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. 2005 Feb 4;8(1):41–78. doi: 10.1002/jemt.1060080105

Viral infections in the acquired immunodeficiency syndrome

Sara E Miller 1,✉, David N Howell 2
PMCID: PMC7167188  PMID: 2854554

Abstract

The following communication is a tripartite synopsis of the role of viral infection in the acquired immunodeficiency syndrome (AIDS). The first section describes the impact of viral opportunistic infection in AIDS; for each virus, clinical presentation and diagnosis, laboratory diagnostic approaches (with emphasis on electron microscopy), and therapeutic interventions attempted to date are discussed. The second segment explores current theories on the pathogenesis of AIDS, and describes diagnostic and therapeutic approaches to the syndrome itself. The final section catalogues ultrastructural anomalies in the cells of AIDS patients, many of which have been mistakenly identified as etiologic agents.

Keywords: Viral diagnosis/detection, Electron microscopy/light microscopy, Antiviral therapy

References

  1. Agha, F. P. , Nostrant, T. T. , Abrams, G. D. , Mazanec, M. , Van Moll, L. , and Gumucio, J. J. (1986) Cytomegalovirus cholangitis in a homosexual man with acquired immune deficiency syndrome. Am. J. Gastroenterol., 81: 1068–1072. [PubMed] [Google Scholar]
  2. Almeida, J. D. (1980) Practical aspects of diagnostic electron microscopy. Yale J. Biol. Med., 53: 5–18. [PMC free article] [PubMed] [Google Scholar]
  3. Almeida, J. D. , Howatson, A. F. , and Williams, M. G. (1962) Electron microscopic study of human warts; sites of production and nature of inclusion bodies. J. Invest. Dermatol., 38: 337–345. [PubMed] [Google Scholar]
  4. Anderson, N. , and Doane, F. W. (1972) Agar diffusion method for negative staining of microbial suspensions in salt solutions. Appl. Environ. Microbiol., 24: 495–496. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Anderson, N. , and Doane, F. W. (1973) Specific identification of enteroviruses by immuno‐electron microscopy using serum‐in‐agar diffusion method. Can. J. Microbiol., 19: 585–589. [DOI] [PubMed] [Google Scholar]
  6. Anderson, M. J. , Kidd, I. M. , Jones, S. E. , Pattison, J. R. , Grieco, M. H. , Lange, M. , Buimovici‐Klein, E. , and Cooper, L. Z. (1985) Parvovirus infection and the acquired immunodeficiency syndrome ‘letter’. Ann. Intern. Med., 102: 275. [DOI] [PubMed] [Google Scholar]
  7. Andersson, J. , Sköldenberg, B. , Henle, W. , Giesecke, J. , Örtqvist, A. , Julander, I. , Gustavsson, E. , Akerlund, B. , Britton, S. , and Ernberg, I. (1987) Acyclovir treatment in infectious mononucleosis: a clinical and virological study. Infection, 15(Supp.): S14–S20. [DOI] [PubMed] [Google Scholar]
  8. Andiman, W. A. , Eastman, R. , Martin, K. , Katz, B. Z. , Rubinstein, A. , Pitt, J. , Pahwa, S. , and Miller, G. (1985) Opportunistic lymphoproliferations associated with Epstein‐Barr viral DNA in infants and children with AIDS. Lancet, 2: 1390–1393. [DOI] [PubMed] [Google Scholar]
  9. Andiman, W. , Gradoville, L. , Heston, L. , Neydorff, R. , Savage, M. E. , Kitchingman, G. , Shedd, D. , and Miller, G. (1983) Use of cloned probes to detect Epstein‐Barr viral DNA in tissues of patients with neoplastic and lymphoproliferative diseases. J. Infect. Dis., 148: 967–977. [DOI] [PubMed] [Google Scholar]
  10. Andrews, C. A. , Daniel, R. W. , and Shah, K. V. (1983) Serologic studies of papovavirus infections in pregnant women and renal transplant recipients In Sever J. L. and Madden D. L. (eds.): Polyomaviruses and Human Neurological Diseases. New York: Alan R. Liss, Inc., pp. 133–141. [PubMed] [Google Scholar]
  11. Armstrong, D. , Gold, J. W. , Dryjanski, J. , Whimbey, E. , Polsky, B. , Hawkins, C. , Brown, A. E. , Bernard, E. , and Kiehn, T. E. (1985) Treatment of infections in patients with the acquired immunodeficiency syndrome. Ann. Intern. Med., 103: 738–743. [DOI] [PubMed] [Google Scholar]
  12. Åsjö, B. , Morfeldt‐Månson, L. , Albert, J. , Biberfeld, G. , Karlsson, A. , Lindman, K. , and Fenyö, E. M. (1986) Replicative capacity of human immunodeficiency virus from patients with varying severity of HIV infection. Lancet, 2: 660–662. [PubMed] [Google Scholar]
  13. Bach, M. C. (1986) Breakthrough of cytomegalovirus infection despite 9‐(1,3‐dihydroxy‐2‐propoxymethyl)guanine therapy ‘letter’. Ann. Intern. Med., 104: 587. [DOI] [PubMed] [Google Scholar]
  14. Balthazar, E. J. , Megibow, A. J. , Fazzini, E. , Opulencia, J. F. , and Engel, I. (1985) Cytomegalovirus colitis in AIDS: Radiographic findings in 11 patients. Radiology, 155: 585–589. [DOI] [PubMed] [Google Scholar]
  15. Banks, L. , Spence, P. , Androphy, E. , Hubbert, N. , Matlashewski, G. , Murray, A. , and Crawford, L. (1987) Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas. J. Gen. Virol., 68: 1351–1359. [DOI] [PubMed] [Google Scholar]
  16. Barbour, S. D. (1987) Acquired immunodeficiency syndrome of childhood. Pediatr. Clin. North Am., 34: 247–268. [DOI] [PubMed] [Google Scholar]
  17. Barr, A. , and Mitchell, R. (1987) Enhanced enzyme immunoassay for the detection of hepatitis B surface antigen. Lancet, 2: 912–913. [DOI] [PubMed] [Google Scholar]
  18. Barin, F. , M'Boup, S. , Denis, F. , Kanki, P. , Allan, J. S. , Lee, T. H. , and Essex, M. (1985) Serological evidence for virus related to simian T‐lymphotropic retrovirus III in residents of West Africa. Lancet, 2: 1387–1389. [DOI] [PubMed] [Google Scholar]
  19. Barrio, J. L. , Harcup, C. , Baier, H. J. , and Pitchenik, A. E. (1987) Value of repeat fiberoptic bronchoscopies and significance of nondiagnostic bronchoscopic results in patients with the acquired immunodeficiency syndrome. Am. Rev. Respir. Dis., 135: 422–425. [DOI] [PubMed] [Google Scholar]
  20. Becker, W. B. , McIntosh, K. , Dees, J. H. , and Chanock, R. M. (1967) Morphogenesis of avian infectious bronchitis virus and a related human virus (strain 229E). J. Virol., 1: 1019–1027. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Beckman, A. M. , and Shah, K. V. (1983) Propagation and primary isolation of JCV and BKV in urinary epithelial cell cultures In Sever J. L. and Madden D. L. (eds.): Polyomaviruses and Human Neurological Disease. New York: Alan R. Liss, Inc., pp. 3–14. [PubMed] [Google Scholar]
  22. Berger, J. R. (1987) Neurological complications of human immunodeficiency virus infection. Postgrad. Med., 81 (1): 72–79. [DOI] [PubMed] [Google Scholar]
  23. Berman, M. , Minowada, J. , Loew, J. M. , Ramsey, M. M. , Ebie, N. , and Knospe, W. H. (1985) Burkitt cell acute lymphoblastic leukemia with partial expression of T‐cell markers and subclonal chromosome abnormalities in a man with acquired immunodeficiency syndrome. Cancer Genet. Cytogenet., 16: 341–347. [DOI] [PubMed] [Google Scholar]
  24. Birx, D. L. , Redfield, R. R. , and Tosato, G. (1986) Defective regulation of Epstein‐Barr virus infection in patients with acquired immunodeficiency syndrome (AIDS) or AIDS‐related disorders. N. Engl. J. Med., 314: 874–879. [DOI] [PubMed] [Google Scholar]
  25. Blaser, M. J. , and Cohn, D. L. (1986) Opportunistic infections in patients with AIDS: Clues to the epidemiology of AIDS and the relative virulence of pathogens. Rev. Infect. Dis., 8: 21–30. [DOI] [PubMed] [Google Scholar]
  26. Bleiweiss, I. J. , Pervez, N. K. , Hammer, G. S. , and Dikman, S. H. (1986) Cytomegalovirus‐induced adrenal insufficiency and associated renal cell carcinoma in AIDS. Mt. Sinai J. Med. (NY), 53: 676–679. [PubMed] [Google Scholar]
  27. Blumenfeld, W. , Wagar, E. , and Hadley, W. K. (1984) Use of the transbronchial biopsy for diagnosis of opportunistic pulmonary infections in acquired immunodeficiency syndrome (AIDS). Am. J. Clin. Pathol., 81: 1–5. [DOI] [PubMed] [Google Scholar]
  28. Boldogh, L. , Beth, E. , Huang, E. S. , Kyalwazi, S. K. , and Giraldo, G. (1981) Kaposi's sarcoma. IV. Detection of CMV DNA, CMV RNA and CMNA in tumor biopsies. Int. J. Cancer, 28: 469–474. [DOI] [PubMed] [Google Scholar]
  29. Bolognesi, D. P. , and Fishinger, P. J. (1985) Prospects for treatment of human retrovirus‐associated diseases. Cancer Res. ‘Suppl.’, 45: 4700S–4705S. [PubMed] [Google Scholar]
  30. Borkowsky, W. , Krasinski, K. , Paul, D. , Moore, T. , Bebenroth, D. , and Chandwani, S. (1987) Human‐immunodeficiency‐virus infections in infants negative for anti‐HIV by enzyme‐linked immunoassay. Lancet, 1: 1168–1170. [DOI] [PubMed] [Google Scholar]
  31. Brandsma, J. , and Miller, G. (1980) Nucleic acid spot hybridization: Rapid quantitative screening of lymphoid cell lines for Epstein‐Barr viral DNA. Proc. Natl. Acad. Sci. U.S.A., 77: 6851–6856. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Britton, C. B. , Mesa‐Tejada, R. , Fenoglio, C. M. , Hays, A. P. , Garvey, G. G. , and Miller, J. R. (1985) A new complication of AIDS: Thoracic myelitis caused by herpes simplex virus. Neurology, 35: 1071–1074. [DOI] [PubMed] [Google Scholar]
  33. Brooks, B. R. , and Walker, D. L. (1984) Progressive multifocal leukoencephalopathy. Neurol. Clin., 2: 299–313. [PubMed] [Google Scholar]
  34. Brown, M. S. , Anderson, R. G. W. , and Goldstein, J. L. (1983) Recycling receptors: The round‐trip itinerary of migrant membrane proteins. Cell, 32: 663–667. [DOI] [PubMed] [Google Scholar]
  35. Budka, H. , and Shah, K. V. (1983) Papovavirus antigens in paraffin sections of PML brains In Sever J. L. and Madden D. L. (eds.): Polyomaviruses and Human Neurological Disease. New York: Alan R. Liss, Inc., pp. 299–309. [PubMed] [Google Scholar]
  36. Burrage, T. G. , Andiman, W. A. , Katz, B. Z. , and Miller, G. (1984) Virus‐like rods in a lymphoid line from an infant with AIDS ‘letter’. N. Engl. J. Med., 310: 1460–1461. [DOI] [PubMed] [Google Scholar]
  37. Carter, W. A. , Strayer, D. R. , Brodsky, I. , Lewin, M. , Pellegrino, M. G. , Einck, L. , Henriques, H. F. , Simon, G. L. , Parenti, D. M. , Scheib, R. G. , Schulof, R. S. , Montefiori, D. C. , Robinson, W. E. , Mitchell, W. M. , Volsky, D. J. , Paul, D. , Paxton, H. , Meyer, W. A., III , Karikó, K. , Reichenbach, N. , Suhadolnik, R. J. , and Gilespie, D. H. (1987) Clinical, immunological, and virological effects of ampligen, a mismatched double‐stranded RNA, in patients with AIDS or AIDS‐related complex. Lancet, 1: 1286–1292. [DOI] [PubMed] [Google Scholar]
