Table 1.
Examples of proteases with additional non‐proteolytic functions
| Name (Synonyms) | Protease classification (Family) | Other function(s) | Organism | Predicted localisation | Found to be surface exposed |
|---|---|---|---|---|---|
| Aminopeptidase S* (SgAP) | Metalloaminopeptidase (M28) | Hydrolyses ester bonds | Streptomyces griseus 100 | Unknown | Unknown |
| C5a peptidase (scpA, scpB) | Serine endopeptidase (S8) | Adhesin | Streptococcus agalactiae 50 | Cell wall | Yes |
| Cpn60.2* (chaperone 60, HSP60/5) | Trypsin‐like endopeptidase | Chaperone | Mycobacterium leprae 90 | Cytoplasmic | Yes |
| DPPIV (dipeptidyl peptidase 4, Xaa‐Pro dipeptidyl peptidase, PepX, X‐prolyl dipeptidyl aminopeptidase) | Serine oligopeptidase (S9/S15) | Adhesin |
|
|
|
| Endopeptidase O (PepO, oligopeptidase 01, endopeptidase 2) | Metalloendopeptidase (M13) | Adhesin; accelerates plasminogen activation | Streptococcus pneumonia 65 | Cytoplasmic | Yes |
| FtsH* (high‐frequency lysogenisation by phage λ, hflB) | Metalloendopeptidase | Chaperone; AAA+ ATPase | Multiple organisms | Outer membrane | Yes |
| Gingipain (HRgpA/RgpB/Kgp, Arg/Lys‐gingipain) | Cysteine endopeptidase (C25) | Adhesin; Exopeptidase | Porphyromonas gingivalis 57, 58, 59 | Outer membrane and periplasmic space | Yes |
| Glutamyl aminopeptidase* (aminopeptidase A) | Metalloaminopeptidase (M42) | Adhesin; Accelerates plasminogen activation | Mycoplasma hyopneumoniae 66 | Cytoplasmic | Yes |
| HtrA* (high‐temperature requirement A, DegP, protease Do) | Serine endopeptidase (S1) | ChaperoneAdhesin | Multiple organismsBorrelia burgdorferi 86 | Cytoplasmic/periplasmicPeriplasmic | Yes |
| Leucine aminopeptidase* (cytosol aminopeptidase, LAP3, leucyl peptidase) | Metalloaminopeptidase (M17) | Adhesin; Accelerates plasminogen activation; DNA‐binding proteinDNA‐binding protein | M. hyopneumoniaeEscherichia coli 69 | CytoplasmicCytoplasmic | YesNo |
| Lon* ATP‐ dependent serine (proteinase, endopeptidase La, LonA, Lon type1) | Serine endopeptidase (S16) |
|
|
Cytoplasmic | No |
| NS3/4A (hepacivirin, Cpro‐2) | Serine endopeptidase (S29) | Helicase; nucleotide‐binding protein | Hepatitis C virus 125 | Viral capsid, host endoplasmic reticulum | Unknown |
| Papain‐like protease (PLP) | Cysteine endopeptidase (C16) | DUB; deISGylating; blocks cytokine induction | Coronaviridae and Arterivirdae viral families | Host cytoplasm | Unknown |
| PgtE (protein E) | Aspartic endopeptidase (A26) | Adhesin | Salmonella enterica senovar Typhimurium 42 | Outer membrane | Yes |
| Prolidase (Xaa‐Pro dipeptidase, imidodipeptidase, gamma peptidase, pepQ, proline dipeptidase | Metalloaminopeptidase (M24) | Hydrolyses ester bonds | Alteromonas haloplanktis 101 | Cytoplasmic | Unknown |
| Pla* (plasminogen activator) | Aspartic endopeptidase (A26) | Adhesin; coagulase | Yersinia pestis 8, 42, 44, 47 | Outer membrane | Yes |
| OmpT (protease 7, protease A) | Aspartic endopeptidase (A26) | Adhesin | Escherichia coli 42 | Outer membrane | Yes |
| SpeB (streptopain, erythrotoxin B, histase, In1β converatse, Streptococcus peptidase A) | Cysteine endopeptidase (C10) | Adhesin | Streptococcus pyogenes 39 | Extracellular | Yes |
| TAP (thioesterase I) | Serine endopeptidase | Thioesterase, arylesterase, esterase, lysophospholipase | Escherichia coli 102 | Unknown | Unknown |
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