Figure 7.

PK in whole blood for ¹²⁵I-M616 (top left), ¹¹¹In-M616 (bottom left), in C57BL/6 mice dosed 0.3 mg/kg IV alone, or as a cassette plus 9.7 mg/kg (10 mg/kg total M616) unlabeled M616. Note the lack of effect of a large excess of unlabeled M616 on the PK of the 0.3 mg/kg tracer dose until >12 h, consistent with a lack of significant IL-36 R target in the central (blood) compartment. Additionally, consistent PK profiles across distinct labeling strategies suggest insignificant uptake and catabolism within the blood compartment. (Top/bottom right) TCA precipitation analysis confirms that both conjugates remain fully intact in blood during the course of the study in all dose groups.