  38. Casareale, D. , Dewhurst, S. , Sonnabend, J. , Sinagil, F. , Purtilo, D. , and Volsky, D. J. (1984–1985) Prevalence of AIDS‐associated retrovirus and antibodies among male homosexuals at risk for AIDS in Greenwich Village. AIDS Res., 1: 407–421. [DOI] [PubMed] [Google Scholar]
  39. Catovsky, D. , Greaves, M. F. , Rose, M. , Galton, D. A. G. , Goolden, A. W. G. , McCluskey, D. R. , White, J. M. , Lampert, I. , Bourikas, G. , Ireland, R. , Brownell, A. I. , Bridges, J. M. , Blattner, W. A. , and Gallo, R. C. (1982) Adult T‐cell lymphoma‐leukaemia in blacks from the West Indies. Lancet, 1: 639–643. [DOI] [PubMed] [Google Scholar]
  40. Centers for Disease Control (1987) Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. M.M.W.R. 36 (Suppl. 1S): 3S–15S. [PubMed] [Google Scholar]
  41. Chandler, F. W. , White, E. H. , Callaway, C. S. , Spira, T. J. , and Ewing, E. P., Jr. , (1984) Unidentified virus‐like particles in the intestine of patients with the acquired immunodeficiency syndrome. Ann. Intern. Med., 100: 851–853. [DOI] [PubMed] [Google Scholar]
  42. Chang, C. M. , Woo, E. , Yu, Y. L. , Huang, C. Y. , and Din, D. (1987) Herpes zoster and its neurological complications. Postgrad. Med. J., 63: 85–89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Chany, E. , Moscovici, O. , Lebon, P. , and Rousset, S. (1982) Association of coronavirus infection with necrotizing enterocolitis. Pediatrics, 69: 209–214. [PubMed] [Google Scholar]
  44. Chase, R. A. , Pottage, J. C. , Haber, M. H. , Kistler, G. , Jensen, D. , and Levin, S. (1987) Herpes simplex viral hepatitis in adults: Two case reports and review of the literature. Rev. Infect. Dis., 9: 329–333. [DOI] [PubMed] [Google Scholar]
  45. Chesters, P. M. , Heritage, J. , and McCance, D. J. (1983) Persistence of DNA sequences of BK virus and JC virus in normal tissues and diseased tissues. Infect. Dis., 147: 676–684. [DOI] [PubMed] [Google Scholar]
  46. Chou, S. , and Merigan, T. C. (1983) Rapid detection and quantitation of human cytomegalovirus in urine through DNA hybridization. N. Engl. J. Med., 308: 921–925. [DOI] [PubMed] [Google Scholar]
  47. Ciobanu, N. , and Wiernik, P. H. (1986) Malignant lymphomas, AIDS, and the pathogenetic role of Epstein‐Barr virus. Mt. Sinai J. Med. (NY), 53: 627–638. [PubMed] [Google Scholar]
  48. Coffin, J. M. , (1986) Genetic variation in AIDS viruses. Cell, 46: 1–4. [DOI] [PubMed] [Google Scholar]
  49. Cole, E. L. , Meisler, D. M. , Calabrese, L. H. , Holland, G. N. , Mondino, B. J. , and Conant, M. A. (1984) Herpes zoster ophthalmicus and acquired immune deficiency syndrome. Arch. Ophthalmol., 102: 1027–1029. [DOI] [PubMed] [Google Scholar]
  50. Coleman, D. V. , Gardner, S. D. , Mulholland, C. , Fridiksdottir, V. , Porter, A. A. , Lilford, R. , and Valdimarsson, H. (1983) Human polyomaviruses in pregnancy. A model for the study of defence mechanisms to virus reactivation. Clin. Exp. Immunol., 53: 289–296. [PMC free article] [PubMed] [Google Scholar]
  51. Coleman, D. V. , Mackenzie, S. D. , Gardner, S. D. , Poulding, J. M. , Amer, B. , and Russell, W. J. I. (1978) Human polyomavirus (BK) infection and ureteric stenosis in renal allograft recipients. J. Clin. Pathol., 31: 338–347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Collaborative DHPG Treatment Study Group (1986) Treatment of serious cytomegalovirus infections with 9‐(1,3‐dihydroxy‐2‐propoxymethyl)guanine in patients with AIDS and other immunodeficiencies. N. Engl. J. Med., 314: 801–805. [DOI] [PubMed] [Google Scholar]
  53. Cone, L. A. , and Schiffman, M. A. (1984) Herpes zoster and the acquired immunodeficiency syndrome ‘letter’. Ann. Intern. Med., 100: 462. [DOI] [PubMed] [Google Scholar]
  54. Croxson, T. , Chabon, A. B. , Rorat, E. , and Barash, I. M. (1984) Intraepithelial carcinoma of the anus in homosexual men. Dis. Colon Rectum, 27: 325–330. [DOI] [PubMed] [Google Scholar]
  55. De Clercq, E. (1986) Current leads in antiviral chemotherapy. J. Antimicrob. Chemother., 17: 399–402. [DOI] [PubMed] [Google Scholar]
  56. De Jong, P. J. , Valderrama, G. , Spigland, I. , and Horwitz, M. S. (1983) Adenovirus isolates from the urine of patients with acquired immunodeficiency syndrome. Lancet, 1: 1293–1296. [DOI] [PubMed] [Google Scholar]
  57. De la Monte, S. M. , Ho, D. D. , Schooley, R. T. , Hirsch, M. S. , and Richardson, E. P. (1987) Subacute encephalomyelitis of AIDS and its relation to HTLV‐III infection. Neurology, 37: 562–569. [DOI] [PubMed] [Google Scholar]
  58. De Venecia, G. , Zu Rhein, G. M. , Pratt, M. V. , and Kisken, W. (1971) Cytomegalic inclusion retinitis in an adult. Arch. Ophthalmol., 86: 44–57. [DOI] [PubMed] [Google Scholar]
  59. Doane, F. W. , and Anderson, N. (1987) Electron Microscopy in Diagnostic Virology. New York: Cambridge University Press. [Google Scholar]
  60. Doerr, H. W. , Braun, R. , and Munk, K. (1985) Human cytomegalovirus infection: Recent developments in diagnosis and epidemiology: Klin. Wochenschr, 63: 241–251. [DOI] [PubMed] [Google Scholar]
  61. Doerr, H. W. , Lehmair, H. , Schmitz, H. , Kampa, D. , and Luthardt, T. (1977) Simple mathematical deductions in the seroepidemiology of viral infections. I. Herpesvirus group (herpes virus hominis, varicella‐zoster‐virus, cytomegalovirus, Epstein‐Barr‐virus). Zentralbl. Bakteriol. Mikrobiol. Hyg. ‘A’, 238: 149–164. [PubMed] [Google Scholar]
  62. Doerr, H. W. , Rentschler, M. , and Scheifler, G. (1987) Serologic detection of active infections with herpes viruses (CMV, EBV, HSV, VZV): Diagnostic potential of IgA class and IgG sub‐class‐specific antibodies. Infection, 15: 93–98. [DOI] [PubMed] [Google Scholar]
  63. Dotz, W. I. , and Berman, B. (1983) Kaposi's sarcoma, chronic ulcerative herpes simplex, and acquired immunodeficiency. Arch. Dermatol., 119: 93–94. [PubMed] [Google Scholar]
  64. Drew, W. L. (1986) Is cytomegalovirus a cofactor in the pathogenesis of AIDS and Kaposi's sarcoma? Mt. Sinai J. Med. (NY), 53: 622–626. [PubMed] [Google Scholar]
  65. Drew, W. L. , Mintz, L. , Miner, R. C. , Sando, M. , and Ketterer, B. (1981) Prevalence of cytomegalovirus infection in homosexual men. J. Infect. Dis., 143: 188–192. [DOI] [PubMed] [Google Scholar]
  66. Duchowny, M. , Caplan, L. , and Silber, G. (1979) Cytomegalovirus infection of the adult nervous system. Ann. Neurol., 5: 458–461. [DOI] [PubMed] [Google Scholar]
  67. Edwards, D. D. (1987) New virus, growth factor found for AIDS. Sci. News, 131: 156. [Google Scholar]
  68. Edwards, R. H. , Messing, R. , and McKendall, R. R. (1985) Cytomegalovirus meningoencephalitis in a homosexual man with Kaposi's sarcoma: Isolation of CMV from CSF cells. Neurology, 35: 560–562. [DOI] [PubMed] [Google Scholar]
  69. Elfassi, E. , Romet‐Lemonne, J.‐L. , Essex, M. , Frances‐McLane, M. , and Haseltine, W. A. (1984) Evidence of extrachromosomal forms of hepatitis B viral DNA in a bone marrow culture obtained from a patient recently infected with hepatitis B virus. Proc. Natl. Acad. Sci. U.S.A., 81: 3526–3528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. El‐Mekki, A. , Al‐Nakib, W. , and Bibi, R. (1987) Factors affecting the detection of cytomegalovirus in urine by sandwich enzyme immunoassays. J. Virol. Methods, 15: 75–83. [DOI] [PubMed] [Google Scholar]
  71. Elta, G. , Turnage, R. , Eckhauser, F. E. , Agha, F. , and Ross, S. (1986) A submucosal antral mass caused by cytomegalovirus infection in a patient with acquired immunodeficiency syndrome. Am. J. Gastroenterol., 81: 714–717. [PubMed] [Google Scholar]
  72. Emanuel, D. , Peppard, J. , Stover, D. , Gold, J. , Armstrong, D. , and Hammerling, U. (1986) Rapid immunodiagnosis of cytomegalovirus pneumonia by bronchoalveolar lavage using human and murine monoclonal antibodies. Ann. Intern. Med., 104: 476–481. [DOI] [PubMed] [Google Scholar]
  73. Engler, J. A. , and Kilpatrick, B. A. (1981) Cloning and characterization of class B adenoviruses Ad 3 and Ad 7 DNA. Gene, 13: 125–132. [DOI] [PubMed] [Google Scholar]
  74. Epstein, M. A. , and Achong, B. G. (1977) Recent progress in Epstein‐Barr virus research. Annu. Rev. Microbiol., 31: 421–445. [DOI] [PubMed] [Google Scholar]
  75. Epstein, M. A. , and Achong, B. G. (1979) Morphology of the virus and of virus‐induced cytopathologic change In Epstein M. A. and Achong B. G. (eds.): The Epstein‐Barr Virus. New York: Springer‐Verlag, pp. 23–27. [Google Scholar]
  76. Epstein, L. G. , Sharer, L. R. , Cho, E.‐S. , Myenhofer, M. , Navia, B. A. , and Price, R. W. (1984–1985) HTLV‐III/LAV‐like retrovirus particles in the brains of patients with AIDS encephalopathy. AIDS Res., 1: 447–454. [DOI] [PubMed] [Google Scholar]
  77. Ewing, E. P., Jr. , Spira, T. J. , and Chandler, F. W. (1983) Unusual cytoplasmic body in lymphoid cells of homosexual men with unexplained lymphadenopathy. A preliminary report. N. Engl. J. Med., 308: 819–822. [DOI] [PubMed] [Google Scholar]
  78. Fackler, J. C. , Nagel, J. E. , Adler, W. H. , Mildvan, P. T. , and Ambinder, R. F. (1985) Epstein‐Barr virus infection in a child with acquired immunodeficiency syndrome. Am. J. Dis. Child., 139: 1000–1004. [DOI] [PubMed] [Google Scholar]
  79. FDA (1985) Progress on AIDS. FDA Drug Bull., 15: 27–32. [PubMed] [Google Scholar]
  80. Fenoglio, C. M. , Oster, M. W. , Lo Gerfo, P. , Reynolds, T. , Edelson, R. , Patterson, J. A. K. , Madeiros, E. , and McDougall, J. K. (1982) Kaposi's sarcoma following chemotherapy for testicular cancer in a homosexual man: Demonstration of cytomegalovirus RNA in sarcoma cells. Hum. Pathol., 13: 955–959. [DOI] [PubMed] [Google Scholar]
  81. Feremans, W. , Menu, R. , Dustin, P. , Clumeck, N. , Marcelis, L. , and Hupin, J. (1983) Virus‐like particles in lymphocytes of seven cases of AIDS in black Africans. Lancet, 2: 52–53. [DOI] [PubMed] [Google Scholar]
  82. Feremans, W. W. , Menu, R. , Goldman, M. , Schandene, L. , Portetelle, D. , Cleuter, Y. , Flament, J. , Dustin, P. , Wybran, J. , and Burny, A. (1984) Ultrastructural demonstration of retrovirus antigens with immuno‐gold staining in prodromal acquired immune deficiency syndrome. J. Clin. Pathol., 37: 1399–1403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Ferenczy, A. , Matao, M. , Nagai, N. , Silverstein, S. J. , and Crum, C. (1985) Latent papillomavirus and recurring genital warts. N. Engl. J. Med., 313: 784–788. [DOI] [PubMed] [Google Scholar]
  84. Fiddian, A. P. (1987) Prevention of herpes simplex virus infections in susceptible patients. Infection, 15 (Suppl. 1): S21–S25. [DOI] [PubMed] [Google Scholar]
