Table 4a.
Cut off values, area under curve of ROC, and Youden Index of CTX, OC, and ON in discriminating healthy from total periodontitis based on BL, BOP, and PPD.
| Cut-off (ng/mL) | Se (%) | Sp (%) | AUC | 95% CI | P | YI | ||
|---|---|---|---|---|---|---|---|---|
|
Healthy vs. Total Periodontitis
(BOP: 10% BL: 15%; PPD: 4 mm) |
CTX | 18.3 | 91.67 | 70.00 | 0.873 | 0.787–0.934 | 0.001 | 0.783 |
| 20.19 | 91.67 | 86.67 | ||||||
| 22.14 | 88.33 | 86.67 | ||||||
| OC | 9.21 | 100 | 56.67 | 0.871 | 0.783–0.932 | 0.001 | 0.667 | |
| 15.25 | 90.00 | 76.67 | ||||||
| 25.99 | 41.67 | 100.0 | ||||||
| ON | 55.0 | 93.33 | 53.33 | 0.833 | 0.739–0.903 | 0.001 | 0.667 | |
| 68.2 | 80.00 | 86.67 | ||||||
| 98.2 | 45.0 | 90.0 | ||||||
Se: sensitivity; Sp: specificity; ROC: receiver operator characteristic; AUC: area under curve; 95% CI: 95% confidence interval (CI); YI: Youden Index = Se + Sp − 1; PPD: probing pocket depth; BOP: bleeding on probing; BL: bone loss; CTX: deoxypyridinoline-containing degradation fragment of the C-terminal telopeptide region of type I collagen; OC: osteocalcin; ON: osteonectin.