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. 2020 Apr 14;11(15):1373–1387. doi: 10.18632/oncotarget.27550

Figure 3. High dose (25 mg/kg) Rapatar treatment promotes development of reactive stroma and induces autophagy.

Figure 3

Markers of reactive stroma (αSMA, panel A) and autophagy (LC3B, panel B) were evaluated by immunostaining of LP sections from untreated Pten+/+ mice and psPten–/– mice treated with vehicle, 25 mg/kg Rapatar or 5 mg/kg Rapatar. In A, red staining indicates αSMA, blue is DAPI co-stain. White arrowheads indicate interruptions in αSMA staining and white asterisks show areas of strong staining for αSMA-positive activated fibroblasts. In B, brown staining indicates LC3B expression; red asterisks highlight areas of strong LC3B expression.