FIG 4.

CD147^–/– BMDM and mice are resistant to infection with E. chaffeensis. BMDM from WT or CD147^–/– mice were incubated with E. chaffeensis for 48 h (A). WT and CD147^–/– mice (five mice per group) were infected with E. chaffeensis for 4 days (B). Quantitative PCR was performed for the E. chaffeensis (Ech) 16S rRNA gene and mouse GAPDH to compare infection levels in BMDM and blood specimens. Results represent the means plus SD from at least three independent experiments and were compared by Student’s t test. *, P < 0.05.