Fig. 1.
Lethal infection of PRV in C3H mice. (A-D) Four-week old, male C3H mice were infected with PRV strain MB at 2 × 104, 2 × 105, and 2 × 106 PFU via the intranasal route (A, B) or 2 × 107 PFU via the oral route (C, D). Body weight (A, C) and survival rate (B, D) were recorded daily. (E-G) C3H mice were infected with PRV strain MB via the (E) intranasal route (2 × 105 PFU /head) or (F) oral route (2.0 × 107 PFU / head). At day 2, 4, and 6 post infection, animals were sacrificed and infectious viral titers in internal organs were examined. (G) Induction of blood cytokines (IP-10) through the time course of PRV infection. Data are expressed as the means ± SD, n = 6–10. NT: not tested.