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. 2004 Mar 25;66(6):1001–1007. doi: 10.1016/0002-9343(79)90457-1

Epidemic viral gastroenteritis

Mary Kolb Estes 1,1, David Yates Graham 1,∗,1
PMCID: PMC7173108  PMID: 222141

Abstract

Epidemic viral gastroenteritis is a significant world wide problem. In developed countries, gastroenteritis accounts for significant morbidity and loss of time from work; in the Third World it is the leading cause of mortality among infants and children. Recent technologic advances have been associated with an explosion of research activity. Two virus groups, the Norwalk-like agents and the rotaviruses, are currently accepted as causative agents of viral gastroenteritis in man. The problem of viral gastroenteritis is reviewed both from a current and a historic perspective.

Footnotes

This study was supported in part by a grant from Vick Divisions Research and Development, Mount Vernon, New York.

References

  • 1.Elliot K, Knight J. 2nd ed. Elsevier/Excerpta Medica; Amsterdam: 1976. Acute Diarrhea in Childhood; p. 341. (Ciba Foundation Symposium 42). [Google Scholar]
  • 2.Madeley CR, Cosgrove BP, Scott TM. 4th International Congress on Virology. Centre for Agricultural Publishing and Documentation; Wageningen, The Hague, The Netherlands: 1978. Observations on stool viruses in the community in Glasgow (abstract) p. 468. [Google Scholar]
  • 3.Koch R. Ueber bakteriologische forschung. Verhandl der X. International Medical Congress; Berlin; 1891. p. 35. [Google Scholar]
  • 4.Rivers TM. Viruses and Koch's postulates. J Bacteriol. 1937;33:1. doi: 10.1128/jb.33.1.1-12.1937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Huebner RJ. The virologist's dilemma. Ann NY Acad Sci. 1957;67:430. doi: 10.1111/j.1749-6632.1957.tb46066.x. [DOI] [PubMed] [Google Scholar]
  • 6.Light JS, Hodes HL. Studies on epidemic diarrhea of the new-born: isolation of a filtrable agent causing diarrhea in calves. Am J Pub Health. 1943;33:1451. doi: 10.2105/ajph.33.12.1451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Hodes HL. American Pediatric Society presidential address. Pediatr Res. 1976;10:201. doi: 10.1203/00006450-197603000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Reimann HA, Hodges JH, Price AH. Epidemic diarrhea, nausea and vomiting of unknown cause. JAMA. 1945;127:1. [Google Scholar]
  • 9.Gordon I, Ingraham HS, Korns RF. Transmission of epidemic gastroenteritis to human volunteers by oral administration of fecal filtrates. J Exp Med. 1947;86:409. doi: 10.1084/jem.86.5.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Gordon I, Meneely JK, Currie GD. Clinical laboratory studies in experimentally-induced epidemic nonbacterial gastroenteritis. J Lab Clin Med. 1953;41:133. [PubMed] [Google Scholar]
  • 11.Jordan WS, Gordon I, Dorrance WR. A study of illness in a group of Cleveland families. VII. Transmission of acute non-bacterial gastroenteritis to volunteers: evidence for two different etiologic agents. J Exp Med. 1953;98:461. doi: 10.1084/jem.98.5.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12.Fukumi H, Nakaya R, Hatta S. An indication as to identity between the infectious diarrhea in Japan and the afebrile infectious nonbacterial gastroenteritis by human volunteer experiments. Jpn J Med Sci Biol. 1957;10:1. doi: 10.7883/yoken1952.10.1. [DOI] [PubMed] [Google Scholar]
  • 13.Adler JL, Zickl R. Winter vomiting disease. J Infect Dis. 1969;119:668. doi: 10.1093/infdis/119.6.668. [DOI] [PubMed] [Google Scholar]
