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. 2005 Dec 6;3(2):111–118. doi: 10.1002/jmv.1890030204

Rat tracheal organ culture supports replication of parainfluenza 1 (6/94) virus and promotes 6/94 virus rescue from latently infected human brain cells

Zofia Wroblewska 1,✉, Mary Wellish 1, Lucy B Rorke 1, Donald H Gilden 1
PMCID: PMC7166323  PMID: 215718

Abstract

Rat tracheal organ culture (TOC) supported replication of parainfluenza 1 (6/94) virus. Cell‐associated and cell‐free viruses were found after primary infection of TOC. In contrast to other mammalian systems, rat TOC was capable of maintaining 6/94 virus infectivity after primary infection. Rat TOC may be considered a potential indicator system that could be used to detect virus latent in human tissue.

Keywords: latent infection, organ culture, virus rescue

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