  85. Fong, C. K. Y. , and Hsiung, G. D. (1978) Light and electron microscopy of virus‐infected cells In Seligson D. (ed.): CRC Handbook Series in Clinical Laboratory Science; Section H: Virology and Rickettsiology, Vol. 1, Part 1. West Palm Beach, FL: CRC Press, Inc., pp. 43–108. [Google Scholar]
  86. Frager, D. H. , Frager, J. D. , Wolf, E. L. , Rand, L. G. , St. Onge, G. , Mitsudo, S. , Bodner, L. , Brandt, L. J. , and Beneventano, T. C. (1986) Cytomegalovirus colitis in acquired immune deficiency syndrome: Radiologic spectrum. Gastrointest. Radiol., 11: 241–246. [DOI] [PubMed] [Google Scholar]
  87. Frazer, I. H. , Medley, G. , Crapper, R. M. , Brown, T. C. , and Mackay, I. R. (1986) Association between anorectal dysplasia, human papillomavirus, and human immunodeficiency virus infection in homosexual men. Lancet, 2: 657–660. [DOI] [PubMed] [Google Scholar]
  88. Freedman, P. G. , Weiner, B. C. , and Balthazar, E. J. (1985) Cytomegalovirus esophagogastritis in a patient with acquired immunodeficiency syndrome. Am. J. Gastroenterol., 80: 434–437. [PubMed] [Google Scholar]
  89. Friedman‐Kien, A. E. , Lafleur, F. L. , Gendler, E. , Hennessey, N. P. , Montagna, R. , Halbert, S. , Rubinstein, P. , Krasinski, K. , Zang, E. , and Poiesz, B. (1986) Herpes zoster: A possible early clinical sign for development of acquired immunodeficiency syndrome in high‐risk individuals. J. Am. Acad. Dermatol., 14: 1023–1028. [DOI] [PubMed] [Google Scholar]
  90. Furio, M. M. , and Wordell, C. J. (1985) Treatment of infectious complications of acquired immunodeficiency syndrome. Clin. Pharmacol., 4: 539–554. [PubMed] [Google Scholar]
  91. Gallo, R. C. , Salahuddin, S. Z. , Popovic, M. , Shearer, G. M. , Kaplan, M. , Haynes, B. F. , Palker, T. J. , Redfield, R. , Oleske, J. , Safai, B. , White, G. , Foster, P. , and Markham, P. D. (1984) Frequent detection and isolation of cytoplasmic retroviruses (HTLV‐III) from patients with AIDS. Science, 224: 500–503. [DOI] [PubMed] [Google Scholar]
  92. Gallo, R. C. , Sarngadharan, M. G. , Popovic, M. , Shaw, G. M. , Hahn, B. , Wong‐Staal, F. , Robert‐Guroff, M. , Salahuddin, S. Z. , and Markham, P. D. (1986) HTLV‐III and the etiology of AIDS. Prog. Allergy, 37: 1–45. [PubMed] [Google Scholar]
  93. Galloway, P. G. (1984) Widespread cytomegalovirus infection involving the gastrointestinal tract, biliary tree, and gallbladder in an immunocompromised patient ‘letter’. Gastroenterology, 87: 1407. [PubMed] [Google Scholar]
  94. Gardiner, T. , Kirk, J. , and Dermott, E. (1983) “Virus‐like particles” in lymphocytes in AIDS are normal organelles, not viruses ‘letter’. Lancet, 2: 963–964. [DOI] [PubMed] [Google Scholar]
  95. Gelmann, E. P. , Popovic, M. , Blayney, D. , Masur, H. , Sidhu, G. , Stahl, R. E. , and Gallo, R. C. (1983) Proviral DNA of a retrovirus, human T‐cell leukemia virus, in two patients with AIDS. Science, 220: 862–865. [DOI] [PubMed] [Google Scholar]
  96. Gendelman, H. E. , Phelps, W. , Feigenbaum, L. , Ostrove, J. M. , Adachi, A. , Howley, P. M. , Khoury, G. , Ginsberg, H. S. , and Martin, M. A. (1986) Trans‐activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses. Proc. Natl. Acad. Sci. U.S.A., 83: 9759–9763. [DOI] [PMC free article] [PubMed] [Google Scholar]
  97. Gervais, F. , Tsoukas, C. , Fuks, A. , and Shuster, J. , (1983–1984) Natural history of the AIDS related complex in hemophilia: Relationships to Epstein‐Barr virus. AIDS Res., 1: 197–209. [DOI] [PubMed] [Google Scholar]
  98. Getchell, J. P. , Heath, J. L. , Hicks, D. R. , Sporborg, C. , Mann, J. M. , and McCormick, J. B. (1987) Detection of human T cell leukemia virus type I and human immunodeficiency virus in cultured lymphocytes of a Zairian man with AIDS. J. Infect. Dis., 155: 612–616. [DOI] [PubMed] [Google Scholar]
  99. Ghadially, F. N. (1982) Ultrastructural Pathology of the Cell and Matrix, 2nd Edition London: Butterworth. [Google Scholar]
  100. Gilden, D. H. , Hayward, A. R. , Krupp, J. , Hunter‐Laszlo, M. , Huff, J. C. , and Vafai, A. (1987) Varicella‐zoster virus infection of human mononuclear cells. Virus Res., 7: 117–129. [DOI] [PubMed] [Google Scholar]
  101. Giraldo, G. , and Beth, E. (1986) The involvement of cytomegalovirus in acquired immune deficiency syndrome and Kaposi's sarcoma. Prog. Allergy, 37: 319–331. [DOI] [PubMed] [Google Scholar]
  102. Giraldo, G. , Beth, E. , and Kyalwazi, S. K. (1984) Role of cytomegalovirus in Kaposi's sarcoma. IARC Sci. Publ., 63: 583–606. [PubMed] [Google Scholar]
  103. Gleaves, C. A. , Smith, T. F. , Shuster, E. A. , and Pearson, G. R. (1985) Comparison of standard tube and shell vials culture techniques for the detection of cytomegalovirus in clinical specimens. J. Clin. Microbiol., 21: 217–221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  104. Gold, J. W. (1985) Clinical spectrum of infections in patients with HTLV‐III‐associated diseases. Cancer Res. ‘Suppl.’, 45: 4652S–4654S. [PubMed] [Google Scholar]
  105. Golden, J. A. , Hollander, H. , Stulbarg, M. S. , and Gamsu, G. (1986) Bronchoalveolar lavage as the exclusive diagnostic modality for Pneumocystis carinii pneumonia. A prospective study among patients with acquired immunodeficiency syndrome. Chest, 90: 18–22. [DOI] [PubMed] [Google Scholar]
  106. Goldstein, L. C. , McDougall, J. , Hackman, R. , Meyers, J. D. , Thomas, E. D. , and Nowinski, R. C. (1982) Monoclonal antibodies to cytomegalovirus: Rapid identification of clinical isolates and preliminary use in diagnosis of cytomegalovirus pneumonia. Infect. Immun., 38: 273–281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  107. Gonda, M. A. (1988) Molecular genetics and structure of the human immunodeficiency virus. J. Electron Microsc. Tech., 8: 17–40. [DOI] [PubMed] [Google Scholar]
  108. Gorelkin, L. , Chandler, F. W. , and Ewing, E. P., Jr. , (1986) Staining qualities of cytomegalovirus inclusions in the lungs of patients with the acquired immunodeficiency syndrome: A potential source of diagnostic misinterpretation. Hum. Pathol., 17: 926–929. [DOI] [PubMed] [Google Scholar]
  109. Gotlieb, M. , Schroff, R. , Shanker, H. M. , Weisman, J. D. , Fan, P. T. , Wolf, R. A. , and Saxon, A. (1981) Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. Evidence of a new acquired cellular immunodeficiency. N. Engl. J. Med., 305: 1425–1431. [DOI] [PubMed] [Google Scholar]
  110. Greenspan, D. , Greenspan, J. S. , Conant, M. , Petersen, V. , Silverman, S., Jr. , and de Souza, Y. (1984) Oral “hairy” leukoplakia in male homosexuals: Evidence of association with both papillomavirus and a herpesgroup virus. Lancet, 2: 831–834. [DOI] [PubMed] [Google Scholar]
  111. Greenspan, J. S. , Greenspan, D. , Lennette, E. T. , Abrams, D. I. , Conant, M. A. , Petersen, V. , and Freese, U. K. (1985) Replication of Epstein‐Barr virus within the epithelial cells of oral “hairy” leukoplakia, an AIDS‐associated lesion. N. Engl. J. Med., 313: 1564–1571. [DOI] [PubMed] [Google Scholar]
  112. Greenspan, J. S. , and Shillitoe, E. J. (1984) Microbial pathogenicity in oral soft tissue diseases. J. Dent. Res., 63: 431–434. [DOI] [PubMed] [Google Scholar]
  113. Griffiths, J. B. (1983) Hepatitis B vaccines. Vaccine, 1: 3. [DOI] [PubMed] [Google Scholar]
  114. Griffiths, P. D. (1985) Rapid diagnosis of cytomegalovirus infection. J. Hosp. Infect., 6 (Suppl. C): 35–41. [DOI] [PubMed] [Google Scholar]
  115. Grimley, P. M. , Barry, D. W. , and Schaff, Z. (1973) Induction of tubular structures in the endoplasmic reticulum of human lymphoid cells by treatment with 5‐bromo‐2′‐deoxyuridine. J.N C.I., 51: 1751–1760. [DOI] [PubMed] [Google Scholar]
  116. Grimley, P. M. , and Schaff, Z. S. (1976) Significance of tubuloreticular inclusions in the pathobiology of human disease In Ioachim H. L. (ed.): Pathobiology Annual. New York: Appleton‐Century‐Crofts, pp. 221–257. [PubMed] [Google Scholar]
  117. Groopman, J. E. , Hartzband, P. I. , Shulman, L. , Salahuddin, S. Z. , Sarngadharan, M. G. , McLane, M. F. , Essex, M. , and Gallo, R. (1985) Antibody seronegative human T‐lymphotropic virus type III (HTLV‐III)‐infected patients with acquired immunodeficiency syndrome or related disorders. Blood, 66: 742–744. [PubMed] [Google Scholar]
  118. Grossi, C. E. , Zicca, A. , Cadoni, A. , Mingari, M. C. , Moretta, A. , and Moretta, L. (1983) Ultra‐structural characteristics of human T‐cell clones with various cytolytic activities. Eur. J. Immunol., 13: 670–677. [DOI] [PubMed] [Google Scholar]
  119. Guarda, L. A. , Luna, M. A. , Smith, J. L. , Mansell, P. W. A. , Gyorkey, F. , and Roca, A. N. (1984) Acquired immune deficiency syndrome: Postmortem findings. Am. J. Clin. Pathol., 81: 549–557. [DOI] [PubMed] [Google Scholar]
  120. Gupta, P. , Balachandran, R. , Grovit, K. , Webster, D. , and Rinaldo, C., Jr. , (1987b) Detection of human immunodeficiency virus by reverse transcriptase assay, antigen capture assay, and radioimmunoassay. J. Clin. Microbiol., 25: 1122–1125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  121. Gupta, J. , Pilotti, S. , Shah, K. V. , DePalo, G. , and Rilke, F. (1987a) Human papillomavirus‐associated early vulvar neoplasia investigated by in situ hybridization. Am. J. Surg. Pathol., 11: 430–434. [DOI] [PubMed] [Google Scholar]
  122. Gürtler, L. G. , Eberle, J. , Lorbeer, B. , and Deinhardt, F. (1987) Sensitivity and specificity of commercial ELISA kits for screening anti‐LAV/HTLV‐III. J. Virol. Methods, 15: 11–23. [DOI] [PubMed] [Google Scholar]
  123. Gyger, M. , Laverdiere, M. , Gagnon, A. , Perreault, C. , Cousineau, S. , and Forest, L. (1985) 14q+ abnormality with probable t(8;14) (q24;q32) in a young Haitian immigrant with acquired immunodeficiency syndrome and concomitant Burkitt's‐like lymphoma. Cancer Genet. Cytogenet., 17: 283–288. [DOI] [PubMed] [Google Scholar]
  124. Gyorkey, F. , Melnick, J. L. , and Gyorkey, P. (1987) Human immunodeficiency virus in brain biopsies of patients with AIDS and progressive encephalopathy. J. Infect. Dis., 155: 870–871. [DOI] [PubMed] [Google Scholar]
  125. Hackman, R. C. , Myerson, D. , Meyers, J. D. , Shulman, H. M. , Sale, G. E. , Goldstein, L. C. , Rastetter, M. , Flournoy, N. , and Thomas, E. D. (1985) Rapid diagnosis of cytomegaloviral pneumonia by tissue immunofluorescence with a murine monoclonal antibody. J. Infect. Dis., 151: 325–329. [DOI] [PubMed] [Google Scholar]
