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Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2020 Apr 9:ciaa408. doi: 10.1093/cid/ciaa408

Early virus clearance and delayed antibody response in a case of COVID-19 with a history of co-infection with HIV-1 and HCV

Juanjuan Zhao 1,#, Xuejiao Liao 1,#, Haiyan Wang 1, Lanlan Wei 1, Mingzhao Xing 2, Lei Liu 1,2,#, Zheng Zhang 1,2,#,
PMCID: PMC7184426  PMID: 32270178

Abstract

The effect of host immune status on SARS-CoV-2 infection remains unknown. Here, we report the first case of COVID-19 with HIV-1 and HCV co-infection, who showed a persistently negative SARS-CoV-2 RNA test, but delayed antibody response in the plasma. This case highlights the influence of HIV-1-induced immune dysfunction on the early SARS-CoV-2 clearance.

Keywords: SARS-CoV-2, COVID-19, HIV-1, HCV, Antibody


Articles from Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America are provided here courtesy of Oxford University Press

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