Abstract
An 11‐year‐old male castrated Persian cat with spontaneous hyperadrenocorticism was presented. Both adrenals were grossly enlarged and calcified. A diagnosis of pituitary‐dependent hyperadrenocorticism was made. Signs of hyperadrenocorticism resolved with long‐term mitotane treatment. Concurrent diabetes mellitus resolved after 220 days of therapy. No severe adverse drug reactions were noted.
References
- Bruyette, D. S. (1994) Adrenal function testing In: Consultations in Feline Internal Medicine. Ed August J. R. W. B. Saunders; Philadelphia , pp 129–132. [Google Scholar]
 - Daley. C. A. . Zerbe, C. A. , Schick. R. A. & Powers. R. D. (1993) Use of metapyrone to treat pituitary‐dependent hyperadrenocorticism in a cat with large cutaneous wounds. Journal of the American Veterinary Medical Association 202, 956–960. [PubMed] [Google Scholar]
 - Duesberg. C. & Peterson, M. E. (1997) Adrenal disorders in cats. Veterinary Clinics of North America: Small Animal Practice 27 321–347. [DOI] [PubMed] [Google Scholar]
 - Feldman. E. C. (1995) Hyperadrenocorticism In: Textbook of Veterinary Internal Medicine. 4th edn Eds Ettinger S. J. and Feldman. E. C. W. B. Saunders; Philadelphia , pp 1538–1578. [Google Scholar]
 - Feldman, E. C. , Bruyette, D. S. & Nelson, R. W. (1989) Therapy for spontaneous canine hyperadrenocorticism In: Current Veterinary Therapy X. Ed Kirk R. W. W. B. Saunders; Philadelphia , pp 1024–1031. [Google Scholar]
 - Feldman, E. C. & Nelson. R. W. (1987) Hyperadrenocorticism In: Canine and Feline Endocrinology and Reproduction. Eds Feldman E. C. and Nelson. R. W. W. B. Saunders, Philadelphia , pp 137–194. [Google Scholar]
 - Helton‐Rhodes, K. . Wallace. M. & Baer, K. (1993) Cutaneous manifestations of feline hyperadrenocorticism In: Advances in Veterinary Dermatology. Vol 2. Eds Ihrke et al. Pergamon, New York , pp 391–396. [Google Scholar]
 - Immink, W. F. G. A. , van Toor, A. J. , van der Linde‐Sipman. J. S. & Lubberink, A. A. M. E. (1992) Hyperadrenocorticism in four cats. Veterinary Quarterly 14,81–85. [DOI] [PubMed] [Google Scholar]
 - Johnston, S. D. & Mather, E. C. (1979) Feline plasma Cortisol (hydrocortisone) measured by radioimmunoassay. American Journal of Vetenihin Research 40,190–192. [PubMed] [Google Scholar]
 - Kemppainen. R. J. . Mansfield. P. D. & Sartin. J. L. (1984) Endocrine responses of normal cats to TSH and syn thetic ACTH administration. Journal of the American Animal Hospital Association 20,737–740. [Google Scholar]
 - Medleau, L. , Cowan. L. A. . Cornelius. L. M. & Kemppaine. R. J. (1987) Adrenal function in the cat: the effect of low dose intravenous dexamethasone administration. Research in Veterinary Science 42,260–261. [PubMed] [Google Scholar]
 - Meijer, J. C. Lubberink. A. A. M. E. & Gruys. E. (1978) Cushing's syndrome due to adrenocortical adenoma in a cat. Tijdschift Diergeneeskunde 103 1048–1051. [PubMed] [Google Scholar]
 - Moore. G. E. . Mahaffey, E. A. & Hoenig. M. (1992) Hematologic and serum biochemical effects of long term administration of anti‐inflammatory doses of pred nisone in dogs. American Journal of Veterinary Research 53 1033–1037. [PubMed] [Google Scholar]
 - Myers, N. C. & Bruyette. D. S. (1994a) Feline adreno cortical diseases. Part I: hyperadrenocorticis. Seminars in Veterinary Medicine and Surgery (Small Animal) 9 137–143. [PubMed] [Google Scholar]
 - Myers. N. C. & Bruyette. D. S. (1994b) Feline adreno cortical diseases. Part II: hypoadrenocorticis. Seminars in Veterinary Medicine and Surgery (Small Animal) 9 144–147. [PubMed] [Google Scholar]
 - Nelson. R. W. . Feldman. E. C. & Smith, M. C. (1988. Hyperadrenocorticism in cats: seven cases (1978 1987). Journal of the American Veterinary Medical Association 193 245–250. [PubMed] [Google Scholar]
 - Peterson, M. E. & Kintzer. P. P. (1997) Medical treatment of pituitary‐dependent hyperadrenocorticism ‐ mitotane. Veterinary Clinics of North America: Small Animal Practice 27, 255–272. [DOI] [PubMed] [Google Scholar]
 - Peterson, M. E. . Randolph. J. F. & Mooney. C. T. (1994) Endocrine diseases In: The Cat ‐ Diseases and Clin ical Management. 2nd edn Ed Sherding R. G. Churchill Livingstone; New York , pp 1481–1506. [Google Scholar]
 - Peterson. M. E. & Steele. P. (1986) Pituitary‐dependent hyperadrenocorticism in a cat. Journal of the American Veterinary Medical Association 189,680–683. [PubMed] [Google Scholar]
 - Reusch. C. & Hoyer‐Ott. M. (1995) Zur Bedeutung der Fructosamin‐Bestimmung in der Uberwachung des Diabetes mellitus (II) Untersuchungen bei gesunden und diabetischen Katzen sowie Katzen mit soge nannter Stresshyperglycämie. Kleintierpraxis 40 95. [Google Scholar]
 - Rijnberk. A. & Belshaw, B. E. (1995) o.p'DDD Treatment of canine hyperadrenocorticism: an alternative pro tocol In: Current Veterinary Therapy XI. Eds Kirk R. W. and Bonagura. J. D. W. B. Saunders; Philadel phia . pp 345–349. [Google Scholar]
 - Scon, D. W. . Manning, T. O. & Reimers. T. J. (1982) Iatrogenic Cushing's syndrome in a cat. Feline Practice 30–36.
 - Smith, M. C. & Feldman. E. C. (1987) Plasma endoge nous ACTH concentrations and plasma Cortisol responses to synthetic ACTH and dexamethasone sodium phosphate in healthy cats. American Journal of Veterinary Research 48,1719–1724. [PubMed] [Google Scholar]
 - Swift, G. A. & Brown. R. H. (1976) Surgical treatment of Cushing's syndrome in a cat. Veterinary Record 99, 374–375. [DOI] [PubMed] [Google Scholar]
 - Werner, L. L. Turnwald. G. H. & Barta, O. (1989) Immunologic and Plasma Protein Disorders In Small Animal Clinical Diagnosis by Laboratory Meth ods, 2nd edn Eds Willard M. D. Tvedten H. and Turnwald. G H. W. B. Saunders; Philadelphia , pp 253–272. [Google Scholar]
 - Zerbe. C. A. (1989) Feline hyperadrenocorticism In Current Veterinary Therapy X. Ed Kirk R. W. W. B Saunders; Philadelphia , pp 1038–1042. [Google Scholar]
 - Zerbe. C. A. . Nachreiner. R. F. , Dunstan. R. W. & Daild. J. B. (1987) Hyperadrenocorticism in a cat. Journal of the American Veterinary Medical Association 190 559–562. [PubMed] [Google Scholar]
 
