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. 2007 Mar 12;42(4):393–396. doi: 10.1002/ppul.20595

Acute life threatening event (ALTE) in an infant with human coronavirus HCoV‐229E infection

Arne Simon 1,✉, Sebastian Völz 1, Katja Höfling 2, Alexandra Kehl 1, Ramona Tillman 2, Andreas Müller 1, Bernd Kupfer 2, Anna‐Maria Eis‐Hübinger 2, Michael J Lentze 1, Udo Bode 1, Oliver Schildgen 2
PMCID: PMC7167760  PMID: 17352399

Abstract

In this short report we discuss the temporal association between an acute life threatening event (ALTE) and a RT‐PCR confirmed coronavirus HCoV‐229E infection in a 4 months old otherwise healthy infant. More detailed microbiological investigations of affected children even without apparent signs of a respiratory tract infection may help to clarify the etiology in some patients and extend our understanding of the pathogenesis. PCR‐based techniques should be utilized to increase the sensitivity of detection for old and new respiratory viral pathogens in comparable cases. Pediatr Pulmonol. 2007; 42:393–396. © 2007 Wiley‐Liss, Inc.

Keywords: acute life threatening event (ALTE), coronavirus, infants

REFERENCES

  • 1. Tyrrell DA, Bynoe ML. Cultivation of a novel type of common‐cold virus in organ cultures. Br Med J 1965; 1: 1467–1470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2. McIntosh K. Coronaviruses in the limelight. J Infect Dis 2005; 191: 489–491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3. Drosten C, Gunther S, Preiser W, van der Werf S, Brodt HR, Becker S, Rabenau H, Panning M, Kolesnikova L, Fouchier RA, Berger A, Burguiere AM, Cinatl J, Eickmann M, Escriou N, Grywna K, Kramme S, Manuguerra JC, Muller S, Rickerts V, Sturmer M, Vieth S, Klenk HD, Osterhaus AD, Schmitz H, Doerr HW. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1967–1976. [DOI] [PubMed] [Google Scholar]
  • 4. van der Hoek L, Pyrc K, Jebbink MF, Vermeulen‐Oost W, Berkhout RJ, Wolthers KC, Wertheim‐van Dillen PM, Kaandorp J, Spaargaren J, Berkhout B. Identification of a new human coronavirus. Nat Med 2004; 10: 368–373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5. Fouchier RA, Rimmelzwaan GF, Kuiken T, Osterhaus AD. Newer respiratory virus infections: human metapneumovirus, avian influenza virus, and human coronaviruses. Curr Opin Infect Dis 2005; 18: 141–146. [DOI] [PubMed] [Google Scholar]
  • 6. Esper F, Shapiro ED, Weibel C, Ferguson D, Landry ML, Kahn JS. Association between a novel human coronavirus and Kawasaki disease. J Infect Dis 2005; 191: 499–502. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7. Esper F, Weibel C, Ferguson D, Landry ML, Kahn JS. Evidence of a novel human coronavirus that is associated with respiratory tract disease in infants and young children. J Infect Dis 2005; 191: 492–498. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8. Woo PC, Lau SK, Tsoi HW, Huang Y, Poon RW, Chu CM, Lee RA, Luk WK, Wong GK, Wong BH, Cheng VC, Tang BS, Wu AK, Yung RW, Chen H, Guan Y, Chan KH, Yuen KY. Clinical and molecular epidemiological features of coronavirus HKU1‐associated community‐acquired pneumonia. J Infect Dis 2005; 192: 1898–1907. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9. Lambert S, Mackay IM, Sloots TP, Nissen MD. Human coronavirus nomenclature. Pediatr Infect Dis J 2006; 25: 662. [DOI] [PubMed] [Google Scholar]