  126. Hammar, S. P. , Bockus, D. , Remington, F. , and Friedman, S. (1984) More on ultrastructure of AIDS lymph nodes. N. Engl. J. Med., 310: 924–925. [DOI] [PubMed] [Google Scholar]
  127. Handler, C. E. , and Perkin, G. D. (1982) Radiculomyelopathy due to genital herpes. Lancet, 1: 987–988. [DOI] [PubMed] [Google Scholar]
  128. Harper, M. S. , Kaplan, M. H. , Marselle, L. M. , Pahwa, S. G. , Chayt, K. J. , Sarngadharan, M. G. , Wong‐Staal, F. , and Gallo, R. C. (1986) Concomitant infection with HTLV‐I and HTLV‐III in a patient with T8 lymphoproliferative disease. N. Engl. J. Med., 315: 1073–1078. [DOI] [PubMed] [Google Scholar]
  129. Hawley, D. A. , Schaefer, J. F. , Schulz, D. M. , and Muller, J. (1983) Cytomegalovirus encephalitis in acquired immunodeficiency syndrome. Am. J. Clin. Pathol., 80: 874–877. [DOI] [PubMed] [Google Scholar]
  130. Hayat, M. A. (1981) Fixation for Electron Microscopy. New York: Academic Press. [Google Scholar]
  131. Haynes, B. F. , Miller, S. E. , Palker, T. J. , Moore, J. O. , Dunn, P. H. , Bolognesi, D. P. , and Metzgar, R. S. (1983) Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis. Proc. Natl. Acad. Sci. U.S.A., 80: 2954–2958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  132. Heller, M. , Dix, R. D. , Baringer, J. R. , Schacter, J. , and Conte, J. E. (1982) Herpetic proctitis and meningitis: Recovery of two strains of herpes simplex virus type I from cerebrospinal fluid. J. Infect. Dis., 146: 584–588. [DOI] [PubMed] [Google Scholar]
  133. Henle, G. , Henle, W. , and Diehl, V. (1968) Relation of Burkitt's tumor‐associated herpes‐type virus to infectious mononucleosis. Proc. Natl. Acad. Sci. U.S.A., 59: 94–101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  134. Hierholzer, J. C. , Kemp, M. C. , Gary, G. W., Jr. , and Spencer, H. C. (1982) New human adenovirus associated with respiratory illness: Candidate adenovirus type 39. J. Clin. Microbiol., 16: 15–21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  135. Hinnant, K. L. , Rotterdam, H. Z. , Bell, E. T. , and Tapper, M. L. (1986) Cytomegalovirus infection of the alimentary tract: A clinicopathological correlation. Am. J. Gastroenterol., 81: 944–950. [PubMed] [Google Scholar]
  136. Hirsch, M. S. , and Schooley, R. T. (1983a) Treatment of herpesvirus infections. N. Engl. J. Med., 309: 963–970. [DOI] [PubMed] [Google Scholar]
  137. Hirsch, M. S. , and Schooley, R. T. (1983b) Treatment of herpesvirus infections. N. Engl. J. Med., 309: 1034–1039. [DOI] [PubMed] [Google Scholar]
  138. Ho, D. D. , Rota, T. R. , Schooley, R. T. , Kaplan, J. C. , Groopman, J. E. , Resnick, L. , Felsenstein, D. , Andrews, C. A. , and Hirsch, M. S. (1985) Isolation of HTLV‐III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N. Engl. J. Med., 313: 1493–1497. [DOI] [PubMed] [Google Scholar]
  139. Hoar, D. I. , Bowen, T. , Matheson, D. , and Poon, M. C. (1985) Hepatitis B virus DNA in patients with chronic liver disease and negative tests for hepatitis B surface antigen. N. Engl. J. Med., 312: 270–276. [DOI] [PubMed] [Google Scholar]
  140. Hogan, T. F. , Borden, E. D. , McBain, J. A. , Padgett, B. L. , and Walker, D. L. (1980) Human polyomavirus infections with JC virus and BK virus in renal transplant patients. Ann. Intern. Med., 92: 373–378. [DOI] [PubMed] [Google Scholar]
  141. Holland, G. N. (1985) Ocular manifestations of the acquired immunodeficiency syndrome. Int. Ophthalmol. Clin., 25 (2): 179–187. [DOI] [PubMed] [Google Scholar]
  142. Holland, G. N. , Sakamoto, M. J. , Hardy, D. , Sidikaro, Y. , Kreiger, A. E. , and Frenkel, L. M. (1986) Treatment of cytomegalovirus retinopathy in patients with acquired immunodeficiency syndrome. Use of the experimental drug 9‐‘2‐hydroxy‐1‐(hydroxymethyl)ethoxymethyl’guanine. Arch. Ophthalmol., 104: 1794–1800. [DOI] [PubMed] [Google Scholar]
  143. Hopkins, S. (1985) Clinical. A new approach to combat viruses. Nurs. Mirror, 160: 28–29. [PubMed] [Google Scholar]
  144. Horoupian, D. S. , Pick, P. , Spigland, I. , Smith, P. , Portenoy, R. , Katzman, R. , and Cho, S. (1984) Acquired immunodeficiency syndrome and multiple tract degeneration in a homosexual man. Ann. Neurol., 15: 502–505. [DOI] [PubMed] [Google Scholar]
  145. Horwitz, M. S. , Valderrama, G. , Hatcher, V. , Korn, R. , deJong, P. , and Spigland, I. (1984) Characterization adenovirus isolates from AIDS patients. Ann. N.Y. Acad. Sci., 437: 161–174. [DOI] [PubMed] [Google Scholar]
  146. Hsiung, G. D. (1982) Diagnostic Virology Illustrated by Light and Electron Microscopy. New Haven: Yale University Press. [Google Scholar]
  147. Huang, S.‐N. , and Fisher, M. M. (1987) Pathology of viral hepatitis In Farber E., Phillips M. J., and Kaufman N. (eds.): Pathogenesis of Liver Disease. Baltimore: Williams and Wilkins Co., pp. 153–198. [Google Scholar]
  148. Huang, E. S. , and Roche, J. K. (1978) Cytomegalovirus DNA and adenocarcinoma of the colon: Evidence for latent viral infection. Lancet, 1: 957–960. [DOI] [PubMed] [Google Scholar]
  149. Humphrey, R. C. , Parkin, J. M. , and Marsh, R. J. (1986) The ophthalmological features of AIDS and AIDS lated disorders. Trans. Ophthalmol. Soc. U.K., 105: 505–509. [PubMed] [Google Scholar]
  150. Jensen, O. A. (1985) Cytoplasmic structures in endothelial cells of the choroid. Ultrastruct. Pathol., 8: 375–379. [DOI] [PubMed] [Google Scholar]
  151. Jensen, O. A. , Gerstoft, J. , Thomsen, H. K. , and Marner, K. (1984) Cytomegalovirus retinitis in the acquired immunodeficiency syndrome (AIDS). Light microscopical, ultrastructural and immunohistochemical examination of a case. Acta Ophthalmol. (Copenh.), 62: 1–9. [DOI] [PubMed] [Google Scholar]
  152. Kanner, S. B. , Parks, E. S. , Scott, G. B. , and Parks, W. P. (1987) Simultaneous infections with human T cell leukemia virus type I and the human immunodeficiency virus. J. Infect. Dis., 155: 617–625. [DOI] [PubMed] [Google Scholar]
  153. Kapikian, A. Z. , Dienstag, J. L. , and Purcell, R. J. (1976) Immune electron microscopy as a method for the detection, identification and characterization of agents not cultivable in an in vitro system In Rose N. R. and Friedman H. (eds.): Manual of Clinical Immunology. Washington, DC: American Society for Microbiology, pp. 467–480. [Google Scholar]
  154. Katzman, M. , Elmets, C. A. , and Lederman, M. M. (1985) Molluscum contagiosum and the acquired immunodeficiency syndrome ‘letter’. Ann. Intern. Med., 102: 413–414. [DOI] [PubMed] [Google Scholar]
  155. Kavin, H. , Jonas, R. B. , Chowdhury, L. , and Kabins, S. (1986) Acalculous cholecystitis and cytomegalovirus infection in the acquired immunodeficiency syndrome. Ann. Intern. Med., 104: 53–54. [DOI] [PubMed] [Google Scholar]
  156. Kern, P. , Muller, G. , Schmitz, H. , Racz, P. , Meigel, W. , Riethmuller, G. , and Dietrich, M. (1985) Detection of coronavirus‐like particles in homosexual men with acquired immunodeficiency and related lymphadenopathy syndrome. Klin. Wochenschr., 63: 68–72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  157. Kiefer, D. J. , Phelps, D. A. , and Halbert, S. P. (1983) Normalized enzyme‐linked immunosorbent assay for detecting immunoglobulin G antibodies to cytomegalovirus. J. Clin. Microbiol., 18: 33–39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  158. Klein, G. (1979) The relationship of the virus to nasopharyngeal carcinoma In Epstein M. A. and Achong B. G. (eds.): The Epstein‐Barr Virus. New York: Springer‐Verlag, pp. 340–350. [Google Scholar]
  159. Knapp, A. B. , Horst, D. A. , Eliopoulos, G. , Gramm, H. F. , Gaber, L. W. , Falchuk, K. R. , Falchuk, Z. M. , and Trey, C. (1983) Widespread cytomegalovirus gastroenterocolitis in a patient with acquired immunodeficiency syndrome. Gastroenterology, 85: 1399–1402. [PubMed] [Google Scholar]
  160. Koenig, S. , Gendelman, H. E. , Orenstein, J. M. , DalCanto, M. C. , Pezeshkpour, G. H. , Yungbluth, M. , Janotta, F. , Aksamit, A. , Martin, M. A. , and Fauci, A. S. (1986) Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science, 233: 1089–1093. [DOI] [PubMed] [Google Scholar]
  161. Kostianovsky, M. , Kang, Y.‐H. , and Grimley, P. M. (1984) Ultrastructural and immunoelectron microscopic studies of cells with abnormal cytoplasmic inclusions in patients with AIDS. AIDS Res., 1: 181–196. [DOI] [PubMed] [Google Scholar]
  162. Kostianovsky, M. , Orenstein, J. M. , Schaff, Z. , and Grimley, P. M. (1987) Cytomembranous inclusions observed in acquired immunodeficiency syndrome. Arch. Pathol. Lab. Med., 111: 218–223. [PubMed] [Google Scholar]
  163. Kotler, D. P. , Culpepper‐Morgan, J. A. , Tierney, A. R. , and Klein, E. B. (1986) Treatment of disseminated cytomegalovirus infection with 9‐(1,3‐dihydroxy‐2‐propoxy‐methyl)guanine: Evidence of prolonged survival in patients with the acquired immunodeficiency syndrome. AIDS Res., 2: 299–307. [DOI] [PubMed] [Google Scholar]
  164. Kovi, J. , Tillman, L. , and Lee, S. M. (1974) Malignant transformation of condyloma acuminatum. Am. J. Clin. Pathol., 61: 702–710. [DOI] [PubMed] [Google Scholar]
  165. Krigel, R. L. (1984) The natural history and treatment of epidemic Kaposi's sarcoma. Ann. N.Y. Acad Sci., 437: 447–453. [DOI] [PubMed] [Google Scholar]
  166. Krupp, L. B. , Lipton, R. B. , Swerdlow, M. L. , Leeds, N. E. , and Llena, J. (1985) Progressive multifocal leukoencephalopathy: Clinical and radiographic features. Ann. Neurol., 17: 344–349. [DOI] [PubMed] [Google Scholar]
  167. Landay, A. , Poon, M. C. , Abo, T. , Stagno, S. , Lurie, A. , and Cooper, M. D. (1983) Immunologic studies in asymptomatic hemophilia patients. Relationship to acquired immune deficiency syndrome (AIDS). J. Clin. Invest., 71: 1500–1504. [DOI] [PMC free article] [PubMed] [Google Scholar]
  168. Lane, H. C. , Masur, H. , Gelmann, E. P. , and Fauci, A. S. (1985) Therapeutic approaches to patients with AIDS. Cancer Res. ‘Suppl.’, 45: 4674S–4676S. [PubMed] [Google Scholar]
  169. Larson, H. E. , Reed, S. E. , and Tyrrell, D. A. J. (1980) Isolation of rhinoviruses and coronaviruses from 38 colds in adults. J. Med. Virol., 5: 221–229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  170. Laskin, O. L. , Stahl‐Bayliss, C. M. , Kalman, C. M. , and Rosecan, L. R. (1987) Use of ganciclovir to treat serious cytomegalovirus infections in patients with AIDS. J. Infect. Dis., 155: 323–327. [DOI] [PubMed] [Google Scholar]
