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. 2020 May 4;15(5):e0231944. doi: 10.1371/journal.pone.0231944

Fig 1. Thrombin receptor, protease-activated receptor 1 (PAR1), is expressed in human myometrium.

Fig 1

(A-C) Immunofluorescence of PAR1 (green) in myometrium from a pregnant woman (A), non-pregnant woman (B), and fetal membrane (C). Nuclei were stained with DAPI (blue). Am, amnion, Cho, chorion, Deci, decidua. (D-G) Localization of hemorrhage, thrombin, and PAR1 in placental abruption at 25 weeks of gestation (D and E), and 33 weeks gestation (F and G) resulting in disseminated intravascular coagulopathy and uterine bleeding requiring hysterectomy for hemostasis. (D and F) Hematoxylin and eosin staining of the myometrium adjacent to the placenta. Note that hemorrhage infiltrated the myometrium. Bars, 50 μm. (E and G) Immunofluorescence of PAR1 (green), thrombin (red), and DAPI (blue) at the same location of (A). Bars, 50 μm.