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. 2012 Jan 16;23(3):339–348. doi: 10.1592/phco.23.3.339.32099

Pleconaril, a Novel Antipicornaviral Agent

Naomi R Florea 1, Dana Maglio 1, David P Nicolau 1,2,✉
PMCID: PMC7168037  PMID: 12627933

Abstract

Despite the availability of therapy for selected symptoms, no specific antiviral agents are available to treat or prevent infections due to the viruses of the Picornaviridae family—rhinoviruses and enteroviruses. Characterization of the three‐dimensional structure of picornaviruses in the 1980s allowed development of compounds targeted at the virus itself. Pleconaril is a novel, orally available, systemically acting molecule whose pharmacokinetics are characterized by a two‐compartment open model with first‐order absorption and with a safety profile similar to that of placebo. It shows promising results in treatment of picornaviral respiratory tract infections, meningitis, and other life‐threatening infections.

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