Figure 5.

Mutation S327A in E1 confers resistance to FQ treatment. Huh‐7 cells were pretreated for 1 hour with FQ before infection with JFH‐1 or mutant viruses Y297H or S327A (MOI, approximately 1), and infected cells were in contact with drug until the end of the experiment. At 48 hours postinfection, infected cells were quantified. Results are expressed as percentage of infection in the presence of solvent. Error bars indicate standard errors of the mean values from at least three independent experiments.