Scheme 3.
Synthesis of 2-oxoesters. (a) (i) Cs2CO3, THF, H2O (pH 9); (ii) DMF, reflux, 24–72 h; (b) Dess Martin, dry CH2Cl2, r.t., 3 h; (c) 50% TFA, dry CH2Cl2, r.t., 2 h.
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