  • 10. Baker SC, Shimizu C, Shike H, Garcia F, van der Hoek L, Kuijper TW, Reed SL, Rowley AH, Shulman ST, Talbot HK, Williams JV, Burns JC. Human coronavirus‐NL63 infection is not associated with acute Kawasaki disease. Adv Exp Med Biol 2006; 581: 523–526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11. Chang LY, Chiang BL, Kao CL, Wu MH, Chen PJ, Berkhout B, Yang HC, Huang LM. Lack of association between infection with a novel human coronavirus (HCoV), HCoV‐NH, and Kawasaki disease in Taiwan. J Infect Dis 2006; 193: 283–286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12. Shimizu C, Shike H, Baker SC, Garcia F, van der Hoek L, Kuijpers TW, Reed SL, Rowley AH, Shulman ST, Talbot HK, Williams JV, Burns JC. Human coronavirus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease. J Infect Dis 2005; 192: 1767–1771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13. Ebihara T, Endo R, Ma X, Ishiguro N, Kikuta H. Lack of association between New Haven coronavirus and Kawasaki disease. J Infect Dis 2005; 351–352; author reply 353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14. Simon A, Khurana K, Wilkesmann A, Muller A, Engelhart S, Exner M, Schildgen O, Eis‐Hubinger AM, Groothuis JR, Bode U. Nosocomial respiratory syncytial virus infection: impact of prospective surveillance and targeted infection control. Int J Hyg Environ Health 2006; 209: 317–324. [DOI] [PubMed] [Google Scholar]
  • 15. Kurz H, Jakelj J, Aberle SW, Rohrbach DE, Dremsek PA, Sacher M. Long central apnea as the chief symptom of aseptic meningoencephalitis in a 6‐week‐old infant. Wien Klin Wochenschr 1999; 111: 294–297. [PubMed] [Google Scholar]
  • 16. Carbone T, Ostfeld BM, Gutter D, Hegyi T. Parental compliance with home cardiorespiratory monitoring. Arch Dis Child 2001; 84: 270–272. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17. Davies F, Gupta R. Apparent life threatening events in infants presenting to an emergency department. Emerg Med J 2002; 19: 11–16. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18. Wilkesmann A, Schildgen O, Eis‐Hubinger AM, Geikowski T, Glatzel T, Lentze MJ, Bode U, Simon A. Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory syncytial virus infections. Eur J Pediatr 2006; 165: 467–475. [DOI] [PubMed] [Google Scholar]
  • 19. Simon A, Groneck P, Kupfer B, Kaiser R, Plum G, Tillmann RL, Muller A, Schildgen O. Detection of bocavirus DNA in nasopharyngeal aspirates of a child with bronchiolitis. J Infect 2006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20. Moes E, Vijgen L, Keyaerts E, Zlateva K, Li S, Maes P, Pyrc K, Berkhout B, van der Hoek L, Van Ranst M. A novel pancoronavirus RT‐PCR assay: frequent detection of human coronavirus NL63 in children hospitalized with respiratory tract infections in Belgium. BMC Infect Dis 2005; 5: 6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21. Kupfer B, Simon A, Jonassen C, Viazov S, Ditt V, Tillmann RL, Müller A, Matz B, Schildgen O. Two cases of severe obstructive pneumonia associated with and HUK1‐like Coronavirus. Eur J Med Res 2007; 12: 1–5. [PubMed] [Google Scholar]
  • 22. Schildgen O, Geikowski T, Glatzel T, Simon A, Wilkesmann A, Roggendorf M, Viazov S, Matz B. New variant of the human metapneumovirus (HMPV) associated with an acute and severe exacerbation of asthma bronchiale. J Clin Virol 2004; 31: 283–288. [DOI] [PubMed] [Google Scholar]
  • 23. Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung‐Lindell A, Andersson B. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci USA 2005; 102: 12891–12896. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24. Heininger U, Kleemann WJ, Cherry JD. A controlled study of the relationship between Bordetella pertussis infections and sudden unexpected deaths among German infants. Pediatrics 2004; 114: e9–e15. [DOI] [PubMed] [Google Scholar]
