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. 1998 Dec 12;4(8):1349–1353. doi: 10.1016/0968-0896(96)00123-X

Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus

Wolfgang Fitz a, Peter B Rosenthal b, Chi-Huey Wong a
PMCID: PMC7172942  PMID: 8879557

Abstract

2-α-Thiomethylmercuryl 9-acetamido-9-deoxy-sialoside was prepared and found to inhibit the 9-O-acetylsialic acid esterase from influenza C virus in a competitive manner with a Ki of 4.2±0.5 mM. The inhibitor is being used in the X-ray determination of the crystal structure of the esterase.

2-α-Thiomethylmercuryl 9-acetamido-9-deoxy-sialoside was prepared and found to be an inhibitor of the 9-O-acetylsialic acid esterase from influenza C virus with a Ki of 4.2 ± 0.5 mM. The inhibitor is being used in the X-ray determination of the crystal structure of the esterase.

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