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. 2004 Sep 14;9:645–657. doi: 10.1016/S0168-7069(03)09040-2

VI, 3. Molecular biology and epidemiology of Aichi virus and other diarrhoeogenic enteroviruses

Teruo Yamashita 1, Kenji Sakae 1
PMCID: PMC7172506  PMID: 32336843

Publisher Summary

The virion of the Aichi virus contains a single-stranded RNA molecule as the genome. The homology of Aichi virus structural proteins (VP0, VP3, and VP1) with corresponding polypeptides of other picornaviruses varies between 19% and 32%. The epidemiology of the Aichi virus as a medically important pathogen has not been well defined. Stool samples from adult patients in six oyster-associated gastroenteritis outbreaks were examined for variation, based on their reactivity with a monoclonal antibody raised against the standard strain (A486/88) and on reverse transcription–polymerase chain reactions (RT-PCR) of three genomic regions. Antibody to the Aichi virus could be detected using a neutralization test and an enzyme-linked immunosorbent assay (ELISA). These methods were used for the identification of Aichi virus infection in paired serum samples. The chapter concludes with a discussion on other diarrheagenic enteroviruses.

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