  • 14.Dolin R, Blacklow NR, DuPont H. Transmission of acute infectious nonbacterial gastroenteritis to volunteers by oral administration of stool filtrates. J Infect Dis. 1971;123:307. doi: 10.1093/infdis/123.3.307. [DOI] [PubMed] [Google Scholar]
  • 15.Dolin R, Blacklow NR, DuPont H. 2nd ed. Vol. 140. 1972. Biological properties of Norwalk agent of acute infectious nonbacterial gastroenteritis; p. 578. (Proc Soc Exp Biol Med). [DOI] [PubMed] [Google Scholar]
  • 16.Blacklow NR, Dolin R, Fedson DS. Acute infectious nonbacterial gastroenteritis: etiology and pathogenesis. Ann Intern Med. 1972;76:993. doi: 10.7326/0003-4819-76-6-993. [DOI] [PubMed] [Google Scholar]
  • 17.Kapikian AZ, Wyatt RG, Dolin R. Visualization by immune electron microscopy of a 27-nm particle associated with acute infectious nonbacterial gastroenteritis. J Virol. 1972;10:1075. doi: 10.1128/jvi.10.5.1075-1081.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Schreiber DS, Blacklow NR, Trier JS. The mucosal lesion of the proximal small intestine in acute infectious nonbacterial gastroenteritis. N Engl J Med. 1973;288:1318. doi: 10.1056/NEJM197306212882503. [DOI] [PubMed] [Google Scholar]
  • 19.Agus SG, Dolin R, Wyatt RG. Acute infectious nonbacterial gastroenteritis: intestinal histopathology. Histologic and enzymatic alterations during illness produced by the Norwalk agent in man. Ann Intern Med. 1973;79:18. doi: 10.7326/0003-4819-79-1-18. [DOI] [PubMed] [Google Scholar]
  • 20.Wyatt RG, Dolin R, Blacklow NR. Comparison of three agents of acute infectious nonbacterial gastroenteritis by cross-challenge in volunteers. J Infect Dis. 1974;129:709. doi: 10.1093/infdis/129.6.709. [DOI] [PubMed] [Google Scholar]
  • 21.Parrino TA, Schreiber DS, Trien JS. Clinical immunity in acute gastroenteritis caused by Norwalk agent. N Engl J Med. 1977;297:86. doi: 10.1056/NEJM197707142970204. [DOI] [PubMed] [Google Scholar]
  • 22.Wyatt RG, Greenberg HB, Dalgard DW. Experimental infection of chimpanzees with the Norwalk agent of epidemic viral gastroenteritis. J Med Virol. 1978;2:89. doi: 10.1002/jmv.1890020203. [DOI] [PubMed] [Google Scholar]
  • 23.Greenberg HB, Wyatt RG, Valdesuso J. Solid-phase microtiter radioimmunoassay for detection of the Norwalk strain of acute nonbacterial, epidemic gastroenteritis virus and its antibodies. J Med Virol. 1978;2:97. doi: 10.1002/jmv.1890020204. [DOI] [PubMed] [Google Scholar]
  • 24.Kapikian AZ, Greenberg HB, Cline WL. Prevalence of antibody to the Norwalk agent by a newly developed immune adherence hemagglutination assay. J Med Virol. 1978;2:281. doi: 10.1002/jmv.1890020402. [DOI] [PubMed] [Google Scholar]
  • 25.Suzuki H, Konno T, Ishida N. 4th International Congress on Virology. Center for Agricultural Publishing and Documentation; Wageningen, The Hague, The Netherlands: 1978. Parvovirus-like agent detected by EM in infantile diarrhea and its relationship to epidemic gastroenteritis in school children in Japan (Abstract) p. 471. [Google Scholar]
  • 26.Clarke SKR, Cook GT, Egglestone SI. A virus from epidemic vomiting disease. Br Med J. 1972;3:86. doi: 10.1136/bmj.3.5818.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Woode GN, Bridger JC. Isolation of small viruses resembling astroviruses and caliciviruses from acute enteritis of calves. J Med Microbiol. 1978;11:441. doi: 10.1099/00222615-11-4-441. [DOI] [PubMed] [Google Scholar]
  • 28.Bishop RF, Davidson GP, Holmes IH. Virus particles in epithelial cells of duodenal mucosa from children with acute non-bacterial gastroenteritis. Lancet. 1973;2:1281. doi: 10.1016/s0140-6736(73)92867-5. [DOI] [PubMed] [Google Scholar]