  171. Laure, F. , Zagury, D. , Saimot, A. G. , Gallo, R. C. , Hahn, B. H. , and Brechot, C. (1985) Hepatitis B virus DNA sequences in lymphoid cells from patients with AIDS and AIDS‐related complex. Science, 229: 561–563. [DOI] [PubMed] [Google Scholar]
  172. Levinson, W. , and Bennetts, R. W. (1985) Cytomegalovirus colitis in acquired immunodeficiency syndrome—a chronic disease with varying manifestations. Am. J. Gastroenterol., 80: 445–447. [PubMed] [Google Scholar]
  173. Levy, R. M. , Bredesen, D. E. , and Rosenblum, M. L. (1985) Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): Experience at UCSF and review of the literature. Neurosurgery, 62: 475–495. [DOI] [PubMed] [Google Scholar]
  174. Levy, J. A. , Hoffman, A. D. , Kramer, S. M. , Landi, J. A. , and Shimabukuro, J. M. (1984) Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. Science, 225: 840–842. [DOI] [PubMed] [Google Scholar]
  175. Lie‐Injo, L. E. , Volberding, P. , Golden, J. A. , and Herrera, A. R. (1985) Hepatitis B virus (HBV) DNA in leucocytes in acquired immune deficiency syndrome (AIDS). Cytobios, 44: 119–128. [PubMed] [Google Scholar]
  176. Lindahl, T. , Klein, G. , Reedman, B. M. , Johansson, B. , and Singh, S. (1974) Relationship between Epstein‐Barr virus (EBV) DNA and the EBV‐determined nuclear antigen (EBNA) in Burkitt lymphoma biopsies and other lymphoproliferative malignancies. Int. J. Cancer, 13: 764–772. [DOI] [PubMed] [Google Scholar]
  177. Lipscomb, H. , Tatsumi, E. , Harada, S. , Yetz, J. , Davis, J. , Bechtold, T. , Volsky, D. J. , Kuszynski, C. , Purtilo, D. T. , Sonnabend, J. , Wallace, J. , McClain, K. , Metroka, C. , and Tubbs, R. (1983–1984) Epstein‐Barr virus and chronic lymphadenopathy in male homosexuals with acquired immunodeficiency syndrome (AIDS). AIDS Res., 1: 59–82. [DOI] [PubMed] [Google Scholar]
  178. Lo, S. C. (1986) Isolation and identification of a novel virus from patients with AIDS. Am. J. Trop. Med. Hyg., 35: 675–676. [DOI] [PubMed] [Google Scholar]
  179. Lombardo, P. C. (1985) Molluscum contagiosum and the acquired immunodeficiency syndrome ‘letter’. Arch. Dermatol., 121: 834–835. [PubMed] [Google Scholar]
  180. Maass, G. , and Baumeister, N. G. (1983) Coronavirus‐like particles as aetiological agents of acute non‐bacterial gastroenteritis in humans. Dev. Biol. Stand., 53: 319–324. [PubMed] [Google Scholar]
  181. Macher, A. M. , Reichert, C. M. , Straus, S. E. , Longo, D. L. , Parrillo, J. , Lane, H. C. , Fauci, A. S. , Rook, A. H. , Manischewitz, J. F. , and Quinnan, G. V. (1983) Death in the AIDS patient: Role of cytomegalovirus. N. Engl. J. Med., 309: 1454. [DOI] [PubMed] [Google Scholar]
  182. MacNaughton, M. R. (1982) Occurrence and frequency of coronavirus infection in humans as determined by enzyme‐linked immunosorbent assay. Infect. Immun. 38: 419–423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  183. Maier, J. A. , Bergman, A. , and Ross, M. G. (1986) Acquired immunodeficiency syndrome manifested by chronic primary genital herpes. Am. J. Obstet. Gynecol., 155: 756–758. [DOI] [PubMed] [Google Scholar]
  184. Malherbe, H. H. , and Strickland‐Cholmley, M. (1980) Viral Cytopathology. Boca Raton, FL: CRC Press. [Google Scholar]
  185. Markham, P. D. , Salahuddin, S. Z. , Popovic, M. , Patel, A. , Veren, K. , Fladeger, A. , Orndorff, S. , and Gallo, R. C. (1985) Advances in the isolation of HTLV‐III from patients with AIDS and AIDS‐related complex and donors at risk. Cancer Res. ‘Suppl.’, 45: 4588S–4591S. [PubMed] [Google Scholar]
  186. Martin, K. , Katz, B. Z. , and Miller, G. (1986) AIDS and antibodies to human immunodeficiency virus (HIV) in children and their families. J. Infect. Dis., 155: 54–63. [DOI] [PubMed] [Google Scholar]
  187. McCance, D. J. (1987) Human papillomavirus and cervical cancer. Lancet, 1: 986. [PubMed] [Google Scholar]
  188. McCance, D. J. (1987) Human papillomavirus and cervical cancer. Lancet, 1: 986. [PubMed] [Google Scholar]
  189. McIntosh, K. (1974) Coronaviruses: A comparative review. Curr. Top. Microbiol. Immunol., 63: 85–129. [Google Scholar]
  190. McKeating, J. A. , Al‐Nakib, W. , Grenaway, P. J. , and Griffiths, P. D. (1985) Detection of cytomegalovirus in urine samples by enzyme‐linked immunosorbent assay. J. Med. Virol., 16: 367–373. [DOI] [PubMed] [Google Scholar]
  191. McKeever, P. E. , Chronwall, B. M. , Houff, S. A. , Sever, J. L. , Kornblith, P. L. , Padgett, B. L. , Walker, D. L. , and London, W. T. (1983) Glial and divergent cells in primate central nervous system tumors induced by JC virus isolated from human progressive multifocal leukoencephalopathy (PML) In Madden D. L. and Sever J. L. (eds.): Polyomaviruses and Human Neurological Diseases. New York: Alan R. Liss, Inc., pp. 239–251. [PubMed] [Google Scholar]
  192. Meiselman, M. S. , Cello, J. P. , and Margaretten, W. (1985) Cytomegalovirus colitis. Report of the clinical, endoscopic, and pathologic findings in two patients with the acquired immune deficiency syndrome. Gastroenterology, 88: 171–175. [DOI] [PubMed] [Google Scholar]
  193. Melnick, J. L. , Lewis, R. , Wimberly, I. , Kaufman, R. H. , and Adams, E. (1978) Association of cytomegalovirus (CMV) infection with cervical cancer: Isolation of CMV from cell cultures derived from cervical biopsy. Intervirology, 10: 115–119. [DOI] [PubMed] [Google Scholar]
  194. Miller, S. E. (1986) Detection and identification of viruses by electron microscopy. J. Electron Microsc. Tech., 4: 265–301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  195. Miller, S. E. , and Lang, D. J. (1982) Rapid diagnosis of herpes simplex infection: Amplification for electron microscopy by short term in vitro replication. J. Infect., 4: 37–41. [DOI] [PubMed] [Google Scholar]
  196. Miller, S. E. , and Rogers, J. F. (1984) Ultrastructure in AIDS ‘letter’. N. Engl. J. Med., 309: 1189–1190. [Google Scholar]
  197. Miller, J. R. , Barrett, R. E. , Britton, C. B. , Tapper, M. L. , Bahr, G. S. , Bruno, P. J. , Marquardt, M. D. , Hays, A. P. , McMurtry, J. G. , Weissman, J. B. , and Bruno, M. S. (1982) Progressive multifocal leukoencephalopathy in a male homosexual with T‐cell immune deficiency. N. Engl. J. Med., 307: 1436–1438. [DOI] [PubMed] [Google Scholar]
  198. Mindel, A. , Kinghorn, G. , Allason‐Jones, E. , Woolley, P. , Barton, I. , Faherty, A. , Jeavons, M. , Williams, P. , and Patou, G. (1987) Treatment of first‐attack genital herpes—acyclovir versus inosine pranobex. Lancet 1: 1171–1173. [DOI] [PubMed] [Google Scholar]
  199. Mok, J. Q. , Giaquinto, C. , DeRossi, A. , Grosch‐Wörner, I. , Ades, A. E. , and Peckham, C. S. (1987) Infants born to mothers seropositive for human immunodeficiency virus. Lancet, 1: 1164–1167. [DOI] [PubMed] [Google Scholar]
  200. Monroe, J. E. , Andrews, C. , Sullivan, J. L. , and Mulder, C. (1987) Use of cytoplasmic dot‐blot hybridization to detect human immunodeficiency virus RNA sequences in cultures of peripheral blood. J. Infect. Dis., 155: 320–322. [DOI] [PubMed] [Google Scholar]
  201. Montagnier, L. (1986) Lymphadenopathy associated virus: Its role in the pathogenesis of AIDS and related diseases. Prog. Allergy, 37: 46–64. [PubMed] [Google Scholar]
  202. Montagnier, L. , Chermann, J. C. , Barre‐Sinoussi, F. , Klatzmann, D. , Wain‐Hobson, S. , Alizon, M. , Clavel, F. , Brun‐Vezinet, F. , Vilmer, E. , Rouzioux, C. , Rozenbaum, W. , and Gluckman, J. C. (1984) Lymphadenopathy associated virus and its etiological role in AIDS. Int. Symp. Princess Takamatsu Cancer Res. Fund, 15: 319–331. [PubMed] [Google Scholar]
  203. Mosca, J. D. , Bednarik, D. P. , Raj, N. B. K. , Rosen, C. A. , Sodroski, J. G. , Haseltine, W. A. , and Pitha, P. M. (1987) Herpes simplex virus type 1 can reactivate human immunodeficiency virus. Nature, 325: 67–70. [DOI] [PubMed] [Google Scholar]
  204. Moskowitz, L. B. , Gregorios, J. B. , Hensley, G. T. , and Berger, J. R. (1984) Cytomegalovirus. Induced demyelination associated with acquired immmune deficiency syndrome. Arch. Pathol. Lab. Med., 108: 873–877. [PubMed] [Google Scholar]
  205. Muñoz, D. G. , Perl, D. P. , Pendlebury, W. W. , and Highland, R. A. (1987) Comparison of cytomegalovirus infection of brain and lung in a patient with subacute encephalopathy of acquired immunodeficiency syndrome. Arch. Pathol. Lab. Med., 111: 234–237. [PubMed] [Google Scholar]
  206. Murphy, G. F. , Kwan, T. H. , and Mihm, M. C. (1984) The skin In Robbins S. L., Cotran R. S., and Kumar V. (eds.): Pathologic Basis of Disease. Philadelphia: W.B. Saunders Co., pp. 1257–1303. [Google Scholar]
  207. Murray, B. J. (1987) Medical complications of herpes zoster in immunocompetent patients. Postgrad. Med., 81: 229–236. [DOI] [PubMed] [Google Scholar]
  208. Myerson, D. , Hackman, R. C. , and Meyers, J. D. (1984) Diagnosis of cytomegalovirus pneumonia by in situ hybridization. J. Infect. Dis., 150: 272–277. [DOI] [PubMed] [Google Scholar]
  209. Nahmias, A. J. , Whitley, R. J. , Visintine, A. N. , Takei, Y. , Alford, C. A. , and the Collaborative Antiviral Study Group (1982) Herpes simplex virus encephalitis: Laboratory evaluations and their diagnostic significance. J. Infect. Dis., 145: 829–836. [DOI] [PubMed] [Google Scholar]
  210. Narayan, O. , Penney, J. B., Jr. , Johnson, R. T. , Herndon, R. M. , and Weiner, L. P. (1973) Etiology of progressive multifocal leukoencephalopathy. Identification of papovavirus. N. Engl. J. Med., 289: 1278–1282. [DOI] [PubMed] [Google Scholar]
  211. Nash, G. (1982) Pathologic features of the lung in the immunocompromised host. Prog. Pathol., 13: 841–858. [DOI] [PubMed] [Google Scholar]
  212. Nath, N. , Fang, C. , Wunderlich, C. , Dodd, R. Y. , and Tegtmeier, G. (1987) A test for human cytomegalovirus‐specific immunoglobulins using a modification of a commercial test kit. J. Virol. Methods, 15: 223–231. [DOI] [PubMed] [Google Scholar]
  213. Neuwirth, J. , Gutman, I. , Hofeldt, A. J. , Behrens, M. , Marquardt, M. D. , Abramovsky‐Kaplan, I. , Kelsey, P. , and Odel, J. (1982) Cytomegalovirus retinitis in a young homosexual male with acquired immunodeficiency. Ophthalmology, 89: 805–808. [DOI] [PubMed] [Google Scholar]
