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. 2020 May 6;7(9):2000890. doi: 10.1002/advs.202000890

Circ‐MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self‐Renewal of Hepatocellular Cancer Stem Cells

Liang Chen, Ruijiao Kong, Cong Wu, Shuo Wang, Zixin Liu, Shupeng Liu, Shuiping Li, Tian Chen, Chuanbin Mao, Shanrong Liu
PMCID: PMC7201249  PMID: 32382492

Adv. Sci. 2019, 7, 1900949

In the originally published article, incorrect gel sections were presented in Figure 1C and Figure 2C, Supporting Information. Also, the wrong images and caption were presented in Figure 1C, Supporting Information. The corrected panels of the figures are presented below.

Figure 1.

Figure 1

Circ‐MALAT1 is highly expressed in Hepatocellular CSCs. C) Divergent primers amplified circR‐MALAT1, circ‐CDYL, and circ‐TCONS_I2 in cDNA but not genomic DNA (gDNA) or RNA (No RT). Convergent Primers could amplify linear RNA and circRNA in cDNA and parental gene in gDNA.

Figure S1.

Figure S1

(Related to Figure 1.) C) The protein levels of both CSC marker (OCT4) and HCC marker (AFP) were measured in spheres by immunofluorescence. Scale bar, 20 μm. Columns, mean from three independent experiments; bars, SD. ** P< 0.01.

Figure S2.

Figure S2

(Related to Figure 1.) CircRNAs are expressed differentially in HCC CSCs. C) Divergent primers amplified 6 candidate circRNAs in cDNA but not genomic DNA (gDNA) and RNA (No RT).

In Figure 1, panel 1C (Hep3B cell line: circ‐MALAT1 and circ‐TCONS_I2; and Huh7 cell line: circ‐MALAT1) is corrected. In Figure 2C, Supporting Information, panel 2C (Hep3B cell line: circ‐HIPK3 and circ‐SPARC; and Huh7 cell line: circ‐FKBP10, circ‐HIPK3 and circ‐RPPH1) is corrected. The entirety of Figure 1C, Supporting Information is corrected. These corrections do not change the conclusions of this article. The authors apologize for any misunderstandings that these technical errors in figure preparation may have caused.


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