  • 29.Flewett TH, Bryden AS, Davies H. Virus particles in gastroenteritis. Lancet. 1973;2:1497. doi: 10.1016/s0140-6736(73)92760-8. [DOI] [PubMed] [Google Scholar]
  • 30.Flewett TH, Bryden AS, Davies H. Relation between viruses from acute gastroenteritis of children and newborn calves. Lancet. 1974;2:61. doi: 10.1016/s0140-6736(74)91631-6. [DOI] [PubMed] [Google Scholar]
  • 31.Davidson GP, Bishop RF, Townley RRW. Importance of a new virus in acute sporadic enteritis in children. Lancet. 1975;1:242. doi: 10.1016/s0140-6736(75)91140-x. [DOI] [PubMed] [Google Scholar]
  • 32.Tallett S, MacKenzie C, Middleton P. Clinical, laboratory and epidemiological features of a viral gastroenteritis in infants and children. Pediatrics. 1977;60:217. [PubMed] [Google Scholar]
  • 33.Kapikian AZ, Kim HW, Wyatt RG. Human reovirus-like agent as the major pathogen assoicated with “winter” gastroenteritis in hospitalized infants and young children. N Engl J Med. 1976;294:965. doi: 10.1056/NEJM197604292941801. [DOI] [PubMed] [Google Scholar]
  • 34.Elias MM. Distribution and titres of rotavirus antibodies in different age groups. J Hyg (Camb) 1977;79:365. doi: 10.1017/s0022172400053201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35.Ghose LH, Schnagl RD, Holmes IH. Comparison of an enzyme-lined immunoadsorbent assay for quantitation of rotavirus antibodies with complement fixation in an epidemiological surgery. J Clin Microbiol. 1978;8:268. doi: 10.1128/jcm.8.3.268-276.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 36.Woode GM. Epizootiology of bovine rotavirus infections. Vet Rec. 1978;103:44. doi: 10.1136/vr.103.3.44. [DOI] [PubMed] [Google Scholar]
  • 37.Yolken RH, Wyatt RG, Zissis G. Epidemiology of human rotavirus types 1 and 2 as studied by enzyme-linked immunosorbent assay. N Engl J Med. 1978;299:1156. doi: 10.1056/NEJM197811232992103. [DOI] [PubMed] [Google Scholar]
  • 38.Zissis G, Lambert JP. Different serotypes of human rotaviruses. Lancet. 1978;1:38. doi: 10.1016/s0140-6736(78)90380-x. [DOI] [PubMed] [Google Scholar]
  • 39.Thouless ME, Bryden AS, Flewett TH. Serotypes of human rotavirus. Lancet. 1978;1:39. doi: 10.1016/s0140-6736(78)90381-1. [DOI] [PubMed] [Google Scholar]
  • 40.Rodriguez WJ, Kim HW, Brandt CD. Sequential enteric illnesses associated with different rotavirus serotypes. Lancet. 1978;2:37. doi: 10.1016/s0140-6736(78)91339-9. [DOI] [PubMed] [Google Scholar]
  • 41.Flewett TH, Thouless ME, Pilfold JN. More serotypes of human rotavirus. Lancet. 1978;2:632. doi: 10.1016/s0140-6736(78)92854-4. [DOI] [PubMed] [Google Scholar]
  • 42.Chrystie IL, Totterdell BM, Banatvala JE. Asymptomatic endemic rotavirus infections in the newborn. Lancet. 1978;1:1176. doi: 10.1016/S0140-6736(78)90967-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 43.Murphy AM, Albrey MG, Crewe EB. Rotavirus infections of neonates. Lancet. 1977;2:1149. doi: 10.1016/S0140-6736(77)91538-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 44.Cukor G, Blackow N, Capozza F. Secretory IgA antibody to rotavirus in human milk 6–9 months postpartum. Lancet. 1978;1:631. doi: 10.1016/s0140-6736(78)92853-2. [DOI] [PubMed] [Google Scholar]
  • 45.Kalica AR, Sereno MM, Wyatt RG. Comparison of human and animal rotavirus strains by gel electrophoresis of viral RNA. Virology. 1978;87:247. doi: 10.1016/0042-6822(78)90130-7. [DOI] [PubMed] [Google Scholar]
