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. 2007 Apr 3;4(1):1–12. doi: 10.1111/j.1745-4565.1982.tb00429.x

IN VITRO EFFECTS OF MONOLAURIN COMPOUNDS ON ENVELOPED RNA AND DNA VIRUSES 1

JOHN C HIERHOLZER 1, JON J KABARA 2
PMCID: PMC7166675  PMID: 32336838

Abstract

Monolaurin alone and monolaurin with tert‐butylhydroxyanisole (BHA), methylparaben, or sorbic acid were tested for in vitro virucidal activity against 14 human RNA and DNA enveloped viruses in cell culture. At concentrations of 1% additive in the reaction mixture for 1 h at 23°C, all viruses were reduced in infectivity by >99.9%. Monolaurin with BHA was the most effective virucidal agent in that it removed all measurable infectivity from all of the viruses tested. The compounds acted similarly on all the viruses and reduced infectivity by disintegrating the virus envelope.

1

Use of trade names is for identification only and does not constitute endorsement by the Public Health Service or by the Department of Health and Human Services.

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