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. 2019 Dec 25;9(1):22. doi: 10.3390/pathogens9010022

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ICEs and IMEs carrying AMR genes in the 214 genomes of S. suis analyzed. Each panel of boxes represents the combination of AMR genes present on the corresponding ICE or IME indicated in the inner circle. ICEs are grouped by families (with an indication of the integration site for ICEs of the Tn5252 family) and IMEs by integration sites. Each outer circle corresponds to resistance genes against a family of antibiotics: teicoplanin, streptothricin, aminoglycosides, tetracyclines and macrolides (from outside to inside). Different colors are used for the boxes to distinguish the AMR genes: black for vanZ, green for sat4, yellow for ant(6)-Ia, salmon for ant(9)-Ia, orange for aph(3′)-IIIa, light blue for tet(40), blue for tet(O), darker blue for tet(M) (on Tn916) and tet(L) (on TnGBS2), light purple for tet(W) and deep purple for tet(O/W/32/O) and red for erm(B). The number of corresponding elements is indicated at the extremity of each panel of boxes. ICEs of the Tn5252 family are all counted even if the AMR genes are carried by IMEs integrated inside a conserved gene of the ICEs.