  • 46.Woode GN, Bridger JC, Jones JM. Morphological and antigenic relationships between viruses (rotaviruses) from acute gastroenteritis of children, calves, piglets, mice and foals. Infect Immunol. 1976;14:804. doi: 10.1128/iai.14.3.804-810.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 47.Schoub BD, Lecatsas G, Prozesky OW. Antigenic relationship between human and simian rotaviruses. J Med Microbiol. 1977;10:1. doi: 10.1099/00222615-10-1-1. [DOI] [PubMed] [Google Scholar]
  • 48.Fauvel M, Spence L, Babiuk LA. Hemagglutination and hemagglutination-inhibition studies with a strain of Nebraska Calf Diarrhea Virus (bovine rotavirus) Intervirol. 1978;9:95. doi: 10.1159/000148927. [DOI] [PubMed] [Google Scholar]
  • 49.Rodger SM, Schnagl RD, Holmes IH. Further biochemical characterization, including the detection of surface glycoproteins, of human, calf, and simian rotaviruses. J Virol. 1977;24:91. doi: 10.1128/jvi.24.1.91-98.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 50.Elias MM. Separation and infectivity of two particle types of human rotavirus. J Gen Virol. 1977;37:191. doi: 10.1099/0022-1317-37-1-191. [DOI] [PubMed] [Google Scholar]
  • 51.Cohen J. Ribonucleic acid polymerase activity associated with purified calf rotavirus. J Gen Virol. 1977;36:395. doi: 10.1099/0022-1317-36-3-395. [DOI] [PubMed] [Google Scholar]
  • 52.Estes MK, Graham DY, Smith EM, Gerba CP: Rotavirus stability and inactivation. J Gen Virol (in press). [DOI] [PubMed]
  • 53.Wyatt RG, Gill VW, Sereno MM. Probable in-vitro cultivation of human reovirus-like agent of infantile diarroea. Lancet. 1976;1:98. doi: 10.1016/s0140-6736(76)90202-6. [DOI] [PubMed] [Google Scholar]
  • 54.Smith EM, Estes MK, Graham DY, et al.: A plaque assay for simian rotavirus SA11. J Gen Virol (in press). [DOI] [PubMed]
  • 55.Matsuno S, Inouye S, Kono R. Plaque assay of neonatal calf diarrhea virus and the neutralizing antibody in human sera. J Clin Microbiol. 1977;5:1. doi: 10.1128/jcm.5.1.1-4.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 56.Torres-Medina A, Wyatt RG, Mebus CA. Patterns of shedding of human reovirus-like agent in gnotobiotic newborn piglets with experimentally-induced diarrhea. Intervirology. 1976;7:250. doi: 10.1159/000149957. [DOI] [PubMed] [Google Scholar]
  • 57.Woode GN, Crouch CF. Naturally occurring and experimentally induced rotaviral infections of domestic and laboratory animals. J Am Vet Med Assoc. 1978;173:522. [PubMed] [Google Scholar]
  • 58.Mebus CA, Stair EL, Underdahl NR. Pathology of neonatal calf diarrhea induced by a reo-like virus. Vet Pathol. 1971;8:490. [Google Scholar]
  • 59.Moon HW. Mechanisms in the pathogenesis of diarrhea: a review. J Am Vet Med Assoc. 1978;172:443. [PubMed] [Google Scholar]
  • 60.Sack DA, Eusof A, Merson MH. Oral hydration in rotavirus diarrhoea: a double blind comparison of sucrose with glucose electrolyte solution. Lancet. 1978;1:280. doi: 10.1016/s0140-6736(78)91687-2. [DOI] [PubMed] [Google Scholar]
  • 61.Nalin DR, Mata L, Vargas W. Comparison of sucrose with glucose in oral therapy of infant diarrhoea. Lancet. 1978;1:277. doi: 10.1016/s0140-6736(78)91686-0. [DOI] [PubMed] [Google Scholar]
  • 62.Portnoy BL, DuPont HL, Pruitt D. Antidiarrheal agents in the treatment of acute diarrhea in children. JAMA. 1976;236:844. [PubMed] [Google Scholar]
  • 63.Estes MK, Graham DY. Rotavirus-cell interactions. Proceedings of the 2nd International Symposium on Neonatal Diarrhea; Saskatoon, Saskatchewan, Canada; October 1978. (in press) [Google Scholar]

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