Figure 6.

HAV‐ and HCV‐RNA replication can be inhibited by flavonolignans. Huh7‐Lunet cells were electroporated with HAV or HCV (JFH, Con1, and H77) reporter replicons. First, 4 hours p.t., medium was replaced by DMEM containing SIL (A) or silibinin (B) at indicated concentrations. Then, 48 hours p.t., cells were harvested for measurement of luciferase activity. Graph shows mean and standard deviation of triplicate values of two independent experiments (n = 2). Values are normalized to untreated controls and depicted in logarithmic scale. Abbreviations: p.t., post‐transfection.