Table 5.
Effect of analogues 11a, 11b, 12a, 12b and 13c on cleaved caspase-3 levels, and expression levels of Bcl-2 and Bax in MCF-7 cancer cells treated with the compounds at their IC50 concentrations.
| Compounds | Caspase-3 Activity % | Bcl-2 (ng/50 mg Protein) | p53 (Pg/50 mg Protein) | Bax (pg/50 mg Protein) |
|---|---|---|---|---|
| Control (MCF-7) | 10.2 ± 2.84 | 25.13 ± 3.45 | 4.18 ± 0.58 | 39.56 ± 4.56 |
| 11a | 16.67 ± 0.67 | 12.3 ± 2.26 | 14.45 ± 0.82 | 122.34 ± 3.45 |
| 11b | 16.19 ± 0.79 | 16.18 ± 0.78 | 5.85 ± 0.75 | 109.35 ± 4.05 |
| 12a | 14.18 ± 0.74 | 13.09 ± 2.27 | 13.31 ± 1.08 | 113.09 ± 1.98 |
| 12b | 47.25 ± 1.89 | 12.87 ± 1.84 | 29.58 ± 2.53 | 167.07 ± 4.83 |
| 13c | 39.07 ± 4.97 | 44.5 ± 4.56 | 7.34 ± 1.5 | 88.34 ± 3.79 |
Data = mean ± SD.