal of Gerontology, 1977, 32, 258–278. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20. Committee on Animal Models for Research on Aging , Institute of Laboratory Animal Resources. Rats (pp. 75–132). In Mammalian models for research on aging. Washington , DC : National Academy of Sciences, 1981. [Google Scholar]
  • 21. DeLellis, R.A. , Nunnemacher, G. , Bitman, W.R. , Gagel, R.F. , Tashjian, A.H. , Blount, M. , & Wolfe, H.J. C cell hyperplasia and medullary thyroid carcinoma in the rat. An immunohistochemical and ultrastructural analysis. Laboratory Investigation, 1979, 40, 140–154. [PubMed] [Google Scholar]
  • 22. Fairweather, F.A. Cardiovascular diseases in rats In Cotchin E. & Roe F.J.C., (Eds.), Pathology of laboratory rats and mice. Philadelphia : Davis, 1967. [Google Scholar]
  • 23. Finch, C.E. Guest editorial. Journal of Gerontology, 1977, 32, 257. [Google Scholar]
  • 24. Flodh, H. , Magnusson, G. , & Magnusson, O. Pulmonary foam cells in rats of different ages. Z. Viersuchstierkd, 1974, 16, 299–312. [PubMed] [Google Scholar]
  • 25. Foster, H.L. The history of commercial production of laboratory rodents. Laboratory Animal Science, 1980, 30, Part II, 793–798. [PubMed] [Google Scholar]
  • 26. Geinsman, Y. , Bondareff, W. , & Dodge, J.T. Hypertrophy of astroglial processes in the dentate gyrus of the senescent rat. American Journal of Anatomy, 1978, 153, 537–544. [DOI] [PubMed] [Google Scholar]
  • 27. Gelatt, K.N. , Peiffer, Jr., R.L. , & Williams, L.W. Photoreceptor degeneration (retinitis pigmentosa; progressive cone‐rod degeneration). Part V. Diseases of the eye In Andrews E.J., Ward B.C. & Altman N.H. (Eds.). Spontaneous animal models of human disease, Vol I New York : Academic Press, 1979. [Google Scholar]
  • 28. Gerrity, R.G. , & Cliff, W.J. The aortic tunica intima in young & aging rats. Experimental & Molecular Pathology, 1972, 16, 382–402. [DOI] [PubMed] [Google Scholar]
  • 29. Giddens, W.E. , & Whitehair, C.K. The peribronchial lymphocytic tissue in germfree, defined‐flora, conventional and chronic murine pneumonia‐affected rats In Mirand E.A. & Back N., (Eds.), Germfree biology. New York : Plenum, 1969. [Google Scholar]
  • 30. Gilmore, S.A. Spinal nerve root degeneration in aging laboratory rats: A light microscopic study. Anatomical Record, 1972, 174, 251–257. [DOI] [PubMed] [Google Scholar]
  • 31. Goodman, D.G. , Ward, J.M. , Squire, R.A. , Chu, K.C. , & Linhart, M.S. Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicology and Applied Pharmacology, 1979, 48, 237–248. [DOI] [PubMed] [Google Scholar]
  • 32. Goodman, D.G. , Ward, J.M. , Squire, R.A. , Paxton, M.B. , Reichardt, W.D. , Chu, K.C. , & Linhart, M.S. Neoplastic and non‐neoplastic lesions in aging Osborne‐Mendel rats. Toxicology and Applied Pharmacology, 1980, 55, 433–447. [DOI] [PubMed] [Google Scholar]
  • 33. Gray, J.E. Chronic progressive nephrosis in the albino rat In CRC critical reviews in toxicology. West Palm Beach , FL : CRC Press, Inc., 1977. [DOI] [PubMed] [Google Scholar]
  • 34. Hajdu, A. , Herr, F. , & Rona, G. The functional significance of a spontaneous pancreatic islet change in aged rats. Diabetotogia 1968, 4, 44–47. [DOI] [PubMed] [Google Scholar]