  • 25. Templeton KE, Scheltinga SA, van der Zee A, Diederen BM, van Kruijssen AM, Goossens H, Kuijper E, Claas EC. Evaluation of real‐time PCR for detection of and discrimination between Bordetella pertussis, Bordetella parapertussis, and Bordetella holmesii for clinical diagnosis. J Clin Microbiol 2003; 41: 4121–4126. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26. Bastien N, Anderson K, Hart L, Van Caeseele P, Brandt K, Milley D, Hatchette T, Weiss EC, Li Y. Human coronavirus NL63 infection in Canada. J Infect Dis 2005; 191: 503–506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27. Sizun J, Soupre D, Giroux JD, Alix D, De P, Legrand MC, Demazure M, Chastel C. Nasal colonization with coronavirus and apnea of the premature newborn. Acta Paediatr 1993; 82: 238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 28. Sizun J, Soupre D, Legrand MC, Giroux JD, Rubio S, Cauvin JM, Chastel C, Alix D, de Parscau L. Neonatal nosocomial respiratory infection with coronavirus: a prospective study in a neonatal intensive care unit. Acta Paediatr 1995; 84: 617–620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29. Giudicelli J, Dubois F, Thouvenot D, Dutruge J, Bellon G. Coronavirus infection in infants: lower respiratory tract involvement, apnea and sudden death? Arch Pediatr 1995; 2: 185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 30. Gagneur A, Sizun J, Vallet S, Legr MC, Picard B, Talbot PJ. Coronavirus‐related nosocomial viral respiratory infections in a neonatal and paediatric intensive care unit: a prospective study. J Hosp Infect 2002; 51: 59–64. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 31. Brand DA, Altman RL, Purtill K, Edwards KS. Yield of diagnostic testing in infants who have had an apparent life‐threatening event. Pediatrics 2005; 115: 885–893. [DOI] [PubMed] [Google Scholar]
  • 32. St‐Jean JR, Jacomy H, Desforges M, Vabret A, Freymuth F, Talbot PJ. Human respiratory coronavirus O C43: genetic stability and neuroinvasion. J Virol 2004; 78: 8824–8834. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 33. Arbour N, Cote G, Lachance C, Tardieu M, Cashman NR, Talbot PJ. Acute and persistent infection of human neural cell lines by human coronavirus OC43. J Virol 1999; 73: 3338–3350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 34. Arbour N, Ekande S, Cote G, Lachance C, Chagnon F, Tardieu M, Cashman NR, Talbot PJ. Persistent infection of human oligodendrocytic and neuroglial cell lines by human coronavirus 229E. J Virol 1999; 73: 3326–3337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35. Fernandez‐Rodriguez A, Ballesteros S, de Ory F, Echevarria JE, Alvarez‐Lafuente R, Vallejo G, Gomez J. Virological analysis in the diagnosis of sudden children death: a medico‐legal approach. Forensic Sci Int 2006; 161: 8–14. [DOI] [PubMed] [Google Scholar]
  • 36. Gleeson M, Clancy RL, Cox AJ, Gulliver SA, Hall ST, Cooper DM. Mucosal immune responses to infections in infants with acute life threatening events classified as 'near‐miss' sudden infant death syndrome. FEMS Immunol Med Microbiol 2004; 42: 105–118. [DOI] [PubMed] [Google Scholar]
  • 37. Samuels M. Viruses and sudden infant death. Paediatr Respir Rev 2003; 4: 178–183. [DOI] [PubMed] [Google Scholar]
  • 38. Freymuth F, Vabret A, Cuvillon‐Nimal D, Simon S, Dina J, Legrand L, Gouarin S, Petitjean J, Eckart P, Brouard J. Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness. J Med Virol 2006; 78: 1498–1504. [DOI] [PMC free article] [PubMed] [Google Scholar]

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