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. 2020 May 4;437:130–131. doi: 10.1016/j.neuroscience.2020.04.044

Fig. 1.

Fig. 1

Summarization of three possible ways by which SARS-CoV-2 enters the brain and causes neuroinfection. We propose three possible patterns about the entry of SARS-CoV-2 into brain, namely, via the olfactory nerves in the nasal cavity (①), interaction with angiotensin-converting enzyme-2 (ACE-2) in the brain (②) and a cytokine storm-induced blood brain barrier disruption (③).