  • 35. Hollander, C.F. Guest editorial: Animal models for aging and cancer research. Journal of the National Cancer Institute, 1973. 51, 3–5. [DOI] [PubMed] [Google Scholar]
  • 36. Hollander, C.F. , & Snell, K.C. Tumors of the adrenal gland of the rat In Turusov V.S., (Ed.), Pathology of tumors in laboratory animals. IARC Scientific Publication; No. 5, Vol I, Part 2 Lyon‐IARC, 1976. [Google Scholar]
  • 37. Institute of Laboratory Animal Resources (ILAR), National Research Council, National Academy of Sciences. Histologic typing of liver tumors of the rat. Journal of the National Cancer Institute, 1980, 64, 179–206. [PubMed] [Google Scholar]
  • 38. Itakura, C. , Ida, M. , & Goto, M. Renal secondary hyperparathyroidism in aged Sprague‐Dawley rats. Veterinary Pathology, 1977, 14, 463–469. [DOI] [PubMed] [Google Scholar]
  • 39. James, R.W. , & Heywood, R. Age‐related variations in the testes of Sprague‐Dawley rats. Toxicology Letters, 1979, 4, 257–261. [DOI] [PubMed] [Google Scholar]
  • 40. Jubb, K.V.F. , & Kennedy, P.C. The circulatory system In Pathology of domestic animals. 2nd ed., Vol. I New York : Academic Press, 1970. [Google Scholar]
  • 41. Lai, Y.L. , Jacoby, R.O. , & Yao, P.C. Animal model of human disease. Peripheral retinal degeneration in rats. American Journal of Pathology, 1979, 97, 449–452. [PMC free article] [PubMed] [Google Scholar]
  • 42. Laver‐Rudich, Z. , Skutelsky, E. , & Danon, D. Age‐related changes in aortic intima of rats. Journal of Gerontology, 1978, 33, 337–346. [DOI] [PubMed] [Google Scholar]
  • 43. Levine, S. , & Deshpande, V. Letter to the editor. The autopsy in experimental gerontology. Journal of Gerontology, 1980, 35, 958–959. [DOI] [PubMed] [Google Scholar]
  • 44. Lindsey, J.R. Historical foundations In Baker H.J., Lindsey J.R. & Weisbroth S.H., (Eds.), The laboratory rat. Vol. I. Biology and diseases. New York : Academic Press, 1979. [Google Scholar]
  • 45. Lutzen, L. , & Ueberberg, H. A study on morphological changes in the testes of old albino rats. Beitr. Pathol., 1973, 149, 377–385. [DOI] [PubMed] [Google Scholar]
  • 46. McMartin, D.N. Morphologic lesions in aging Syrian hamsters. Journal of Gerontology, 1979, 34, 502–511. [DOI] [PubMed] [Google Scholar]
  • 47. McMillan, P.J. , Thaete, L.G. , Hooker, W.M. , & Roos, B.A. Immunohistology, light microscopy, and ultrastructural morphology of transplantable rat medullary thyroid carcinomas. Cancer Research, 1980, 40, 1419–1426. [PubMed] [Google Scholar]
  • 48. Moloney, W.C. , Boschett, A.E. , & King, V.P. Spontaneous leukemia in Fischer rats. Cancer Research, 1970, 30, 40–43. [PubMed] [Google Scholar]
  • 49. Muraoka, Y. , Itoh, M. , Maeda, Y. , & Hayashi, Y. Histological changes of various organs in aged SD‐JCL rats. Experimental Animals, 1977, 26, 1–12. [DOI] [PubMed] [Google Scholar]
  • 50. Peng, M.T. , & Lee, L.R. Regional differences of neuron loss of rat brain in old age. Gerontology, 1979, 25, 205–211. [DOI] [PubMed] [Google Scholar]
  • 51. Prejean, J.D. , Peckman, J.C. , Casey, A.E. , Griswold, D.P. , Weisburger, E.K. , & Weisburger, J.H. Spontaneous tumors in Sprague‐Dawley rats and Swiss mice. Cancer Research, 1973, 33, 2768–2773. [PubMed] [Google Scholar]
  • 52. Reznik, G. , Ward, J.M. , & Reznik‐Schuller, H. Ganglioneuromas in the adrenal medulla of F344 rats. Veterinary Pathology, 1980, 17, 614–621. [DOI] [PubMed] [Google Scholar]
