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. 2020 Apr 8;109(5):653. doi: 10.1007/s00392-020-01620-1

Correction to: Rationale and design of two randomized sham‑controlled of catheter‑based renal denervation in subjects with uncontrolled hypertension in the absence (SPYRAL HTN‑OFF MED Pivotal) and presence (SPYRAL HTN‑ON MED Expansion) of antihypertensive medications: a novel approach using Bayesian design

Michael Böhm 1,, Raymond R Townsend 2, Kazuomi Kario 3, David Kandzari 4, Felix Mahfoud 1, Michael A Weber 5, Roland E Schmieder 6, Konstantinos Tsioufis 7, Graeme L Hickey 8, Martin Fahy 8, Vanessa DeBruin 8, Sandeep Brar 8, Stuart Pocock 9
PMCID: PMC7182632  PMID: 32270345

Correction to: Clinical Research in Cardiology (2020) 109:289–302 https://doi.org/10.1007/s00392-020-01595-z

The original version of this article unfortunately contained a mistake. The sentence within the section “Bayesian design and prespecified interim analyses” should read:

Due to a Bayesian power prior approach being used, a non-standard parameterization for the ANCOVA model is used to allow for informative prior distributions to be placed separately on the RDN and control arm effects:

yi=μtIit+μcIic+xiβ+εi;εiN0,σ2,

where yi denotes the change from baseline in BP at follow-up, subscripts i denote the ith subject with evaluable data, Iit=1 if subject i is randomized to renal denervation, or =0 if randomized to sham control, and β is the regression coefficient for the adjustment in mean-centered baseline BP, xi.

The original article has been corrected.


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