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. 2020 Jan 26;71(4):1262–1278. doi: 10.1002/hep.30917

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© 2019 The Authors. Hepatology published by Wiley Periodicals, Inc. on behalf of American Association for the Study of Liver Diseases

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Hepatocyte‐specific MANF deficiency promotes mice HCC growth. (A) Liver morphology and H&E staining. WT and MANF‐KO mice were treated with DEN (30 mg/kg) by intraperitoneal injection at postnatal day 15, and livers were harvested at 8 months after DEN injection. a: cancer foci, b: para‐cancer. (B‐E) Effects of MANF knockout on body weight and tumor growth. Mice were sacrificed at 8 months after DEN treatment. n = 6; *P < 0.05; **P < 0.01, compared to WT. (B) The liver/body weight ratio. (C) The number of tumors (diameter ≥1 mm) on the surface of livers. (D) The length (left), width (middle), and volume (right) of maximal tumor on the surface of livers. (E) The average length (left), width (middle), and volume (right) of tumors on the surface of livers. (F) MANF expression in liver tissues of WT mice treated with DEN. a: cancer foci, b: para‐cancer. Abbreviation: H&E, hematoxylin and eosin.