Table 1.
Characteristics of patients with non-small cell lung cancer according to CD200 and CD200R1 expression.
| Tumoral CD200 expression* |
Tumoral CD200R1 expression* | Stromal CD200R1 expression* |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total |
Low |
High |
Low |
High |
Low |
High |
||||
| Characteristics | N = 632 | N = 359 (55.1) | N = 272 (41.8) | P – value | N = 261 (41.4) | N = 370 (58.6) | P – value | N = 463 (73.5) | N = 167 (26.5) | P – value |
| Age, years | ||||||||||
| Median | 68 | 68 | 68 | 0.211 | 68 | 68 | 0.184 | 68 | 68 | 0.186 |
| Range | [23.0, 88.0] | [23.0, 88.0] | [33.0, 75.0] | [23.0, 85.0] | [33.0, 88.0] | [23.0, 88.0] | [34.0, 88.0] | |||
| Sex | ||||||||||
| Male | 434 (68.7) | 284 (79.1) | 149 (54.8) | < 0.001 | 148 (56.7) | 285 (77.0) | < 0.001 | 290 (62.6) | 142 (85.0) | < 0.001 |
| Female | 198 (31.3) | 75 (20.9) | 123 (45.2) | 113 (43.3) | 85 (23.0) | 173 (37.4) | 25 (15.0) | |||
| Smoking status | ||||||||||
| Ever | 434 (68.7) | 287 (79.9) | 146 (53.7) | < 0.001 | 149 (57.1) | 284 (76.8) | < 0.001 | 284 (61.3) | 148 (88.6) | < 0.001 |
| Never | 185 (29.3) | 62 (17.3) | 123 (45.2) | 109 (41.8) | 76 (20.5) | 168 (36.3) | 17 (10.2) | |||
| Unknown | 13 (2.0) | 10 (2.8) | 3 (1.1) | 3 (1.1) | 10 (2.7) | 11 (2.4) | 2 (1.2) | |||
| Histology | ||||||||||
| Adenocarcinoma | 415 (65.7) | 175 (48.8) | 239 (87.9) | < 0.001 | 195 (74.7) | 219 (59.2) | < 0.001 | 345 (74.5) | 69 (41.3) | < 0.001 |
| Squamous cell carcinoma | 173 (27.3) | 147 (40.9) | 25 (9.2) | 46 (17.6) | 127 (34.3) | 92 (19.9) | 80 (47.9) | |||
| Others | 44 (7.0) | 37 (10.3) | 8 (2.9) | 20 (7.7) | 24 (6.5) | 26 (5.6) | 18 (10.8) | |||
| Tumor status | ||||||||||
| pT1 | 259 (41.0) | 107 (29.8) | 152 (55.9) | < 0.001 | 112 (42.9) | 147 (39.7) | 0.788 | 208 (44.9) | 50 (29.9) | 0.002 |
| pT2 | 274 (43.3) | 179 (49.9) | 94 (34.6) | 108 (41.4) | 165 (44.6) | 191 (41.3) | 82 (49.1) | |||
| pT3 | 62 (9.8) | 51 (14.2) | 11 (4.0) | 27 (10.3) | 35 (9.5) | 37 (8.0) | 25 (15.0) | |||
| pT4 | 37 (5.9) | 22 (6.1) | 15 (5.5) | 14 (5.4) | 23 (6.2) | 27 (5.8) | 10 (6.0) | |||
| Node metastasis | ||||||||||
| pN0 | 470 (74.4) | 247 (68.8) | 222 (81.6) | 0.002 | 207 (79.3) | 262 (70.8) | 0.124 | 359 (77.5) | 109 (65.3) | 0.006 |
| pN1 | 71 (11.2) | 52 (14.5) | 19 (7.0) | 24 (9.2) | 47 (12.7) | 44 (9.5) | 27 (16.2) | |||
| pN2-3 | 91 (14.4) | 60 (16.7) | 31 (11.4) | 30 (11.5) | 61 (16.5) | 60 (13.0) | 31 (18.5) | |||
| Stage | ||||||||||
| Ι | 400 (63.3) | 195 (54.4) | 204 (75.0) | < 0.001 | 175 (67.0) | 224 (60.5) | 0.230 | 306 (66.1) | 92 (55.1) | 0.032 |
| ΙΙ | 109 (17.2) | 82 (22.8) | 27 (9.9) | 42 (16.1) | 67 (18.1) | 76 (16.4) | 33 (19.8) | |||
| ΙΙΙ | 123 (19.5) | 82 (22.8) | 41 (15.1) | 44 (16.9) | 79 (21.4) | 81 (17.5) | 42 (25.1) | |||
| Post-operative adjuvant chemotherapy | ||||||||||
| No | 375 (59.3) | 210 (58.5) | 163 (59.9) | 0.744 | 161 (61.7) | 213 (57.6) | 0.324 | 269 (58.1) | 104 (62.3) | 0.360 |
| Yes | 257 (40.7) | 149 (41.5) | 109 (40.1) | 100 (38.3) | 157 (42.4) | 194 (41.9) | 63 (37.7) | |||
| EGFR mutation with IHC | ||||||||||
| Wild | 503 (79.6) | 321 (89.4) | 181 (66.5) | < 0.001 | 201 (77.0) | 301 (81.4) | 0.193 | 349 (75.4) | 152 (91.0) | < 0.001 |
| Mutant | 129 (20.4) | 38 (10.6) | 91 (33.5) | 60 (23.0) | 69 (18.6) | 114 (24.6) | 15 (9.0) | |||
| ALK expression | ||||||||||
| Negative | 622 (98.4) | 353 (98.3) | 268 (98.5) | 1.000 | 260 (99.6) | 361 (97.6) | 0.052 | 453 (97.8) | 167 (100.0) | 0.070 |
| Positive | 10 (1.6) | 6 (1.7) | 4 (1.5) | 1 (0.4) | 9 (2.4) | 10 (2.2) | 0 (0) | |||
| TTF-1 expression | ||||||||||
| Negative | 247 (39.1) | 207 (57.8) | 38 (14.0) | < 0.001 | 94 (36.0) | 153 (41.5) | 0.185 | 138 (29.8) | 108 (65.0) | < 0.001 |
| Positive | 384 (60.9) | 151 (42.2) | 234 (86.0) | 167 (64.0) | 216 (58.5) | 325 (70.2) | 58 (35.0) | |||
Variables are presented as N (%). Abbreviations: IHC (immunohistochemistry).
* Protein expressions with IHC was not evaluated on several cases due to insufficient material; N = 1 for tumoral CD200, N = 1 for tumoral CD200R1, and N = 2 for stromal CD200R1.