Fig. 7.

Alpha-mangostin protective effects against HG-induced death in HUVECs. Incubation of HUVECs with high glucose (60 mM) for 6 days significantly reduced viability vs. control group (normal glucose), alpha-mangostin and metformin significantly increased viability vs. control. The cellular viability was measured by MTT assay. Values represent the mean ± SD of four independent experiments. Statistical significance was set at ***P < 0.001 vs. control and ^###p < 0.001, ^####p < 0.0001 vs. HG group. HG = high glucose, alpha-MG = alpha-mangostin