  214. Noonan, C. A. , Yoffe, B. , Mansell, P. W. , Melnick, J. L. , and Hollinger, F. B. (1986) Extrachromosomal sequences of hepatitis B virus DNA in peripheral blood mononuclear cells of acquired immune deficiency syndrome patients. Proc. Natl. Acad. Sci. U.S.A., 83: 5698–5702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  215. Olsen, R. G. , Tarr, J. J. , Mathes, L. E. , Whisler, R. , Du Plessis, D. , Schulz, E. J. , and Blakeslee, J. R. (1987) Serological and virological evidence of human T‐lymphotropic virus in systemic lupus erythematosus. Med. Microbiol. Immunol. (Berl.), 176: 53–64. [DOI] [PubMed] [Google Scholar]
  216. Omata, M. , Afroudakis, A. , Liew, C.‐T. , Ashcavai, M. , and Peters, R. L. (1978) Comparison of serum hepatitis B surface antigen (HBsAg) and serum anticore with tissue HBsAg and hepatitis B core antigen (HBcAg). Gastroenterology, 75: 1003–1009. [PubMed] [Google Scholar]
  217. Orenstein, J. M. (1983) Ultrastructural markers in AIDS. Lancet, 2: 284–285. [PubMed] [Google Scholar]
  218. Padgett, B. L. , and Walker, D. L. (1976) New human papovaviruses. Prog. Med. Virol., 22: 1–35. [PubMed] [Google Scholar]
  219. Padgett, B. L. , and Walker, D. L. (1983) Virologic and serologic studies of progressive multifocal leukoencephalopathy In Sever J. L. and Madden D. L. (eds.): Polyomaviruses and Human Neurological Diseases. New York: Alan R. Liss, Inc., pp. 107–117. [PubMed] [Google Scholar]
  220. Pahwa, S. , Kaplan, M. , Fikrig, S. , Pahwa, R. , Sarngadharan, M. G. , Popovic, M. , and Gallo, R. C. (1986) Spectrum of human T‐cell lymphotropic virus type III infection in children: Recognition of symptomatic, asymptomatic, and seronegative patients. J.A.M.A., 255: 2299–2305. [PubMed] [Google Scholar]
  221. Palestine, A. G. , Rodrigues, M. M. , Macher, A. M. , Chan, C.‐C. , Lane, H. C. , Fauci, A. S. , Masur, H. , Longo, D. , Reichert, C. M. , Steis, R. , Rook, A. H. , and Nussenblatt, R. B. (1984) Ophthalmic involvement in acquired immunodeficiency syndrome. Ophthalmology, 91: 1092–1099. [DOI] [PubMed] [Google Scholar]
  222. Palestine, A. G. , Stevens, G., Jr. , Lane, H. C. , Masur, H. , Fujikawa, L. S. , Nussenblatt, R. B. , Rook, A. H. , Manischewitz, J. , Baird, B. , Megill, M. , Quinnan, G. , Gelmann, E. , and Fauci, A. S. (1986) Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine. Am. J. Ophthalmol., 101: 95–101. [DOI] [PubMed] [Google Scholar]
  223. Palmer, E. , and Goldsmith, C. S. (1988) Ultrastructure of human retroviruses. J. Electron Microsc. Tech., 8: 3–15. [DOI] [PubMed] [Google Scholar]
  224. Palmer, E. L. , Harrison, A. K. , Ramsey, R. , Feorino, P. , Francis, D. , Evatt, B. , Kalyanaraman, V. S. , and Martin, M. L. (1983) Detection of two human T cell leukemia/lymphotropic viruses in cultured lymphocytes of a hemophiliac with AIDS. J. Infect. Dis., 151: 559–563. [DOI] [PubMed] [Google Scholar]
  225. Payne, C. M. E. , Farthing, C. , Byrom, N. , and Stoughton, R. C. D. (1984) Shingles in seven homosexuals. Lancet, 1: 103–104. [DOI] [PubMed] [Google Scholar]
  226. Pearson, G. R. , Weiland, L. H. , Neel, H. B., III , Taylor, W. , Earle, J. , Mulroney, S. E. , Goepfert, H. , Lanier, A. , Talvot, M. L. , Pilch, B. , Goodman, M. , Huang, A. , Levines, P. H. , Hyams, V. , Moran, E. , Henle, G. , and Henle, W. (1983) Application of Epstein‐Barr virus (EBV) serology to the diagnosis of North American nasopharyngeal carcinoma. Cancer, 51: 260–268. [DOI] [PubMed] [Google Scholar]
  227. Pekovic, D. , Garzon, S. , Strykowski, H. , Ajdukovic, D. , Gorintsky, M. , and Dupuy, J. M. (1986) Immunogold labeling of HTLV III/LAV in H9 cells studied by transmission electron microscopy. J. Virol. Methods, 13: 265–269. [DOI] [PubMed] [Google Scholar]
  228. Penneys, N. S. , and Hicks, B. (1985) Unusual cutaneous lesions associated with acquired immunodeficiency syndrome. J. Am. Acad. Dermatol., 13: 845–852. [DOI] [PubMed] [Google Scholar]
  229. Pepose, J. S. , Kreiger, A. E. , Tomiyasu, U. , Cancilla, P. A. , and Foos, R. Y. (1985) Immunocyologic localization of herpes simplex type 1 viral antigens in herpetic retinitis and encephalitis in an adult. Ophthalmology, 92: 160–166. [DOI] [PubMed] [Google Scholar]
  230. Pepose, J. S. , Nestor, M. S. , Holland, G. N. , Cochran, A. J. , and Foos, R. Y. (1983) An analysis of retinal cotton‐wool spots and cytomegalovirus retinitis in the acquired immunodeficiency syndrome ‘letter’. Am. J. Ophthalmol., 95: 118–120. [DOI] [PubMed] [Google Scholar]
  231. Peters, A. C. B. , Versteeg, J. , Bots, G. T. A. M. , Boogerd, W. , and Vielvoye, J. (1980) Progressive multifocal leukoencephalopathy. Immunofluorescent demonstration of simian virus 40 antigen in CSF cells and response to cytarabine therapy. Arch. Neurol., 37: 497–501. [DOI] [PubMed] [Google Scholar]
  232. Petersen, J. M. , Tubbs, R. R. , Savage, R. A. , Calabrese, L. C. , Proffitt, M. R. , Manolova, Y. , Manolov, G. , Shumaker, A. , Tatsumi, E. , McClain, K. , and Purtilo, D. T. (1985) Small noncleaved B cell Burkitt‐like lymphoma with chromosome t(8:14) translocation and Epstein‐Barr virus nuclear‐associated antigen in a homosexual man with acquired immune deficiency syndrome. Am. J. Med., 78: 141–148. [DOI] [PubMed] [Google Scholar]
  233. Petito, C. K. , Cho, E.‐S. , Lemann, W. , Navia, B. A. , and Price, R. W. (1986) Neuropathology of acquired immunodeficiency syndrome (AIDS): An autopsy review. J. Neuropathol. Exp. Neurol., 45: 635–646. [DOI] [PubMed] [Google Scholar]
  234. Pi, G. H. , Desgranges, C. , Bornkam, G. W. , Shen, S. J. , Zeng, Y. , and De The, G. (1983) Comparative evaluation of various techniques to detect EBV DNA in exfoliated nasopharyngeal cells. Ann. Virol. (Inst. Pasteur), 134E: 21–32. [Google Scholar]
  235. Poiesz, B. J. , Ruscetti, F. W. , Gazdar, A. F. , Bunn, P. A. , Minna, J. D. , and Gallo, R. C. (1980) Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T‐cell lymphoma. Proc. Natl. Acad. Sci. U.S.A., 77: 7415–7419. [DOI] [PMC free article] [PubMed] [Google Scholar]
  236. Pompidou A., Delsaux , M. C., Telvi , L., Mace B. , Coutance, F. , Falkenrodt, A. , and Lang, J. M. (1985) Isoprinosine and imuthiol, two potentially active compounds in patients with AIDS‐related complex symptoms. Cancer Res. ‘Suppl.’, 45: 4671S–4673S. [PubMed] [Google Scholar]
  237. Popovic, M. , Sarngadharan, M. G. , Read, E. , and Gallo, R. C. (1984) Detection, isolation, and continuous production of cytoplasmic retroviruses (HTLV‐III) from patients with AIDS and pre‐AIDS. Science, 224: 497–500. [DOI] [PubMed] [Google Scholar]
  238. Post, M. J. , Hensley, G. T. , Moskowitz, L. B. , and Fischl, M. (1986) Cytomegalic inclusion virus encephalitis in patients with AIDS: CT, clinical, and pathologic correlation. Am. J. Roentgenol., 146: 1229–1234. [DOI] [PubMed] [Google Scholar]
  239. Prineas, J. W. (1978) Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis. Lab. Invest., 38: 409–421. [PubMed] [Google Scholar]
  240. Purtilo, D. T. , Tatsumi, E. , Manolov, G. , Manolova, Y. , Harada, S. , Lipscomb, H. , and Krueger, G. (1985) Epstein‐Barr virus as an etiological agent in the pathogenesis of lymphoproliferative and aproliferative diseases in immune deficient patients. Int. Rev. Exp. Pathol., 27: 113–183. [PubMed] [Google Scholar]
  241. Quinnan, G. V., Jr. , Masur, H. , Rook, A. H. , Armstrong, G. , Frederick, W. R. , Epstein, J. , Manischewitz, J. F. , Macher, A. M. , Jackson, L. , Ames, J. , and Smith, H. (1984) Herpesvirus infections in the acquired immune deficiency syndrome. J.A.M.A. 252: 72–77. [PubMed] [Google Scholar]
  242. Ragona, G. , Sirianni, M. C. , Soddu, S. , Vercelli, B. V. , Sebastiani, G. , Piccoli, M. , and Aiuti, F. (1986) Evidence for disregulation in the control of Epstein‐Barr virus latency in patients with AIDS‐related complex. Clin. Exp. Immunol., 66: 17–24. [PMC free article] [PubMed] [Google Scholar]
  243. Rapp, F. (1984) Cytomegalovirus and carcinogenesis. J.N.C.I., 72: 783–787. [PubMed] [Google Scholar]
  244. Ratner, L. , Gallo., R. C. , and Wong‐Staal, F. (1985) HTLV‐III, LAV, ARV are variants of the same virus. Nature, 313: 636–637. [DOI] [PubMed] [Google Scholar]
  245. Ray, M. B. , Desmet, V. J. , Bradburne, A. F. , Desmyter, J. , Fevery, J. , and De Groote, J. (1976) Differential distribution of hepatitis B surface antigen and hepatitis B core antigen in the liver of hepatitis B patients. Gastroenterology, 71: 462–467. [PubMed] [Google Scholar]
  246. Redfield, R. R. , James, W. D. , Wright, D. C. , Brown, C. , Salahuddin, S. Z. , Markham, P. D. , Sarngadharan, M. G. , Folks, T. F. , and Gallo, R. C. (1985) Severe molluscum contagiosum infection in a patient with human T cell lymphotropic (HTLV‐III) disease. J. Am. Acad. Dermatol., 13: 821–824. [DOI] [PubMed] [Google Scholar]
  247. Rich, S. A. (1981) Human lupus inclusions and interferon. Science 213: 772–775. [DOI] [PubMed] [Google Scholar]
  248. Richardson, E. P., Jr. , and Webster, H. de F. (1983) Progressive multifocal leukoencephalopathy: Its pathological features In Madden D. L. and Sever J. L. (eds.): Polyomaviruses and Human Neurological Disease. New York: Alan R. Liss, Inc., pp. 191–203. [PubMed] [Google Scholar]
  249. Rico, M. J. , and Penneys, N. S. (1985) Cutaneous cryptococcosis resembling molluscum contagiosum in a patient with AIDS. Arch. Dermatol., 121: 901–902. [PubMed] [Google Scholar]
  250. Rinaldo, C. R., Jr. , Kingsley, L. A. , Lyter, D. W. , Rabin, B. S. , Atchison, R. W. , Bodner, A. J. , Weiss, S. H. , and Saxinger, W. C. (1986) Association of HTLV‐III with Epstein‐Barr virus infection and abnormalities of T lymphocytes in homosexual men. J. Infect. Dis., 154: 556–561. [DOI] [PubMed] [Google Scholar]
  251. Roche, J. K. , Cheung, K. S. , Boldogh, I. , Huang, E. S. , and Lang, D. J. (1981) Cytomegalovirus: Detection in human colonic and circulating mononuclear cells in association with gastrointestinal disease. Int. J. Cancer, 27: 659–667. [DOI] [PubMed] [Google Scholar]
  252. Rodrigues, M. M. , Palestine, A. , Nussenblatt, R. , Masur, H. , and Macher, A. M. (1983) Unilateral cytomegalovirus retinochoroiditis and bilateral cytoid bodies in a bisexual man with the acquired immunodeficiency syndrome. Ophthalmology, 90: 1577–1582. [PubMed] [Google Scholar]
  253. Romet‐Lemonne, J.‐L. , McLane, M. F. , Elfassi, E. , Haseltine, W. A. , Azocar, J. , and Essex, M. (1983) Hepatitis B virus infection in cultured human lymphoblastoid cells. Science, 221: 667–669. [DOI] [PubMed] [Google Scholar]
  254. Rosecan, L. R. , Stahl‐Bayliss, C. M. , Kalman, C. M. , and Laskin, O. L. (1986) Antiviral therapy for cytomegalovirus retinitis in AIDS with dihydroxy propoxymethyl guanine. Am. J. Ophthalmol., 101: 405–418. [DOI] [PubMed] [Google Scholar]
