Figure 11.

Proposed model of the mechanisms involved in SLY-negative virulent S. suis strain 89-1591-induced IL-1β production by bmDCs. Bacterial recognition by bmDCs requires MyD88-dependent signaling and partial involvement of TLR2 via recognition of lipoproteins (LPs). Following internalization, bacterial DNA and RNA can also induce IL-1β production. S. suis recognition then leads to activation of the NF-κB, MEK and JNK pathways. Finally, activation of the NLRP3 and AIM2 inflammasomes, the latter by bacterial DNA following elevated internalization, is involved in caspase-1-dependent processing of IL-1β.