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. 2020 May 4;15(5):e0231944. doi: 10.1371/journal.pone.0231944

Fig 6. Effect of thrombin on contraction-associated proteins in myometrial cells.

Fig 6

(A) IL1B, GJA1, OXTR, PTGER1, PTGER3, and PTGFR mRNA gene expression in thrombin (2 U/mL)-treated myometrial cells at 24 h. n = 3 in each group. (B) Gene expressions of myometrial cells with treatment of 0.1 ng/mL of IL-1β at 24 h. (C) mRNA expressions of PTGER and PTGFR with treatment of thrombin or IL-1β, pretreated with indomethacin. (D) Gene expressions of myometrial cells with treatment of 0.1 μM of PGE2 (D) or 0.1 μM of PGF2α (E) at 24 h. n = 3. *, p < 0.05, and **, p < 0.01. (F) Scheme of regulation of contraction associated proteins by thrombin. The experiments were repeated three times.