  255. Rosenberg, N. L. , Hochberg, F. H. , Miller, G. , and Kleinschmidt‐DeMasters, B. K. (1986) Primary central nervous system lymphoma related to Epstein‐Barr virus in a patient with acquired immune deficiency syndrome. Ann. Neurol., 20: 98–102. [DOI] [PubMed] [Google Scholar]
  256. Rossier, E. , Demock, K. , Taylor, D. , Larose, Y. , Phipps, P. H. , and Brodeur, B. (1987) Sensitivity and specificity of enzyme immunofiltration and DNA hybridization for the detection of HCMV‐infected cells. J. Virol. Methods, 15: 109–120. [DOI] [PubMed] [Google Scholar]
  257. Rothchild H., and Cohen J. C., (eds.) (1986) Virology in Medicine. New York: Oxford University Press. [Google Scholar]
  258. Rubinstein, A. (1983) Acquired immunodeficiency syndrome in infants. Am. J. Dis. Child., 137: 825–827. [DOI] [PubMed] [Google Scholar]
  259. Rübsamen‐Waigmann, H. , Becker, W. B. , Helm, E. B. , Brodt, R. , Fischer, H. , Henco, K. , and Drede, H. D. (1986) Isolation of variants of lymphocytopathic retroviruses from the peripheral blood and cerebrospinal fluid of patients with ARC and AIDS. J. Med. Virol., 19: 335–344. [DOI] [PubMed] [Google Scholar]
  260. Rustigi, V. K. , Hoofnagle, J. H. , Gerin, J. L. , Gelmann, E. P. , Reichert, C. M. , Cooper, J. N. , and Macher, A. M. (1984) Hepatitis B virus infection in the acquired immunodeficiency syndrome. Ann. Intern. Med., 101: 795–797. [DOI] [PubMed] [Google Scholar]
  261. Ryder, J. W. , Croen, K. , Kleinschmidt‐DeMasters, B. K. , Ostrove, J. M. , Straus, S. E. , and Cohn, D. L. (1986) Progressive encephalitis three months after resolution of cutaneous zoster in a patient with AIDS. Ann. Neurol., 19: 182–188. [DOI] [PubMed] [Google Scholar]
  262. Sacks, S. L. , and Freeman, H. J. (1984) Cytomegalovirus hepatitis: Evidence for direct hepatic viral infection using monoclonal antibodies. Gastroenterology, 86: 346–352. [PubMed] [Google Scholar]
  263. Salahuddin, S. Z. , Groopman, J. E. , Markham, P. D. , Sarngadharan, M. G. , Redfield, R. R. , McLane, M. F. , Essex, M. , Sliski, A. , and Gallo, R. (1984) HTLV‐III in symptom‐free seronegative persons. Lancet, 2: 1418–1420. [DOI] [PubMed] [Google Scholar]
  264. Sandor, E. V. , Millman, A. , Croxson, T. S. , and Mildvan, D. (1986) Herpes zoster ophthalmicus in patients at risk for the acquired immune deficiency syndrome (AIDS). Am. J. Ophthalmol., 101: 153–155. [DOI] [PubMed] [Google Scholar]
  265. Sanford, E. , Geder, L. , Laychock, A. , Rohner, T. , and Rapp, F. (1977) Evidence for the association of cytomegalovirus with carcinoma of the prostate. J. Urol., 118: 789–792. [DOI] [PubMed] [Google Scholar]
  266. Sarma, D. P. , and Weilbaecher, T. G. (1985) Molluscum contagiosum in the acquired immunodeficiency syndrome ‘letter’. J. Am. Acad. Dermatol., 13: 682–683. [DOI] [PubMed] [Google Scholar]
  267. Sarngadharan, M. G. , DeVico, A. L. , Bruch, L. , Schüpbach, J. , and Gallo, R. C. (1985) HTLV‐III: The etiologic agent of AIDS. Int. Symp. Princess Takamatsu Cancer Res. Fund, 15: 319–331. [PubMed] [Google Scholar]
  268. Sarngadharan, M. G. , Popovic, M. , Bruch, L. , Schüpbach, J. , and Gallo, R. C. (1984) Antibodies reactive with human T lymphotropic retrovirus (HTLV‐III) in the serum of patients with AIDS. Science, 224: 506–508. [DOI] [PubMed] [Google Scholar]
  269. Sarwar, M. , Falkoff, G. , and Naseem, M. (1986) Radiologic techniques in the diagnosis of CNS infections. Neurol. Clin., 4: 41–68. [PubMed] [Google Scholar]
  270. Schaff, Z. S. , Lapis, K. , Keresztury, S. , Kollath, Z. , and Hellos, I. (1982) Occurrence of tubuloreticular inclusions in acute viral hepatitis. Ultrastruct. Pathol., 3: 169–173. [DOI] [PubMed] [Google Scholar]
  271. Schaff, Z. , Tabor, E. , Jackson, D. R. , and Gerety, R. J. (1983) AIDS‐associated ultrastructural changes. Lancet, 1: 1336. [DOI] [PubMed] [Google Scholar]
  272. Schechter, M. T. , Boyko, W. J. , Jeffries, E. , Willoughby, B. , Nitz, R. , Constance, P. , Weaver, M. , Wiggs, B. , and O'Shaughnessy, M. (1985) The Vancouver Lymphadenopathy‐AIDS study: 4. Effects of exposure factors, cofactors and HTLV‐III seropositivity on number of helper T cells. Can. Med. Assoc. J., 133: 286–292. [PMC free article] [PubMed] [Google Scholar]
  273. Schenk, P. , Konrad, K. , and Rappersberger, K. (1986) Tubuloreticular structures in peripheral blood cells from patients with AIDS‐associated Kaposi's sarcoma. Arch. Dermatol. Res., 278: 249–251. [DOI] [PubMed] [Google Scholar]
  274. Schroth, G. , Gawehn, J. , Thron, A. , Vallbracht, A. , and Voigt, K. (1987) Early diagnosis of herpes simplex encephalitis by MRI. Neurology, 37: 179–183. [DOI] [PubMed] [Google Scholar]
  275. Schulman, H. M. , Hackman, R. C. , Sale, G. E. , and Meyers, J. D. (1982) Rapid cytologic diagnosis of cytomegalovirus interstitial pneumonia on touch imprints from open‐lung biopsy. Am. J. Clin. Pathol., 77: 90–94. [DOI] [PubMed] [Google Scholar]
  276. Schüpbach, J. , Popovic, M. , Gilden, R. V. , Gonda, M. , Sarngadharan, M. G. , and Gallo, R. C. (1984) Serological analysis of a subgroup of human T‐lymphotropic retroviruses (HTLV‐III) associated with AIDS. Science, 224: 503–505. [DOI] [PubMed] [Google Scholar]
  277. Scott, G. B. , Buck, B. E. , Leterman, J. G. , Bloom, F. L. , and Parks, W. P. (1984) Acquired immunodeficiency syndrome in infants. N. Engl. J. Med., 310: 76–81. [DOI] [PubMed] [Google Scholar]
  278. Scotto, J. , Hadchouel, M. , Hery, M. , Yvart, J. , Tiollais, P. , and Brechot, C. (1983) Detection of hepatitis B virus DNA in serum by a simple spot hybridization technique: Comparison with results for other viral markers. Hepatology, 3: 279–284. [DOI] [PubMed] [Google Scholar]
  279. Shamoto, M. , Murakami, S. , and Zenke, T. (1981) Adult T cell leukemia in Japan: An ultrastructural study. Cancer, 47: 1804–1811. [DOI] [PubMed] [Google Scholar]
  280. Sharp, D. G. (1960) Sedimentation counting of particles via electron microscopy In Bargmann W. (ed.): Proceedings of the Fourth International Congress of Electron Microscopy. Berlin: Springer‐Verlag, Vol. 2, pp. 542–548. [Google Scholar]
  281. Shaw, G. M. , Hahn, B. H. , Arya, S. K. , Groopman, J. E. , Gallo, R. C. , and Wong‐Staal, F. (1984) Molecular characterization of HTLV‐III in AIDS. Science, 226: 1165–1168. [DOI] [PubMed] [Google Scholar]
  282. Shepp, D. H. , Dandliker, P. S. , and Meyers, J. D. (1986) Treatment of varicella‐zoster virus infection in severely immunocompromised patients. N. Engl. J. Med., 314: 208–214. [DOI] [PubMed] [Google Scholar]
  283. Sheridan, J. F. , Aurelian, L. , and Quinn, T. C. (1984) Modulation of virus‐specific immunity in vitro by the addition of interleukin‐1 and interleukin‐2 in patients with the acquired immune deficiency syndrome. Ann. N.Y. Acad. Sci., 437: 530–534. [DOI] [PubMed] [Google Scholar]
  284. Sherlock, C. H. , and Corey, L. (1985) Adenosine monophosphate for the treatment of varicella zoster infections: A large dose of caution (Editorial). J.A.M.A., 253: 1444–1445. [PubMed] [Google Scholar]
  285. Siddiqui, A. (1983) Hepatitis B virus DNA in Kaposi's sarcoma. Proc. Natl. Acad. Sci. U.S.A., 80: 4861–4864. [DOI] [PMC free article] [PubMed] [Google Scholar]
  286. Sidhu, G. S. , Stahl, R. E. , El‐Sadr, W. , and Zolla‐Pazner, S. (1983) Ultrastructural markers of AIDS. Lancet, 1: 990–991. [DOI] [PubMed] [Google Scholar]
  287. Sidhu, G. S. , and Waisman, J. (1985) Panel discussion on tubuloreticular structures. Ultrastruct. Pathol., 8: 378–379. [Google Scholar]
  288. Siegal, F. P. , Lopez, C. , Hammer, G. S. , Brown, A. E. , Kornfeld, S. J. , Gold, J. , Hassett, J. , Hirschman, S. Z. , Cunningham‐Rundles, C. , Adelsberg, B. R. , Parham, D. M. , Siegal, M. , Cunningham‐Rundles, S. , and Armstrong, D. (1981) Severe acquired immunodeficiency in male homosexuals manifested by chronic perianal ulcerative herpes simplex lesions. N. Engl. J. Med., 305: 1439–1444. [DOI] [PubMed] [Google Scholar]
  289. Singer, D. R. , Fallon, T. J. , Schulenburg, W. E. , Williams, G. , and Cohen, J. (1985) Foscarnet for cytomegalovirus retinitis ‘letter’. Ann. Intern. Med., 103: 962. [DOI] [PubMed] [Google Scholar]
  290. Sinkovics, J. G. , Gyorkey, F. , and Thoma, G. W. (1969) A rapidly fatal case of systemic lupus erythematosus: Structures resembling viral nucleoprotein strands in the kidney and activities of lymphocytes in culture. Tex. Rep. Biol. Med., 27: 887–908. [PubMed] [Google Scholar]
  291. Snider, W. D. , Simpson, D. M. , Nielsen, S. , Gold, J. W. M. , Metroka, C. E. , and Posner, J. B. (1983) Neurological complications of acquired immune deficiency syndrome: Analysis of 50 patients. Ann. Neurol., 14: 403–418. [DOI] [PubMed] [Google Scholar]
  292. Sodroski, J. , Goh, W. C. , Rosen, C. , Dayton, A. , Terwilliger, E. , and Haseltine, W. (1986) A second post‐transcriptional trans‐activator gene required for HTLV‐III replication. Nature, 321: 412–417. [DOI] [PubMed] [Google Scholar]
  293. Sommerville, R. G. (1984) Cytomegalovirus—an update. Scott. Med. J. 29: 2–3. [DOI] [PubMed] [Google Scholar]
  294. Spector, D. H. , and Spector, S. A. (1984) The oncogenic potential of human cytomegalovirus. Prog. Med. Virol., 29: 45–89. [PubMed] [Google Scholar]
  295. Spector, S. A. , and Spector, D. H. (1985) The use of DNA probes in studies of human cytomegalovirus. Clin. Chem., 31: 1514–1520. [PubMed] [Google Scholar]
  296. Stagno, S. , Reynolds, D. W. , Pass, R. F. , and Alford, C. A. (1980) Breast milk and the risk of cytomegalovirus infection. N. Engl. J. Med., 302: 1073–1076. [DOI] [PubMed] [Google Scholar]
  297. Stoner, G. L. , Ryschkewitsch, C. F. , Walker, D. L. , and Webster, H. D. (1986) JC papovavirus large tumor (T)‐antigen expression in brain tissue of acquired immune deficiency syndrome (AIDS) and non‐AIDS patients with progressive multifocal leukoencephalopathy. Proc. Natl. Acad. Sci. U.S.A., 83: 2271–2275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  298. Stricker, R. B. , McHugh, T. M. , Moody, D. J. , Morrow, W. J. W. , Stites, D. P. , Shuman, M. A. , and Levy, J. A. (1987) An AIDS‐related cytotoxic autoantibody reacts with a specific antigen on stimulated CD4+ T cells. Nature, 327: 710–712. [DOI] [PubMed] [Google Scholar]
