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. 2008 Feb 5;12(6):415–423. doi: 10.1111/j.1939-1676.1998.tb02144.x

Diagnostic Features of Clinical Neurologic Feline Infectious Peritonitis

Janet E Foley 1,✉, Jean‐Martin Lapointe 2, Philip Koblik 3, Amy Poland 1, Niels C Pedersen 1
PMCID: PMC7167019  PMID: 9857333

Abstract

Feline infectious peritonitis (FIP) is a fatal Arthus‐type immune response of cats to infection with FIP virus, a mutant of the ubiquitous feline enteric coronavirus (FECV). The disease may occur systemically or in any single organ system, and primary neurologic disease is a common subset of such manifestations. We examined 16 domestic cats with clinical neurologic FIP and 8 control cats with nonneurologic FIP, with the intention of identifying the ante‐and postmortem diagnostic tests that most contribute to accurate diagnosis. Of the 16 cats with neurologic FIP, 15 were less than 2 years of age and all 16 originated from large multiplecat households. The most useful antemortem indicators of disease were positive anti‐coronavirus IgG titer in cerebrospinal fluid, high serum total protein concentration, and findings on magnetic resonance imaging suggesting periventricular contrast enhancement, ventricular dilatation, and hydrocephalus. Postmortem diagnosis was facilitated by FIP monoclonal antibody staining of affected tissue and coronavirus‐specific polymerase chain reaction. Most cats with neurologic and ocular forms of FIP had patchy, focal lesions, suggesting that recently developed technologies described in this report may be useful for evaluation of cats with suspected FIP.