  • 53. Russfield, A.B. Pathology of the endocrine glands, ovary and testes of rats and mice In Cotchin E. & Roe F. J.C., (Eds.), Pathology of laboratory rats and mice. Philadelphia : Davis, 1967. [Google Scholar]
  • 54. Sass, B. , Rabstein, L.S. , Madison, R. , Nims, R.M. , Peters, R.L. , & Kelloff, G. Incidence of spontaneous neoplasms in F344 rats throughout the natural life span. Journal of the National Cancer Institute, 1975, 54, 1449–1456. [DOI] [PubMed] [Google Scholar]
  • 55. Sher, S.P. Mammary tumors in control rats: Literature tabulation. Toxicology and Applied Pharmacology, 1972, 22, 562–588. [DOI] [PubMed] [Google Scholar]
  • 56. Sommers, S.C. Adrenal glands. Chpt. 39 In Anderson W.A.D. & Kissane J.M., (Eds.), Pathology, Vol. 2 7th edition St. Louis : The C.V. Mosby Co., 1977. [Google Scholar]
  • 57. Squire, R.A. , & Levitt, M.H. Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Research, 1975, 35, 3214–3223. [PubMed] [Google Scholar]
  • 58. Thompson, S.W. , Huseby, R.A. , Fox, M.A. , Davis, C.L. , & Hunt, R.J. Spontaneous tumors in the Sprague‐Dawley rat. Journal of the National Cancer Institute, 1961, 27, 1037–1057. [PubMed] [Google Scholar]
  • 59. Val, F. , Fournier, M. , & Pariente, R. Bronchial lymphoepithelial nodules in the rat. Definition and morphological characteristics in optical and electron microscopy. Biomedicine, 1971, 26, 130–137. [PubMed] [Google Scholar]
  • 60. van Steenis, G. , & Kroes, R. Changes in the nervous system and musculature of old rats. Veterinary Pathology, 1971, 8, 320–332. [DOI] [PubMed] [Google Scholar]
  • 61. von Sallmann, L. , & Grimes, P. Retinal degeneration in mature rats. Comparison of the disease in an Osborne‐Mendel and a spontaneous hypertensive Wistar strain. Investigative Ophthalmology, 1974, 13, 1010–1015. [PubMed] [Google Scholar]
  • 62. Wagner, M.M.F. Changes with age in the hematopoietic system in a cesarean‐derived, barrier‐maintained colony of Wistar rats. Journal of the National Cancer Institute, 1976, 57, 501–508. [DOI] [PubMed] [Google Scholar]
  • 63. Ward, J.M. , & Reznik‐Schuller, H. Morphological and histochemical characteristics of pigments in aging F344 rats. Veterinary Pathology, 1980, 17, 678–685. [DOI] [PubMed] [Google Scholar]
  • 64. Wexler, B.C. Co‐existent arteriosclerosis, PAN, and premature aging. Journal of Gerontology, 1970, 25, 373–380. [DOI] [PubMed] [Google Scholar]
  • 65. Wexler, B.C. Spontaneous arteriosclerosis in old, male, virgin Sprague‐Dawley rats. Atherosclerosis, 1979, 34, 277–290. [DOI] [PubMed] [Google Scholar]
  • 66. Williams, G.M. , Klalber, M. , & Farber, E. Differences in growth of transplants of liver, liver hyperplastic nodules, and hepatocellular carcinomas in the mammary fat pad. American Journal of Pathology, 1977, 89, 379–388. [PMC free article] [PubMed] [Google Scholar]
  • 67. Williams, G.M. , Ohmori, T. , & Watanabe, K. The persistence and phenotypic stability of transplanted rat liver neoplastic nodules. American Journal of Pathology, 1980, 99, 1–7. [PMC free article] [PubMed] [Google Scholar]
  • 68. Yang, Y.H. Polyarteritis nodosa in laboratory rats. Laboratory Investigation, 1965, 14, 81–88. [PubMed] [Google Scholar]

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