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. 2020 Apr 22;7(8):2070044. doi: 10.1002/advs.202070044

Nanoparticle Vaccines: In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity (Adv. Sci. 8/2020)

Ziyang Xu 1,2, Megan C Wise 3, Neethu Chokkalingam 1, Susanne Walker 1, Edgar Tello‐Ruiz 1, Sarah T C Elliott 1, Alfredo Perales‐Puchalt 1, Peng Xiao 1, Xizhou Zhu 1, Ruth A Pumroy 2, Paul D Fisher 3, Katherine Schultheis 3, Eric Schade 3, Sergey Menis 4,5,6, Stacy Guzman 1, Hanne Andersen 7, Kate E Broderick 3, Laurent M Humeau 3, Kar Muthumani 1, Vera Moiseenkova‐Bell 2, William R Schief 4,5,6,8, David B Weiner 1, Daniel W Kulp 1,9
PMCID: PMC7175322

Abstract

In article number https://doi.org/10.1002/advs.201902802, David B. Weiner, Daniel W. Kulp, and co‐workers demonstrate that synthetic DNA delivery and adaptive electroporation can launch de novo assembly of different nanoparticle vaccines in the hosts to elicit significantly improved responses while reducing required doses. Next‐generation designer vaccines can now be rapidly evaluated in vivo to facilitate clinical translation for the betterment of human and animal health.

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Keywords: DNA vaccines, in vivo self‐assembly, infectious diseases, nanoparticle vaccines, protein engineering


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