Keywords: Magnetic resonance imaging, Polymerase chain reaction

References

  • 1. Foley JE, Poland A., Carlson J., et al. Risk factors for feline infectious peritonitis among cats in multiple‐cat environments with endemic feline enteric coronavirus. J Am Vet Med Assoc 1997;210:1313–1318. [PubMed] [Google Scholar]
  • 2. Poland A., Vennema H., Foley JE, et al. Feline infectious peritonitis is caused by simple mutants of feline enteric coronavirus (FECV) that arise frequently during the course of primary FECV infection. J Clin Microbiol 1996;34:3180–3184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3. Vennema H., Poland A., Hawkins KF, et al. A comparison of the genomes of FECVs and FIPVs and what they tell us about the relationships between feline coronaviruses and their evolution. Feline Pract 1995;23:40–46. [Google Scholar]
  • 4. Vennema H., Poland A., Foley J., et al. Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses. Virology 1998;243:150–157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5. Foley J., Pedersen N. The inheritance of susceptibility to feline infectious peritonitis in purebred catteries. Feline Pract 1996;24:14–22. [Google Scholar]
  • 6. Pedersen NC, Black JW, Boyle JF, et al. Pathogenic differences between various feline coronavirus isolates. Adv Exp Med Biol 1983;173:365–380. [DOI] [PubMed] [Google Scholar]
  • 7. Pedersen N. Feline Infectious Diseases. Goleta , CA : American Veterinary Publisher: 1988. [Google Scholar]
  • 8. Fenner W. Inflammations of the nervous system In: August J., ed. Consultations in Feline Internal Medicine. Philadelphia , PA : WB Saunders: 1991:507–517. [Google Scholar]
  • 9. Kornegay J. Feline infectious peritonitis: The central nervous system form. J Am Anim Hosp Assoc 1978;14:580–584. [Google Scholar]
  • 10. Pedersen NC. An overview of feline enteric coronavirus and infectious peritonitis virus infections. Feline Pract 1995;23:7–22. [Google Scholar]
  • 11. Pedersen NC. Serologic studies of naturally occurring feline infectious peritonitis. Am J Vet Res 1976;37:1449–1453. [PubMed] [Google Scholar]
  • 12. Hickman A., Morris J., Rogers Q., et al. Elimination of feline coronavirus from a large experimental specific‐pathogen‐free cat breeding colony by serologic testing and isolation. Feline Pract 1995;23:96–102. [Google Scholar]
  • 13. Rohrer C., Suter P., Lutz H. Die Diagnositik der felinen infektioesen Peritonitis (FIP): Retrospektive und prospektive Untersuchungen. Kleintierpraxis 1993;38:379–389. [Google Scholar]
  • 14. Peaston A., Higgins R., Naydan D., et al. Evaluation of commercially available antibodies to cytokeratin, intermediate filaments and laminin in normal cat pinna. J Vet Diagn Invest 1992;4:306–311. [DOI] [PubMed] [Google Scholar]
  • 15. Cheung RC, Matsui SM, Greenberg HB. Rapid and sensitive method for detection of hepatitis C virus RNA by using silica particles. J Clin Microbiol 1994;32:2593–2597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16. Foley JE, Poland A., Carlson J., et al. Patterns of feline coronavirus infection and fecal shedding from cats in multiple‐cat environments. J Am Vet Med Assoc 1997;210:1307–1312. [PubMed] [Google Scholar]
  • 17. Greene C. Clinical Microbiology and Infectious Diseases of the Dog and Cat. Philadelphia , PA : WB Saunders; 1985. [Google Scholar]
  • 18. August J. Feline infectious peritonitis: An immune‐mediated coronaviral vasculitis. Vet Clin North Am Small Anim Pract 1984;14:971–984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19. Pedersen N. Feline infectious peritonitis and feline enteric coronavirus infections. Part 2: Feline infectious peritonitis. Feline Prac 1983; 13: 5–19. [Google Scholar]
  • 20. Greene CE, McDermott M., Jameson PH, et al. Bartonella hen selae infection in cats: Evaluation during primary infection, treatment and rechallenge infection. J Clin Microbiol 1996;34:1682–1685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21. Tamke P., Petersen M., Dietze A., et al. Acquired hydrocephalu: and hydromyelia in a cat with feline infectious peritonitis: A case report and brief review. J Can Vet 1988;29:997–1000. [PMC free article] [PubMed] [Google Scholar]
  • 22. Slauson D., Finn J. Meningoencephalitis and panophthalmitis in feline infectious peritonitis. J Am Vet Med Assoc 1972;160:729–734. [PubMed] [Google Scholar]
  • 23. Krum S., Johnson K., Wilson J. Hydrocephalus associated with the noneffusive form of feline infectious peritonitis. J Am Vet Med Assoc 1975;167:746–748. [PubMed] [Google Scholar]
  • 24. Legendre A., Whitenack D. Feline infectious peritonitis with spinal cord involvement in two cats. J Am Vet Med Assoc 1975;160:729–734. [PubMed] [Google Scholar]
  • 25. Summers B., Cummings J., de Lahunta A. Feline infectious peritonitis In: Veterinary Neuropathology. St. Louis , MO : Mosby Year‐Book; 1995:119–121. [Google Scholar]
  • 26. Pedersen N. The history and interpretation of feline coronavirus serology. Feline Pract 1995;23:46–52. [Google Scholar]
  • 27. Wesseling J., Vennema H., Godeke GJ, et al. Nucleotide sequence and expression of the spike (S) gene of canine coronavirus and comparison with the S proteins of feline and porcine coronaviruses. J Gen Virol 1994;75:1789–1794. [DOI] [PubMed] [Google Scholar]
  • 28. Olsen C. A review of feline infectious peritonitis virus: Molecular biology, immunopathogenesis, clinical aspects, and vaccination. Vet Microbiol 1993;36:1–37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29. Pedersen NC, Evermann JF, McKiernan AJ, et al. Pathogenicity studies of feline coronavirus isolates 79–1146 and 79–1683. Am J Vet Res 1984;45:2580–2585. [PubMed] [Google Scholar]
  • 30. Stoddart C., Scott F. Intrinsic resistance of feline peritoneal macrophages to coronaviruses correlates with virulence. J Virol 1989;63:436–440. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 31. Tammer R., Evensen O., Lutz H., et al. Immunohistological demonstration of feline infectious peritonitis virus antigen in paraffin‐embedded tissues using feline ascites or murine monoclonal antibodies. Vet Immunol Immunopathol 1995;49:117–182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 32. Fox J., Brink N., Zuckerman N. Detection of herpesvirus DNA by nested polymerase chain reaction in cerebrospinal fluid of human immunodeficiency virus‐infected persons with neurologic disease: A prospective evaluation. Infect Dis 1995;172:1087–1090. [DOI] [PubMed] [Google Scholar]
  • 33. Boerman R., Arnoldus E., Raap A. Polymerase chain reaction and viral culture techniques to detect HSV in small volumes of cerebrospinal fluid. An experimental mouse encephalitis study. Virol Methods 1989; 25: 189–198. [DOI] [PubMed] [Google Scholar]
  • 34. Houtman J., Fleming J. Dissociation of demyelination and viral clearance in congenitally immunodeficient mice infected with murine coronavirus JHM. Neurovirology 1996;2:101–110. [DOI] [PubMed] [Google Scholar]
  • 35. Hurtrel M. Comparison of early and late feline immunodeficiency virus encephalopathies. AIDS 1992;6:399–406. [DOI] [PubMed] [Google Scholar]
  • 36. Innes J., Saunders L. Comparative Neuropathology. New York . NY : Academic Press; 1962. [Google Scholar]
  • 37. Fankhauser R., Fatzer R., Steck F., et al. Morbus Aujesky bei hund und katze in der Schweiz. Schweiz Arch Tierheilkd 1975;117:623–629. [PubMed] [Google Scholar]
  • 38. Appel M., Sheffy B., Percy D., et al. Canine distemper virus in domesticated cats and pigs. Am J Vet Res 1974;35:803–806. [PubMed] [Google Scholar]
  • 39. Dubey J., Beattie C. Toxoplasmosis of Animals and Man. Boca Raton , FL : CRC Press; 1988. [Google Scholar]
  • 40. Cook R., Wilcox G. A paramyxovirus‐like agent associated with demyelinating lesions in the CNS of cats. Proc Am Assoc Neuropathol 1981:89.
  • 41. Lundgren AI, Ludwig H. Clinically diseased cats with non‐suppurative meningoencephalomyelitis have borna disease virus‐specific antibodies. Acta Vet Scand 1993;34:101–103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 42. Nowotny N., Weissenbock H. Description of feline nonsuppurative meningoencephalomyelitis (“staggering disease”) and studies of its etiology. J Clin Microbiol 1995;33:1668–1669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 43. Dubey J. A review of Neospora caninum and Neospora‐like infections in animals. J Protozool Res 1992;2:40–52. [Google Scholar]
  • 44. Dubey J., Higgins R., Barr B., et al. Sarcocystis‐associated meningoencephalomyelitis in a cat. J Vet Diagn Invest 1994;6:1118–1120. [DOI] [PubMed] [Google Scholar]
  • 45. Gruffydd‐Jones T., Galloway P., Pearson G. Feline spongiform encephalopathy. J Small Anim Pract 1991;33:471–476. [Google Scholar]

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