  299. Sullivan, J. L. , Brewster, F. E. , Brettler, D. B. , Forsberg, A. D. , Cheeseman, S. H. , Byron, K. S. , Baker, S. M. , Willitts, D. L. , Lew, R. A. , and Levine, P. H. (1986) Hemophiliac immunodeficiency: Influence of exposure to factor VIII concentrate, LAV/HTLV‐III, and herpesviruses. J. Pediatr., 108: 504–510. [DOI] [PubMed] [Google Scholar]
  300. Sumaya, C. V. , Boswell, R. N. , Ench, Y. , Kisner, D. L. , Hersh, E. M. , Reuben, J. M. , and Mansell, P. W. (1986) Enhanced serological and virological findings of Epstein‐Barr virus in patients with AIDS and AIDS‐related complex. J. Infect. Dis., 154: 864–870. [DOI] [PubMed] [Google Scholar]
  301. Sun, T. , and Teichberg, S. (1988) Protozoal infections in the acquired immunodeficiency syndrome. J. Electron Microsc. Tech., 8: 79–103. [DOI] [PubMed] [Google Scholar]
  302. Tajima, K. , Tominaga, S. , Kuroishi, T. , Shimizu, H. , and Suchi, T. (1979) Geographical features and epidemiological approach to endemic T‐cell leukemia/lymphoma in Japan. Jpn. J. Clin. Oncol. ‘Suppl.’, 9: 495–504. [Google Scholar]
  303. Takemoto, K. K. , Rabson, A. S. , Mullarkey, M. S. , Blaese, R. M. , Garon, C. F. , and Nelson, D. (1974) Isolation of a papovavirus from brain tumor and urine of a patient with Wiskott‐Aldrich syndrome. J.N.C.I., 53: 1205–1207. [DOI] [PubMed] [Google Scholar]
  304. Taylor, P. E. (1977) Adenoviruses: Diagnosis of infections In Kurstak E. and Kurstak C. (eds.): Comparative Diagnosis of Viral Disease. New York: Academic Press, Vol. 1, pp. 86–170. [Google Scholar]
  305. Thomas, H. C. , Scully, L. J. , Lever, A. M. L. , Yap, I. , and Pignatelli, M. (1987) A review of the efficacy of adenosine arabinoside and lymphoblastoid interferon in the Royal Free Hospital studies of hepatitis B virus carrier treatment: Identification of factors influencing response rates. Infection ‘Suppl.’, 15: 526–531. [DOI] [PubMed] [Google Scholar]
  306. Thune, P. , Andersson, T. , and Skjrten, F. (1983) Acquired immune deficiency syndrome (AIDS) manifesting as anogenital herpes zoster eruption: Demonstration of virus‐like particles in lymphocytes. Acta Derm. Venereol. (Stockh.), 63: 540–543. [PubMed] [Google Scholar]
  307. Towbin, H. , Stachelin, T. , and Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. U.S.A., 76: 4350–4359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  308. Tsuchie, H. , Katsumoto, T. , Hatori, N. , Kawatani, T. , Kurimura, T. , and Hinuma, Y. (1986) Budding process and fine structure of lymphadenopathy‐associated virus (LAV). Microbiol. Immunol., 30: 545–552. [DOI] [PubMed] [Google Scholar]
  309. Tuazon, C. U. , and Labriola, A. M. (1987) Management of infectious and immunological complications of acquired immunodeficiency syndrome (AIDS). Current and future prospects. Drugs, 33: 66–84. [DOI] [PubMed] [Google Scholar]
  310. Tucker, J. A. (1988) Malignancies in the acquired immunodeficiency syndrome. J. Electron Micros. Tech., 8: 137–158. [DOI] [PubMed] [Google Scholar]
  311. Tucker, T. , Dix, R. D. , Katzen, C. , Davis, R. L. , and Schmidley, J. W. (1985) Cytomegalovirus and herpes simplex virus ascending myelitis in a patient with acquired immune deficiency syndrome. Ann. Neurol., 18: 74–79. [DOI] [PubMed] [Google Scholar]
  312. Valle, S.‐L. , Saxinger, C. , Ranki, A. , Antonen, J. , Suni, J. , Lähdevirta, J. , and Krohn, K. (1985) Diversity of clinical spectrum of HTLV‐III infection. Lancet, 1: 301–304. [DOI] [PubMed] [Google Scholar]
  313. Vaucher, Y. E. , Ray, C. G. , Minnich, L. L. , Payne, C. M. , Beck, D. , and Lowe, P. (1982) Pleomorphic, enveloped, virus‐like particles associated with gastrointestinal illness in neonates. J. Infect. Dis., 145: 27–30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  314. Verani, P. , Mariani, G. , Mannucci, P. M. , DeRossi, G. , Nicoletti, L. , Titti, F. , Falcione, E. , Pasqualetti, D. , Ammassari, M. , Gringeri, A. , Mandelli, F. , and Rossi, G. B. (1986) Prevalence of HTLV‐III/LAV antibodies in Italian asymptomatic hemophiliacs given commercial concentrates of factors VIII and IX. J. Med. Virol., 19: 143–149. [DOI] [PubMed] [Google Scholar]
  315. Volberding, P. , Valeri, R. , Rothman, J. , and Gee, G. (1984) Alpha interferon therapy of Kaposi's sarcoma in AIDS. Ann. N.Y. Acad. Sci., 437: 439–446. [DOI] [PubMed] [Google Scholar]
  316. Volsky, D. J. , Wu, Y.‐T. , Sinangil, F. , and Goldsmith, J. C. (1986) HTLV‐III/LAV antibodies and virus in hemophilia patients in Nebraska: Survey and initiation of a prospective study. AIDS Res., 2: 51–61. [DOI] [PubMed] [Google Scholar]
  317. Wainberg, M. A. , and Mills, E. L. (1985) Mechanisms of virus‐induced immune suppression. Can. Med. Assoc. J., 132: 1261–1267. [PMC free article] [PubMed] [Google Scholar]
  318. Walker, D. L. (1978) Progressive multifocal leukoencephalopathy: An opportunistic viral infection of the central nervous system In Vinken P. J. and Bruyn G. W. (eds.): Infections of the Nervous System, Part II. Handbook of Clinical Neurology, Vol. 34 Amsterdam: North Holland, pp. 307–329. [Google Scholar]
  319. Walker, C. M. , Moody, D. J. , Stites, D. P. , and Levy, J. A. (1986) CD8+ lymphocytes can control HIV infection in vitro by suppressing viral replication. Science, 234: 1563–1566. [DOI] [PubMed] [Google Scholar]
  320. Ward, J. M. , O'Leary, T. J. , Baskin, G. B. , Benveniste, R. , Harris, C. A. , Nara, P. L. , and Rhodes, R. H. (1987) Immunohistochemical localization of human and simian immunodeficiency viral antigens in fixed tissue sections. Am. J. Pathol., 127: 199–205. [PMC free article] [PubMed] [Google Scholar]
  321. Warner, T. F. , Crass, B. , Gabel, C. , Maki, D. , Hafez, G. R. , and Golubjatnikov, R. (1986) Diagnosis of HTLV‐III infection by ultrastructural examination of germinal centers in lymph node—a case report. AIDS Res., 2: 43–50. [DOI] [PubMed] [Google Scholar]
  322. Watanabe, S. , Reddy, K. R. , Jeffers, L. , Dickinson, G. M. , O'Connell, M. , and Schiff, E. R. (1984) Electron microscopic evidence of non‐A, non‐B hepatitis markers and virus‐like particles in immunocompromised humans. Hepatology, 4: 628–632. [DOI] [PubMed] [Google Scholar]
  323. Weiner, L. P. , and Fleming, J. O. (1984) Viral infections of the nervous system. J. Neurosurg., 61: 207–224. [DOI] [PubMed] [Google Scholar]
  324. Weiss, S. H. , Goedert, J. J. , Sarngadharan, M. G. , Bodner, A. J. , The AIDS Seroepidemiology Collaborative Working Group , Gallo, R. C. , and Blattner, W. A. (1985) Screening test for HTLV‐III (AIDS agent) antibodies. J.A.M.A., 253: 221–225. [PubMed] [Google Scholar]
  325. Whang‐Peng, J. , Lee, E. C. , Sieverts, H. , and Magrath, I. T. (1984) Burkitt's lymphoma in AIDS: Cytogenetic study. Blood, 63: 818–822. [PubMed] [Google Scholar]
  326. White, D. O. , and Fenner, F. J. (1986) Medical Virology, 3rd edition New York: Academic Press. [Google Scholar]
  327. Whitley, R. J. , Alford, C. A. , Hirsch, M. S. , Schooley, R. T. , Luby, J. P. , Aoki, F. Y. , Hanley, D. , Nahmias, A. J. , Soong, S.‐J. , and NIAID Collaborative Antiviral Study Group (1987) Factors indicative of outcome in a comparative trial of acyclovir and vidarabine for biopsyproven herpes simplex encephalitis. Infection, 15 (Suppl. 1): S3–S8. [DOI] [PubMed] [Google Scholar]
  328. Wickenden, C. , Steele, A. , Malcolm, A. B. D. , and Coleman, D. V. (1985) Screening for wart virus infection in normal and abnormal cervices by DNA hybridization of cervical scrapes. Lancet, 1: 65–67. [DOI] [PubMed] [Google Scholar]
  329. Wiley, C. A. , Schrier, R. D. , Nelson, J. A. , Lampert, P. W. , and Oldstone, M. B. A. (1986) Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc. Natl. Acad. Sci. U.S.A., 83: 7089–7093. [DOI] [PMC free article] [PubMed] [Google Scholar]
  330. Winter, G. F. , Inglis, J. M. , and Cubie, H. A. (1987) Rapid diagnosis of herpes simplex virus infections in conventional and shell vial cultures using monoclonal antibodies. J. Virol. Methods, 15: 329–330. [DOI] [PubMed] [Google Scholar]
  331. Wittes, R. E. , and Killen, J. Y. (1984) Problems in the therapy of AIDS‐associated malignancies. Ann. N.Y. Acad. Sci., 437: 454–460. [DOI] [PubMed] [Google Scholar]
  332. Wood, M. J. , McKendrick, M. W. , and McGill, J. I. (1987) Oral acyclovir for acute herpes zoster infection in immune‐competent adults. Infection, 15 (Suppl. 1): S9–S11. [DOI] [PubMed] [Google Scholar]
  333. Yarchoan, R. , and Broder, S. (1986) Development of antiretroviral therapy for the acquired immunodeficiency syndrome and related disorders. N. Engl. J. Med., 316: 358–364. [DOI] [PubMed] [Google Scholar]
  334. Yoffe, B. , Noonan, C. A. , Melnick, J. L. , and Hollinger, F. B. (1986) Hepatitis B Virus DNA in mononuclear cells and analysis of cell subsets for the presence of replicative intermediates of viral DNA. J. Infect. Dis., 153: 471–477. [DOI] [PubMed] [Google Scholar]
  335. Yolken, R. H. , and Stopa, P. (1980) Comparison of seven enzyme immunoassay systems for measurement of cytomegalovirus. J. Clin. Microbiol., 11: 546–551. [DOI] [PMC free article] [PubMed] [Google Scholar]
  336. Youngs, R. P. , Stafford, N. D. , and Weber, J. (1986) AIDS: Otolaryngological presentation in the high‐risk male homosexual. Clin. Otolaryngol., 11: 137–144. [DOI] [PubMed] [Google Scholar]
  337. Zaloga, G. P. , Chernow, B. , and Eil, C. (1985) Hypercalcemia and disseminated cytomegalovirus infection in the acquired immunodeficiency syndrome. Ann. Intern. Med., 102: 331–333. [DOI] [PubMed] [Google Scholar]
  338. Ziegler, J. L. , Miner, R. C. , Rosenbaum, E. , Lennette, E. T. , Shillitoe, E. , Casavant, C. , Drew, W. L. , Mintz, L. , Gershow, J. , Greenspan, J. , Beckstead, J. , and Yamamoto, K. (1982) Outbreak of Burkitt's‐like lymphoma in homosexual men. Lancet, 2: 631–633. [DOI] [PubMed] [Google Scholar]
  339. Ziegler, J. L. , and Stites, D. P. (1986) Hypothesis: AIDS is an autoimmune disease directed at the immune system and triggered by a lymphotropic retrovirus. Clin. Immunol. Immunopathol., 41: 305–313. [DOI] [PubMed] [Google Scholar]
  340. Zucker‐Franklin, D. (1983) “Looking” for the cause of AIDS (Editorial) N. Engl. J. Med., 308: 837–838. [DOI] [PubMed] [Google Scholar]
  341. Zucker‐Franklin, D. (1985) Panel discussion on tubuloreticular structures Ultrastruct. Pathol., 8: 379. [Google Scholar]
  342. Zu Rhein, G. M. (1969) Association of papova‐virions with a human demyelinating disease (progressive multifocal leukoencephalopathy). Prog. Med. Virol., 11: 185–247. [PubMed] [Google Scholar]

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