Table 4. Univariate and multivariate COX regression analysis based on tumour-specific survival.

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI of HR	P-value	HR	95% CI of HR	P-value
Age (≤79 vs. >79)	0.912	[0.277–3.004]	0.88	/	/	/
T (Ta–T1/T2–T4)	17.897	[6.251–51.244]	<0.001	6.569	[1.919–22.486]	0.003
N (N0/N1–N3)	16.434	[7.557–35.738]	<0.001	3.817	[1.335–10.914]	0.012
M (M0/M1)	13.118	[5.283–2.596]	<0.001	5.013	[1.183–21.242]	0.029
Grade (low/high)	5.985	[2.757–12.992]	<0.001	1.002	[0.384–2.616]	0.996
CDCA8 (low/high)	3.981	[1.781–8.9]	<0.001	2.548	[1.062–6.114]	0.036
Progression (no/yes)	6.414	[3.184–12.922]	<0.001	5.639	[2.236–14.226]	<0.001
Gender (male/female)	0.477	[0.22–1.032]	0.06	/	/	/